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| 1 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 2 | Dubin-Johnson syndrome coinciding with colon cancer and atherosclerosis显示文摘Hyperbilirubinemia has been presumed to prevent the process of atherogenesis and cancerogenesis mainly by decreasing oxidative stress.Dubin-Johnson syndrome is a rare,autosomal recessive,inherited disorder characterized by biphasic,predominantly conjugatedhyperbilirubinemia with no progression to end-stage liver disease.The molecular basis in Dubin-Johnson syndrome is absence or deficiency of human canalicular multispecific organic anion transporter MRP2/cMOAT caused by homozygous or compound heterozygous mutation(s) in ABCC2 located on chromosome 10q24.Clinical onset of the syndrome is most often seen in the late teens or early adulthood.In this report,we describe a case of previously unrecognized Dubin-Johnson syndrome caused by two novel pathogenic mutations (c.2360_2366delCCCTGTC and c.3258+1G>A),coinciding with cholestatic liver disease in an 82-year-old male patient.The patient,suffering from advanced atherosclerosis with serious involvement of coronary arteries,developed colorectal cancer with nodal metastases.The subsequent findings do not support the protective role of Dubin-Johnson type hyperbilirubinemia. | Eva Sticova Milan Elleder Helena Hulkova Ondrej Luksan Martin Sauer Irena Wunschova-Moudra Jan Novotny Milan Jirsa | 2013 | World Journal of Gastroenterology2013，19，6： | 4 |
| 3 | Mixed antagonist response and sepsis severity-dependent dysbalance of pro- and anti-inflammatory responses at the onset of postoperative sepsis显示文摘 | Alexander R. Novotny Daniel Reim Volker Assfalg Felicitas Altmayr Helmut M. Friess Klaus Emmanuel Bernhard Holzmann | 2011 | Immunobiology2011，，6： | 3 |
| 4 | Techno-economic comparison of three technologies for precombustion CO2 capture from a lignite-fired IGCC显示文摘This paper compares the techno-economic performances of three technologies for CO2 capture from a lignite-based IGCC power plant located in the Czech Republic:(1)Physical absorption with a Rectisol-based process;(2)Polymeric CO2-selective membrane-based capture;(3)Low-temperature capture.The evaluations show that the IGCC plant with CO2 capture leads to costs of electricity between 91 and 120€·MWh−1,depending on the capture technology employed,compared to 65€·MWh−1 for the power plant without capture.This results in CO2 avoidance costs ranging from 42 to 84€·tCO2,avoided−1,mainly linked to the losses in net power output.From both energy and cost points of view,the low-temperature and Rectisol based CO2 capture processes are the most efficient capture technologies.Furthermore,partial CO2 capture appears as a good mean to ensure early implementation due to the limited increase in CO2 avoidance cost when considering partial capture.To go beyond the two specific CO2-selective membranes considered,a cost/membrane property map for CO2-selective membranes was developed.This map emphasise the need to develop high performance membrane to compete with solvent technology.Finally,the cost of the whole CCS chain was estimated at 54€·tCO2,avoided−1 once pipeline transport and storage are taken into consideration. | Simon Roussanaly Monika Vitvarova Rahul Anantharaman David Berstad Brede Hagen Jana Jakobsen Vaclav Novotny Geir Skaugen | 2020 | Frontiers of Chemical Science and Engineering2020，14，3： | 3 |
| 5 | Single balloon enteroscopy for endoscopic retrograde cholangiography in patients with Roux-en-Y hepaticojejuno anastomosis显示文摘AIM:To evaluate single balloon enteroscopy in diagnostic and therapeutic endoscopic retrograde cholangiography(ERC)in patients with Roux-en-Y hepaticojejunoanastomosis(HJA).METHODS:The study took place from January 2009to December 2011 and we retrospectively assessed 15patients with Roux-en-Y HJA who had signs of biliary obstruction.In total,23 ERC procedures were performed in these patients and a single balloon videoen-teroscope(Olympus SIF Q 180)was used in all of the cases.A transparent overtube was drawn over the videoenteroscope and it freely moved on the working part of the enteroscope.Its distal end was equipped with a silicone balloon that was inflated by air from an external pump at a pressure of≤5.4 kPa.The technical limitations or rather the parameters of the single balloon enteroscope(working length-200 cm,diameter of the working channel-2.8 mm,absence of Albarran bridge)showed the need for special endoscopic instrumentation.RESULTS:Cannulation success was reached in diagnostic ERC in 12 of 15 patients.ERC findings were normal in 1 of 12 patients.ERC in the remaining 11 patients showed some pathological changes.One of these(cystic bile duct dilation)was subsequently resolved surgically.Endoscopic treatment was initialized in the remaining 10 patients(5 with HJA stenosis,2 with choledocholithiasis,and 3 with both).This treatment was successful in 9 of 10 patients.The endoscopic therapeutic procedures included:balloon dilatation of HJA stenosis-11 times(7 patients);choledocholitiasis extraction-five times(5 