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| 1 | Derivation of hypermethylated pluripotent embryonic stem cells with high potency显示文摘天真的 hypomethylated 胚胎的 pluripotent 干细胞(转换字符) 离胚囊的 preimplantation epiblast 发展地最靠近,与潜力到贡献所有胚胎的纸巾和 germline,除了在妄想的胚胎的胚胎外的纸巾。由对比,类似于 postimplantation epiblast 的 epiblast 干细胞(EpiSCs ) 是相对更多的 methylated 和表演为 chimerism 的一个有限潜力。第一次,这里,我们在 pluripotent 房间以外发展地揭示先进 pluripotent 干细胞(ASC ) ,它是在内部房间团中,但是与更高的力量比 EpiSCs。因此,单个 ASC 在怪物很高效地作出贡献到胎儿, germline,蛋黄囊和胎盘的迷宫。因为他们是,发展地,更多进展了, ASC 不贡献 trophoblast。ASC 在与 Activin A 和基本成纤维细胞生长因素补充的化学上定义的媒介在二个步骤从胚囊被导出,在包含 ActA, BMP4, CHIR99021 和白血病的 ABCL 媒介由 culturing 列在后面禁止的因素。尤其是, ASC 与天真的 pluripotency 基因,以及 mesodermal 的表示展出不同 transcriptome 体的基因;Eomes,时代, Tdgf1, Evx1, hand1, Wnt5a 和不同重复元素。到 ASC 的确定的转换字符的变换也是可完成的。重要地, ASC 作为与 hypomethylated 相比展出稳定的 hypermethylated epigenome 和主要未经触动的印记胚囊和天真的转换字符的内部房间质量。ASC 的性质建议他们以在 pluripotency 的天真、告知的状态之间的一个中间的细胞的状态代表房间。 | Siqin Bao Walfred WC Tang Baojiang Wu Shinseog Kim Jingyun Li Lin Li Toshihiro Kobayashi Caroline Lee Yanglin Chen Mengyi Wei Shudong Li Sabine Dietmann Fuchou Tang Xihe Li | 2018 | Cell Research2018，28，1： | 4 |
| 2 | Effects of smoking and solid-fuel use on COPD, lung cancer, and tuberculosis in China: a time-based, multiple risk factor, modelling study显示文摘 | Hsien-Ho Lin Megan Murray Ted Cohen Caroline Colijn Majid Ezzati | 2008 | 2008 (9648)2008，，9648： | 2 |
| 3 | NASH and insulin resistance: Insulin hypersecretion and specific association with the insulin resistance syndrome显示文摘 | Shivakumar Chitturi Shehan Abeygunasekera Geoffrey C. Farrell Jane Holmes-Walker Jason M. Hui Caroline Fung Rooshdiya Karim Rita Lin Dev Samarasinghe Christopher Liddle Martin Weltman Jacob George | 2002 | Hepatology2002，，2： | 1 |
| 4 | FcγRIIIa polymorphisms and cetuximab induced cytotoxicity in squamous cell carcinoma of the head and neck显示文摘 | Rodney J. Taylor Siaw-Lin Chan Aaron Wood Caroline J. Voskens Jeffrey S. Wolf Wei Lin Andrei Chapoval Dan H. Schulze Guoliang Tian Scott E. Strome | 2009 | Cancer Immunology, Immunotherapy2009，，7： | 1 |
| 5 | Effects of smoking and solid-fuel use on COPD, lung cancer, and tuberculosis in China: a time-based, multiple risk factor, modelling study显示文摘 | Hsien-Ho Lin Megan Murray Ted Cohen Caroline Colijn Majid Ezzati | 2008 | The Lancet . 2008 (9648)2008，，： | 1 |
| 6 | Integrated analysis of the performance of pile-supported bridges under scoured conditions显示文摘 | Cheng Lin Caroline Bennett Jie Han Robert L. Parsons | 2011 | Engineering Structures2011，，： | 1 |
| 7 | 为关联感设计:面向老年人的交互服务设计探索显示文摘在过去的几十年里,我们经历了人类预期寿命的大幅提高,与此同时,人口老龄化也成为了一个世界性的现象,在安全、移动、卫生保健和社会福利等各个领域都带来了严峻的挑战。随着老龄过程中身心健康水平的下降和社交圈的缩小,老年人往往挣扎于维系良好生活质量和社会关系的过程中。与此同时,互联网和相关技术的快速发展却也为研究人员和设计师们带来了新的机遇以改善老年人与他人交流沟通的体验、减少老年群体被社会孤立的风险。随着数字生活和现实生活的逐渐融合,通过实体交互与嵌入现实环境的相关技术来帮助老年人等相对远离数字生活的群体重返大众网络的研究探索展现出新的潜力。在本文中,我们主要介绍三个案例研究,分别着眼于老年人的三个典型情境,旨在提高他们与他人的社会联系。基于这些设计实践中的经验,我们探讨了以支持、改善老年人社交生活为目的的交互设计在老年公寓环境中的潜力和未来可能的方向。 | Xu Lin Kai Kang Cun Li Bart Hengeveld Caroline Hummels Matthias Raterberg Jun Hu 蒋天韵(翻译) 陈祥洁(翻译) | 2019 | 创意与设计2019，，3： | 1 |
| 8 | Differential seeding and propagating efficiency ofα-synuclein strains generated in different conditions显示文摘Background:Accumulation of alpha-synuclein(α-syn)is a main pathological hallmark of Parkinson’s and related diseases,which are collectively known as synucleinopathies.Growing evidence has supported that the same protein can induce remarkably distinct pathological progresses and disease phenotypes,suggesting the existence of strain difference amongα-syn fibrils.Previous studies have shown thatα-syn pathology can propagate from the peripheral nervous system(PNS)to the central nervous system(CNS)in a“prion-like”manner.However,the difference of the propagation potency from the periphery to CNS among differentα-syn strains remains unknown and the effect of different generation processes of these strains on the potency of seeding and propagation remains to be revealed in more