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| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Analysis of peridural scar formation and its prevention after lumbar laminotomy and discectomy in dogs显示文摘 | SONGER M N RAUSCHNING W CARSON E W | 1995 | Spine1995，20，5： | 1 |
| 3 | Drought stress and tropical for-est woody seedlings:Effect on community structure and composi-tion显示文摘 | BUNKER D E CARSON W P | 2005 | Journal of Ecology2005，93，4： | 1 |
| 4 | Reversible mid- dle cerebral artery occlusion without cranieetomy in rats 显示文摘 | Longa E Z W einstein P R Carson S | 1989 | Stroke1989，20，1： | 1 |
| 5 | The Importance of Storage, Transfer and Collection 显示文摘 | KNOWLTON T M CARSON J W KLINZING G E | 1994 | Chemical Engineering Progress1994，90，1： | 1 |
| 6 | Atrial fibrillation in pregnancy associated with oral terbutaline显示文摘 | Carson M P Fisher A J Scorza W E | 2002 | Obstet Gynecol2002，100，5： | 1 |
| 7 | WACS-Wide-area stability and voltage control system: R and D and online demonstration 显示文摘 | Taylor Carson W Erickson Dennis C Martin Kenneth E | 2005 | Proceedings of the IEEE2005，93，5： | 1 |
| 8 | Effect of supplementation with barium selenate on the fertility, prolificacy and lambing performance of hill sheep 显示文摘 | Mufioz C Carson A F McCoy M A Dawson L E Irwin D Gordon A W Kilpatriek D J | 2009 | The Veterniary Record2009，164，9： | 1 |
| 9 | Genome sequence of Streptococcus mutans UA159,a cariogenic dental pathogen 显示文摘 | Ajdic D McShan W M McLaughlin R E Savie G Chang J Carson M B | 2002 | Proc Natl Aead Sci USA2002，99，14： | 1 |
| 10 | Meeting Re port:The 13th Annual Meeting of the Translational Research Cancer Centers Consortium (TrC3) ; Immune Suppression and the Tumor Microenvironment,Columbus,Ohio; March 1 2,2010显示文摘 | Lesinski G B Carson W E Repasky E A | 2010 | Journal of Immunotherapy2010，33，7： | 1 |
| 11 | Interleuldn IL - 15 is a novel cytokine that activates human natural killer cells via compo- nents of the IL - 2 receptor显示文摘 | Carson W E Lindemann 1~1 J Linett M L | 1994 | J Exp Ned1994，180，： | 1 |
| 12 | In- dications for cardiac resynchronization therapy: 2011 up- date from the Heart Failure Society of America Guideline Committee显示文摘 | Stevenson W G Hernandez A F Carson P E | 2012 | J Card Fail2012，18，2： | 1 |
| 13 | The c -Kit Lig- and Suppresses Apoptosis of Human Natural Killer Cells Through the Upregulation of bcl-2 显示文摘 | CARSON W E HALDAR S BAIOCCHI R A | 1994 | Proc Natl Acad Sci USA1994，91，16： | 1 |
| 14 | Clinical and genetic aspects of primary ciliary dyskinesia/Kartagener syndrome显示文摘 | Leigh M W Pittman J E Carson J L | 2009 | Genet Med2009，11，7： | 1 |
| 15 | Reversi-blem iddle cerebral artery occlusion without crainieto-my in rats显示文摘 | Longa E Z W einstein P R Carson S | 1989 | Stroke1989，20，1： | 1 |
| 16 | CpG-containing oligodeoxynucleotides act through TLR9 to enhance the NK cell cytokine response to antibody-coated tumor cells显示文摘 | Roda J M Parihar R Carson W E | 2005 | J Immunol2005，175，3： | 1 |
| 17 | Effectiveness of medical resident education in mechanical ventilation显示文摘 | Cox C E Carson S S Ely E W | 2003 | Am J Respir Crit Care Med2003，167，1： | 1 |
| 18 | Revision anterior cruciate ligament reconstruction:etiology of failuares and clinical results显示文摘 | CARSON E W ANISKO E M RESTREPO C | 2004 | J Knee Surg2004，17，： | 1 |
| 19 | A comparison of forest canopy models derived from LIDAR and INSAR data in a Pacific Northwest conifer forest 显示文摘 | Andersen H E McGanghey R J Carson W W | 2004 | International Archives of Photogrammetry and Remote Sensing2004，34，3： | 1 |
| 20 | The importance of storage,transfer and collection显示文摘 | Knowlton T M Carson J W Klinzing G E | 1994 | Chemical Engineering Progress1994，90，1： | 1 |
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