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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Sustaining four wheel drive tourism in desert Australia: Exploring the evi- deuce from a demand perspective显示文摘 | Carson D Taylor A | 2008 | Tbe Rangeland Journal2008，30，1： | 1 |
| 3 | Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma 显示文摘 | Hedvat M Jain A Carson D A st al | 2004 | Cancer Cell2004，5，6： | 1 |
| 4 | Efficacy of powered intracapsular tonsillectomy and adenoidectomy 显示文摘 | Tunkel D E Hotchkiss K S Carson K A | 2008 | Laryngoscope2008，118，7： | 1 |
| 5 | Correlation between self-ignition of a dust layer on a hot surface and in baskets in an oven显示文摘 | Janes A Carson D Accorsi A | 2008 | Journal of Hazardous Materials2008，159，23： | 1 |
| 6 | 显示文摘 | CARSON R T VIGNALI D A | 1999 | Journal of Immunological Methods1999，227，： | 1 |
| 7 | En- hancing Community-Based Disaster Preparedness with Information Technology 显示文摘 | TROY D A CARSON A VANDERBEEK J | 2008 | Disastesr2008，，1： | 1 |
| 8 | Quantification of plaque neovascularization using contrast ultrasound: a histologic validation 显示文摘 | Moguillansky D Leng X Carson A | 2011 | Eur Heart J2011，32，5： | 1 |
| 9 | MIKE 3 versus HARTMANN apparatus:Comparison of measured minimum ignition energy (MIE)显示文摘 | Janes A Chaineaux J Carson D | 2008 | Journal of Hazardous Materials2008，152，1： | 1 |
| 10 | KCNQ currents and their contribution to resting membrane potential and the excitability of inter-stitial cells of Cajal from the guinea pig bladder显示文摘 | Anderson U A Carson C McCloskey K D | 2009 | J Urol2009，182，1： | 1 |
| 11 | Standardization of a broth microdilution susceptibility testing method to determine minimum inhibitory concentrations of aquatic bacteria 显示文摘 | MILLER R A WALKER R D CARSON J | 2005 | Diseases of Aquatic Organisms2005，64，： | 1 |
| 12 | Clearing a Path Through the Management Fashion Jungle:Some Preliminary Trailblazing显示文摘 | CARSON P P LANIER P A CARSON K D | 2000 | Academy of Management Journal2000，43，6： | 1 |
| 13 | Functional mapping of an AcNPV immediate early gene which augments expression of the IE-1 transactivated 39k gene显示文摘 | Carson D D Guarino L A Summers M O | 1988 | Virology1988，162，： | 1 |
| 14 | Effect of supplementation with barium selenate on the fertility, prolificacy and lambing performance of hill sheep 显示文摘 | Mufioz C Carson A F McCoy M A Dawson L E Irwin D Gordon A W Kilpatriek D J | 2009 | The Veterniary Record2009，164，9： | 1 |
| 15 | Transient expression of the Autographa californica nuclear polyhedrosis virus immediate-early gene,IE-N,is regulated by three viral elements显示文摘 | Carson D D Summers M D Guarino L A | 1991 | J Virol1991，65，： | 1 |
| 16 | Expression profilingof cytokinin action in Arabidopsis显示文摘 | RASHOTTE A M CARSON S D B TO J P C | 2003 | Plant Physiol2003，132，： | 1 |
| 17 | Apoptosis and disease显示文摘 | Carson D A Ribeiro J M | 1993 | Lancet1993，341，8855： | 1 |
| 18 | Disaster 101:A Novel Approach to Disaster Medicine Training for Health Profes- sionals显示文摘 | Scott L A Carson D S Greenwell I B | 2010 | J Emerg Med2010，39，2： | 1 |
| 19 | Clearing a path through the Management Fashion Gunglc: Some Preliminary Trailblazing 显示文摘 | CARSON P P LANIER P A CARSON K D | 2006 | Academy of Management Journal2006，43，6： | 1 |
| 20 | Effect of neuropeptides on production of inflammatory cytokines by human monocyt- es显示文摘 | Lotz M Vaughan J H Carson D A | 1988 | Science1988，241，4870： | 1 |
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