detail.Methods:Three strains of preformedα-syn fibrils(PFFs)were generated in different buffer conditions which varied in pH and ionic concentrations.Theα-syn PFFs were intramuscularly(IM)injected into a novel bacterial artificial chromosome(BAC)transgenic mouse line that expresses wild-type humanα-syn,and the efficiency of seeding and propagation of these PFFs from the PNS to the CNS was evaluated.Results:The three strains ofα-syn PFFs triggered distinct propagation patterns.The fibrils generated in mildly acidic buffer led to the most severeα-syn pathology,degeneration of motor neurons and microgliosis in the spinal cord.Conclusions:The differentα-syn conformers generated in different conditions exhibited strain-specific pathology and propagation patterns from the periphery to the CNS,which further supports the view thatα-syn strains may be responsible for the heterogeneity of pathological features and disease progresses among synucleinopathies. | Di Liu Jian-Jun Guo Ji-Hui Su Alexander Svanbergsson Lin Yuan Caroline Haikal Wen Li Gunnar Gouras Jia-Yi Li | 2021 | Translational Neurodegeneration2021，10，2： | 0 |
| 9 | 分校打赏,美国大学少数派高端生存报告显示文摘一说起分校,在国内总是被误解成民办高校或独立学院,要不就是“野鸡”大学招摇撞骗的幌子。事实是,国外绝大多数分校办学实力超群,发展势头强劲。学长有二十多位朋友在美国高校的分校里学习和工作,现将他们打赏给我的文章收集整合,与学弟学妹们分享那些“少数派”分校里的故事。Warm-up·预热A.中国大学“分校区”中国的“分校区”大多是指与“本校”除地理区位不同外其余方面皆保持一致的“本校分部”,在各方面都直接受“本部”领导。如西南大学合并后的原西南师范大学校区和原西南农业大学校区,四川大学合并后的原川大老校区、新校区、原华西医科大学校区,以及哈尔滨工业大学和哈尔滨工业大学(威海)、哈尔滨工业大学(深圳)等。 | 邓景鸿 芥末君 Luc Qiao Caroline Lang Karen Fong Juicily Lin | 2017 | 大学(高考金刊)2017，0，10： | 0 |
| 10 | Collagen membrane functionalized with magnesium oxide via room-temperature atomic layer deposition promotes osteopromotive and antimicrobial properties显示文摘Artificial bone grafting materials such as collagen are gaining interest due to the ease of production and implantation.However,collagen must be supplemented with additional coating materials for improved osteointegration.Here,we report room-temperature atomic layer deposition(ALD)of MgO,a novel method to coat collagen membranes with MgO.Characterization techniques such as X-ray photoelectron spectroscopy,Raman spectroscopy,and electron beam dispersion mapping confirm the chemical nature of the film.Scanning electron and atomic force microscopies show the surface topography and morphology of the collagen fibers were not altered during the ALD of MgO.Slow release of magnesium ions promotes bone growth,and we show the deposited MgO film leaches trace amounts of Mg when incubated in phosphate-buffered saline at 37◦C.The coated collagen membrane had a superhydrophilic surface immediately after the deposition of MgO.The film was not toxic to human cells and demonstrated antibacterial properties against bacterial biofilms.Furthermore,in vivo studies performed on calvaria rats showed MgO-coated membranes(200 and 500 ALD)elicit a higher inflammatory response,leading to an increase in angiogenesis and a greater bone formation,mainly for Col-MgO500,compared to uncoated collagen.Based on the characterization of the MgO film and in vitro and in vivo data,the MgO-coated collagen membranes are excellent candidates for guided bone regeneration. | Soumya Saha Raphael Cavalcante Costa Mirela Caroline Silva Joao Matheus Fonseca-Santos Lin Chen Abhijit H.Phakatkar Harshdeep Bhatia Leonardo P.Faverani Valentim A.R.Barao Tolou Shokuhfar Cortino Sukotjo Christos Takoudis | 2023 | Bioactive Materials2023，，12： | 0 |
| 11 | Factors That Influence Tax Avoidance in Indonesia Stock Exchange显示文摘 | Yuniarwati I Cenik Ardana Sofia Prima Dewi Caroline Lin | 2017 | Chinese Business Review2017，16，10： | 0 |
| 12 | 二十一世纪国家艺术博物馆显示文摘建筑设计概念以及城市策略:可能性领域的划分通过维持与原军队营房的索引关系,博物馆的设计提出了建筑与其所在城市文脉的问题。这绝不是对地貌混合拼凑的尝试,而是为了应对平衡场地周边的强势街区脉络,所提出的对弱城市肌理的延续。 | Zaha Hadid Patrik Schumacher Anja Simons Paolo Matteuzzi Fabio Ceci Mario Mattia Maurizio Meossi Paolo Zilli Luca Peralta Maria Velceva Matteo Grimal Ana M.Cajiao Barbara Pfenningstorff Dillon Lin Kenneth Bostock Raza Zahid Lars Teichmann Adriano De Gioannis Amin Taha Caroline Voet Gianluca Ruggeri Luca Segarelli | 2016 | 建筑创作2016，0，6： | 0 |
