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| 1 | Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients显示文摘AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected patients.METHODS Single nucleotide polymorphisms(SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank < 50 g ethanol/day. Diverse SNPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP a.RESULTS A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. None of the six SNPs evaluated had any significant association with liver fibrosis ≥ F2.CONCLUSION Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis in HIVinfected patients with/without HCV coinfection. | Julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina Angel-Hugo Montes José A Cartón Víctor Asensi | 2017 | World Journal of Virology2017，6，2： | 3 |
| 2 | Review and simulation of homoplasy and collision in AFLP显示文摘 | CART G EEUWIJK F A V | 2012 | Euphytica2012，183，3： | 1 |
| 3 | Evaluation of a home-based exercise and training programme to improve sit-to-stand in patients with chronic stroke显示文摘 | Monger C Cart JH Fowler V | 2002 | Clin Rehabil2002，16，4： | 1 |
| 4 | A proposal for construction project risk assessment using fuzzy logic 显示文摘 | Tha J H Cart V | 2000 | Construction Management and Econom- ics2000，，18： | 1 |
| 5 | Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway显示文摘 | Krishnamoorthy V Cart T De Poorer RF | | J Immunol0，194，7： | 1 |
| 6 | Information modeling for a construc- tion project risk management system 显示文摘 | Tah J H M Cart V | 2000 | Engineering Construction and Architectural Management2000，7，2： | 1 |
| 7 | Evaluation of sex-typed tacks by black men and women显示文摘 | Cart P G Thomas V G Mednick M T | 1985 | Sex Roles1985，13，： | 1 |
| 8 | Alteration of β-tubulin gene expression during low-temperature exposure in leaves of arabidopsis thaliana显示文摘 | CHU B SNUSTAD D P CART J V | 1993 | Plant Physicol1993，103，： | 1 |
| 9 | An MRI study of subgenual prefrontal cortex in patients with familial and non- familial bipolar I disorder 显示文摘 | Sharma V Menon R Cart TJ | 2003 | J Affect Disord2003，77，2： | 1 |
| 10 | Food web structure of deep-sea macrozooplankton and micronekton off theCatalan slope: Insight from stable isotopes 显示文摘 | FANELLI E CARTES J E PAPIOL V 2011 | 2011 | Journal of Marine Systems2011，87，： | 1 |
| 11 | Ageometric model for active eontours显示文摘 | Caselles V Carte F Coll T | 1993 | Numerische Mathematik1993，66，： | 1 |
| 12 | Towards a framework for project risk knowledge management in the construction supply chain显示文摘 | Tah J H M Cart V | 2001 | Ad- vances in engineering software2001，32，： | 1 |
| 13 | The water relations and irrigation requirments of coffee 显示文摘 | Cart M K V | 2002 | Experimental Agriculture2002，37，1： | 1 |
| 14 | Neuromyelitis optica and pulmonary tuberculosis: a case-control study 显示文摘 | Zatjirua V Butler J Cart J | 2011 | Int J Tuberc Lung Dis2011，15，12： | 1 |
| 15 | Towards a framework for project risk knowledge management in the construction supply chain显示文摘 | Tah J H M Cart V | 2001 | Advances in Engineering Software2001，32，1011： | 1 |
| 16 | A Geometric Model for Active Contours in Image Processing 显示文摘 | Caselles V Carte F Coll T | 1993 | Numerische Mathematik1993，66，1： | 1 |
| 17 | Knowledge-based approach to construction project risk management 显示文摘 | Tah J H M Cart V | 2001 | Joumal of Computing in Civil Engineering2001，15，3： | 1 |
| 18 | A Simple and Reliable Inmaunohistochemical Method for Colocalization of 2 Antigens in the Same Cells of Paraffin - embedded Tissues 显示文摘 | Yan J Carts V S Chan A | 2012 | Appl Immunohistochem Mol Morphol2012，，： | 1 |
| 19 | A geometric model for active contours in image processing 显示文摘 | Caselles V Carte F Coll T | 1993 | Numerische Mathematik1993，66，1： | 1 |
| 20 | A geometric model for activecontours in image processing显示文摘 | CASELLES V CARTE F COIL T | 1993 | Numerische Mathmatik1993，66，1： | 1 |
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