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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Mental retardation and relation to seizure and tuber burden in tuberous sclerosls eotnplex 显示文摘 | Zaroff CM Barr WB Carlson C LaJoie J Madhavan D Miles DK | 2006 | Seizure2006，15，7： | 1 |
| 3 | Effects of three harvest schedules on forage yield, quality, and persistence of six alfalfa cultivars显示文摘 | Carlson I T Obierika I D C | 1981 | Agricultural Reviews and Manuals1981，19，： | 1 |
| 4 | Perturbative QCD calculations of heavy meson exlusive decays显示文摘 | Milana J | 1993 | Phys lett1993，301，： | 1 |
| 5 | Rattlesnake venom shock in the rat:development of a method显示文摘 | Richard W Carlson Richard C | 1975 | Am J Physiol1975，229，6： | 1 |
| 6 | Disparity mapping applied to sonography of the breast 显示文摘 | Steinberg B D Sullivan D C Carlson D L | 1998 | Radiology1998，207，2： | 1 |
| 7 | Effect of river landscape on the sediment concentrations of antibiotics and corresponding antibiotic resistance genes(ARG)显示文摘 | PEI R KIM S C CARLSON K H PRUDEN A | 2006 | Water Res2006，40，12： | 1 |
| 8 | A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression 显示文摘 | Zarate C A Singh J B Carlson P J | 2006 | Arch Gen Psychiatry2006，63，： | 1 |
| 9 | A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome显示文摘 | Carlson H Ota S Campbell C E | 2001 | Hum Mol Genet2001，10，21： | 1 |
| 10 | Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading 显示文摘 | CARLSON C J BOOTH F W GORDON S E | 1999 | Am J Physiol1999，277，： | 1 |
| 11 | Starlike and prestarlike hypergeometric functions显示文摘 | Carlson B C Sharer D B | 1984 | SIAM J Math Anal1984，15，： | 1 |
| 12 | Growth-promoting effects of fermented soybeans for broilers 显示文摘 | CHAH C C CARLSON C W SEMENIUK G | 1977 | Poultry Science1977，54，： | 1 |
| 13 | Stem cell therapy restores transparency to defective murine corneas显示文摘 | Du Y Carlson E C Funderburgh M L | | 0，，07： | 1 |
| 14 | Determining data informa- tion literacy needs: A study of students and research faculty 显示文摘 | Carlson J Fosmire M Miller C C | 2011 | por- tal: Libraries and the Academy2011，11，2： | 1 |
| 15 | Growth-Promoting Effects of Fermented Soybeans for Broilers显示文摘 | Chah C C Carlson C W Semeniuk G | 1977 | Poultry Science1977，54，： | 1 |
| 16 | Oceanic bacterial production显示文摘 | Ducklow H W Carlson C A | 1992 | Advances in Microbial Ecology1992，，12： | 1 |
| 17 | Characterization of vitellogenin from white sturgeon Acipenser transmontanus 显示文摘 | BidweU C A Carlson D M | 1995 | Mol Evol1995，41，1： | 1 |
| 18 | Completing the Viability Demonstra- tion of Direct-Drive IFE Target Engagement and Assessing Scalability to a Full-Scale Power Plant 显示文摘 | Carlson L C | 2010 | Transactionson Plasma Science2010，38，3： | 1 |
| 19 | Frequent and Variable Cytotoxic-T-Lymphocyte Escape-Associated Fitness Costs in the Human Immunodeficiency Virus Type 1Subtype B Gag Proteins显示文摘 | Boutwell C L Carlson J M Lin T H Seese A Power K A Peng J Tang Y Brumme Z L Heckerman D Schneidewind A Allen TM | 2013 | J Virol2013，87，7： | 1 |
| 20 | Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon显示文摘 | Geurts A M Wilber A Carlson C M | 2006 | BMC Biotechnol2006，6，： | 1 |
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