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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings显示文摘 | Adler D D Carson P L Rubin J M | 1990 | Ultrasound MedBiol1990，16，6： | 1 |
| 3 | Doppler ultrasound flow imaging in the study of breast cancer:Preliminary findings显示文摘 | Alder D D Carson P L Rubin J M | 1990 | UItrasound Med Biol1990，16，6： | 1 |
| 4 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings显示文摘 | Alder D D Carson P L Rubin J M | 1990 | Ultrasound Med boi11990，16，4： | 1 |
| 5 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings 显示文摘 | ADLER D D CARSON P L RUBIN J M | 1990 | Utrasound Med Biol1990，16，： | 1 |
| 6 | Doppler ultrasound flowimaging in the study of breast cancer:preliminary findings显示文摘 | Adler D D Carson P L Rubin J M | | 0，，06： | 1 |
| 7 | Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter显示文摘 | Guzman LM Belin D Carson M J | 1995 | Journal of Bacteriology1995，177，14： | 1 |
| 8 | Apoptosis and disease显示文摘 | Carson D J M Ribeiro | 1993 | Lancet1993，341，： | 1 |
| 9 | Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma 显示文摘 | Hedvat M Jain A Carson D A st al | 2004 | Cancer Cell2004，5，6： | 1 |
| 10 | Doppler ultrasound color flow imaging in the study of breast cancer: preliminary findings 显示文摘 | Adler D D Carson P L Rubin J M | 1990 | Ultrasound MedBiol1990，16，6： | 1 |
| 11 | Doppler ultrasound color flow imaging in the study of breast cancer:Preliminary findings显示文摘 | Alder D D Carson P L Robin J M | 1990 | Ultrasond Med Biol1990，16，： | 1 |
| 12 | Cutting edge:estrogen drives expansion of the CD+4CD+25 regulatory T cell compartment显示文摘 | POLANCZYK M J CARSON B D SUBRAMANIAN S | 2004 | J Immunol2004，173，： | 1 |
| 13 | Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter显示文摘 | Guzman L M Belin D Carson M J | 1995 | J Bacteriol1995，177，14： | 1 |
| 14 | Functional mapping of an AcNPV immediate early gene which augments expression of the IE-1 transactivated 39k gene显示文摘 | Carson D D Guarino L A Summers M O | 1988 | Virology1988，162，： | 1 |
| 15 | Effect of supplementation with barium selenate on the fertility, prolificacy and lambing performance of hill sheep 显示文摘 | Mufioz C Carson A F McCoy M A Dawson L E Irwin D Gordon A W Kilpatriek D J | 2009 | The Veterniary Record2009，164，9： | 1 |
| 16 | Transient expression of the Autographa californica nuclear polyhedrosis virus immediate-early gene,IE-N,is regulated by three viral elements显示文摘 | Carson D D Summers M D Guarino L A | 1991 | J Virol1991，65，： | 1 |
| 17 | Doppler ultrasoud color flow imaging in the dtudy of breast cancer: preliminary finding 显示文摘 | ADLER D D CARSON P L RUBIN J M | 1990 | Ultrasoud Med Biol1990，16，： | 1 |
| 18 | Expression profilingof cytokinin action in Arabidopsis显示文摘 | RASHOTTE A M CARSON S D B TO J P C | 2003 | Plant Physiol2003，132，： | 1 |
| 19 | Apoptosis and disease显示文摘 | Carson D A Ribeiro J M | 1993 | Lancet1993，341，8855： | 1 |
| 20 | Doppler ultrasound flow imaging in the study of breast cancer: preliminary finding 显示文摘 | Alder D D Carson P L Rubin J M | 1990 | Ultrasound Meal Biol1990，16，： | 1 |
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