| 13 | Are University Rankings Statistically Significant?A Comparison among Chinese Universities and with the USA显示文摘Purpose:Building on Leydesdorff,Bornmann,and Mingers(2019),we elaborate the differences between Tsinghua and Zhejiang University as an empirical example.We address the question of whether differences are statistically significant in the rankings of Chinese universities.We propose methods for measuring statistical significance among different universities within or among countries.Design/methodology/approach:Based on z-testing and overlapping confidence intervals,and using data about 205 Chinese universities included in the Leiden Rankings 2020,we argue that three main groups of Chinese research universities can be distinguished(low,middle,and high).Findings:When the sample of 205 Chinese universities is merged with the 197 US universities included in Leiden Rankings 2020,the results similarly indicate three main groups:low,middle,and high.Using this data(Leiden Rankings and Web of Science),the z-scores of the Chinese universities are significantly below those of the US universities albeit with some overlap.Research limitations:We show empirically that differences in ranking may be due to changes in the data,the models,or the modeling effects on the data.The scientometric groupings are not always stable when we use different methods.Practical implications:Differences among universities can be tested for their statistical significance.The statistics relativize the values of decimals in the rankings.One can operate with a scheme of low/middle/high in policy debates and leave the more fine-grained rankings of individual universities to operational management and local settings.Originality/value:In the discussion about the rankings of universities,the question of whether differences are statistically significant,has,in our opinion,insufficiently been addressed in research evaluations. | Loet Leydesdorff Caroline SWagner Lin Zhang | 2021 | Journal of Data and Information Science2021，6，2： | 0 |
| 14 | Molecular signature of soil organic matter under different land uses in the Lake Chaohu Basin显示文摘The concentration and molecular composition of soil organic matter(SOM)are important factors in mitigation against climate change as well as providing other ecosystem services.Our quantitative understanding of how land use influences SOM molecular composition and associated turnover dynamics is limited,which underscores the need for high-throughput analytical approaches and molecular marker signatures to clarify this etiology.Combining a high-throughput untargeted mass spectrometry screening and molecular markers,we show that forest,farmland and urban land uses result in distinct molecular signatures of SOM in the Lake Chaohu Basin.Molecular markers indicate that forest SOM has abundant carbon contents from vegetation and condensed organic carbon,leading to high soil organic carbon(SOC)concentration.Farmland SOM has moderate carbon contents from vegetation,and limited content of condensed organic carbon,with SOC significantly lower than that of forest soils.Urban SOM has high abundance of condensed organic carbon markers due to anthropogenic activities but relatively low in markers from vegetation.Consistently,urban soils have the highest black carbon/SOC ratio among these land uses.Overall,our results suggested that the molecular signature of SOM varies significantly with land use in the Lake Chaohu Basin,influencing carbon dynamics.Our strategy of molecular fingerprinting and marker discovery is expected to enlighten further research on SOM molecular signatures and cycling dynamics. | Han Gao Huixin Li Chen Lin Pedro J.J.Alvarez Caroline A.Masiello Dongqiang Zhu Ao Kong Xiaolei Qu | 2022 | Eco-Environment & Health2022，1，4： | 0 |
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