patients);biliary plastic stent placement-six times(4 patients);and removal of biliary stents placed by us-six times(4 patients).The mean time of performing a single ERC was 72 min.The longest procedure took 110 min and the shortest took34 min.This shows that it is necessary to allow for more time in individual procedures.Furthermore,these procedures require the presence of an anesthesiologist.We did not observe any complications in these 15 patients.CONCLUSION:This method is more demanding than standard endoscopic retrograde cholangiopancreatography due to altered postsurgical anatomy.However,it is effective,safe,and widens the possibilities of resolving biliary pathology. | Bohuslav Kianika Jan Lata Ivo Novotny Petr Dítě Jirí Vaníek | 2013 | World Journal of Gastroenterology2013，19，44： | 2 |
| 6 | Indolicidin,a novel bactericidal tridecapeptide amide from neutrophils显示文摘 | Selsted M E Novotny M J Morris W L | 1992 | J Biol Chem1992，267，： | 2 |
| 7 | Repeat Gamma Knife Radiosurgery for Trigeminal Neuralgia显示文摘 | Kyung-Jae Park Douglas Kondziolka Oren Berkowitz Hideyuki Kano Josef Novotny Ajay Niranjan John C. Flickinger L. Dade Lunsford | 2012 | Neurosurgery2012，，2： | 2 |
| 8 | Grain Size Distribution of Soils within the Cordillera Blanca, Peru: An Indicator of Basic Mechanical Properties for Slope Stability Evaluation显示文摘This paper presents results of a study on the mechanical properties of sandy and gravely soils within the Cordillera Blanca, Peru. The soils were divided into groups according to their origin(glacial, fluvial, or debris flow). The grain size distribution of forty three soil samples was used to classify the soils according to the scheme of the Unified Soil Classification System(USCS). These distributions have then been used to estimate shear strength and hydraulic properties of the soils. There are clear differences between the soils which reflect their divergent origins. The glacial soils normally fit within one of two distinctive groups according to the proportion of fines(Group A, 7%-21.5%; Group B, 21%-65%). The estimation of shear strength at constant volume friction angle and peak shear strength of the glacial sediments with low content of fines was made using published data relating to the measured shear strength characteristics of soils with similar origins and grain size distributions. The estimated values were supported by measurements of the angle of repose taken from fourteen samples from two moraines and by shear tests on samples from one locality. The results of the grain size distribution werealso used to estimate the average hydraulic conductivity using the empirical Hazen formula which results were verified by field infiltration tests at two localities. | Jan NOVOTNY Jan KLIME | 2014 | Journal of Mountain Science2014，11，3： | 2 |
| 9 | Process design for hydroforming of lightweight metal sheets at elevated temperatures显示文摘 | S. Novotny M. Geiger | 2003 | Journal of Materials Processing Tech2003，，1： | 2 |
| 10 | A rapid and automated low resolution NMR method to analyze oil quality in intact oilseeds显示文摘 | Rosilene Aparecida Prestes Luiz Alberto Colnago Lucimara Aparecida Forato Lucinéia Vizzotto Etelvino Henrique Novotny Emanuel Carrilho | 2007 | Analytica Chimica Acta2007，，2： | 2 |
| 11 | Bevacizumab plus irinotecan,fluorouracil,and leucovorin for metastatic colorectal cancer显示文摘 | Hurwitz H Fehrenbacher L Novotny W | | 0，，： | 2 |
| 12 | Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer 显示文摘 | Hurwitz H Fehrenbacher L Novotny W | 2004 | N Engl J Med2004，350，23： | 1 |
| 13 | A self-performing chromatographic immunoassay for the qualitative determination of human chorionic gonadotrophic(HCG)in urine and serum显示文摘 | Novotny M Sampedro S | 1990 | Clin Chem1990，36，2： | 1 |
| 14 | Leksell gamma knife treatment of uveal melanoma显示文摘 | SIMONOVA G NOVOTNY J LISCAK R | 2002 | J Neurosurg2002，97，： | 1 |
| 15 | Bevacizumab plus irinotecan,fluorouracil,and leucovorin for metastatic colorectal cancer显示文摘 | Hurwitz H Fehrenbacher L Novotny W | 2004 | N Engl J Med2004，350，23： | 1 |
| 16 | Gas chromatography-mass spectrometric and nuclear magnetic resonance determination of polynuclear aromatic hydrocarbons in airborne particulates 显示文摘 | LEE M L NOVOTNY M BARTLE K D | 1976 | Anal Chem1976，48，： | 1 |
| 17 | Bevacizunurb plus irinotecan fluomuracii and leucovorin for metastatic colorectal cancer显示文摘 | Humitz H Fehrenbacher L Novotny W | 2004 | N Engl J Med2004，350，23： | 1 |
| 18 | Willingness to pay for flood and ecological risk reduction in an urban watershed显示文摘 | Clark D E Novotny V Griffin R | 2001 | Water Science & Technology2001，45，9： | 1 |
| 19 | Leksell Gamma Knife lesioning of the rat hippocampus: the relationship between radiation dose and functional and structural damage显示文摘 | Liscak R Vladyka V Novotny J Jr | 2002 | J Neurosurg2002，97，5： | 1 |
| 20 | Equation monodimensionnelle dumgaz vizqueux et calorifere avec des conditions initialmoins restrictive显示文摘 | FUJITA-YASHIMA H PADULA M NOVOTNY A | 1993 | Ricerche Mat1993，42，： | 1 |
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