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| 1 | Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals显示文摘ASXL1 变化经常在 hematological 肿瘤被发现,并且 Asxl1 的损失在老鼠支持 myeloid 转变。这里我们在 vivo 在在 Histone H2A (H2AK119ub1 ) 上的 mono-ubiquitylated 离氨酸 119 的 deubiquitylation 为 ASXL1-BAP1 建筑群支持一个角色的现在的数据。Polycomb 组蛋白质在正常开发期间控制 INK4B-ARF-INK4A 地点的表达式,部分地通过催化 H2AK119 的 mono-ubiquitylation。自从地点的激活, INK4B-ARF-INK4A 玩一设有自动保险装置机制免于 tumorigenesis,我们调查了 ASXL1 依赖的 H2A deubiquitylation 是否在它的激活起一个作用。有趣地,我们发现 ASXL1 明确地为 p15 响应 oncogenic 发信号和外来的 anti-proliferative 的 INK4B 发信号。因为我们发现 ASXL1 和 BAP1 两个都在 INK4B 地点被充实,我们的结果建议 INK4B 地点的激活要求 H2AK119ub1 的 ASXL1/BAP1-mediated deubiquitylation。一致地,我们 ASXL1 变化与被联系的结果表演降低 p15 INK4B 和在主要骨头髓房间的造血的祖先的一个 proliferative 优点,和在多重房间线的 ASXL1 的那弄空导致抵抗到生长禁止的信号。一起拿,这研究连接 INK4B 表示的调停 ASXL1 的 H2A deubiquitylation 和 transcriptional 激活到它的肿瘤 suppressor 函数。 | Xudong Wu Ida Holst Bekker-Jensen Jesper Christensen Kasper Dindler Rasmussen Simone Sidoli Yan Qi Yu Kong Xi Wang Yajuan Cui Zhijian Xiao Guogang Xu Kristine Williams Juri Rappsilber Casper Kaae Sonderby Ole Winther Ole N Jensens Kristian Helin | 2015 | Cell Research2015，25，11： | 3 |
| 2 | Drought prolongs leaf life span in the herbaceous desert perennial Cryptantha flava显示文摘 | CASPER B B FORSETH I N KEMPENICH H | 2001 | Functional Ecology2001，15，6： | 1 |
| 3 | HLA-G expression during preimplantation human embryo development 显示文摘 | Jurisicova A Casper RF MacLusky N J | 1996 | Proc Natl Acad Sci USA1996，93，1： | 1 |
| 4 | ' Making all the difference in the world' : How physicians can help HIV se- ropositive patients become more involved in their health care 显示文摘 | Gerbert B Love C Caspers N | 1999 | AIDS PATIENT CARE and STDs1999，13，1： | 1 |
| 5 | Addition of low dose hCG to rFSh benefits older women during ovarian stimulation for IVF 显示文摘 | Gomaa H Casper RF Esfandiari N | 2012 | Re- prod Biol Endocrino12012，10，： | 1 |
| 6 | Endometriosis: diagnosis and management显示文摘 | Leyland N Casper R Laberge P | 2010 | J Obstet Gynaecol Can2010，32，72： | 1 |
| 7 | Characterization of the first cell cycle in human zygotes:Implication for cryopreservation显示文摘 | Balakier H MacLusky N J Casper RF | 1993 | Fertil Steril1993，59，2： | 1 |
| 8 | The prognostic significance of acute phase proteins in patients with inoperable squamous cell carcinoma of the bronchus 显示文摘 | Caspers R J Pidcock N B Cooper E H | 1984 | Radiotherapy Oncology1984，2，2： | 1 |
| 9 | HLA-G expression during preimplantation human embryo development显示文摘 | JURISICOVA A CASPER R F MACLUSKY N J | 1996 | Proc Natl Acad Sci U S A1996，93，1： | 1 |
| 10 | Embryonic human leukocyte antigen-G expression:possible implications for human preimplantation development显示文摘 | JURISICOVA A CASPER R F MACLUSKY N J | 1996 | Fertil Steril1996，65，5： | 1 |
| 11 | Endometriosis:diagnosis and management显示文摘 | Leyland N Casper R Laberge P | 2010 | J Obstet Gynaecol Can2010，32，72： | 1 |
| 12 | Controlling Surface Morphology of Electrospun Polystyrene Fibers: Effect of Humidity and Molecular Weight in the Electrospinning Process 显示文摘 | Casper C L Stephens J S Tassi N G | 2004 | Macromolecules2004，37，2： | 1 |
| 13 | Endometriosis:di-agnosis and management 显示文摘 | Leyland N Casper R Laberge P | 2010 | J Obstet Gynaecol Can2010，32，72： | 1 |
| 14 | Drought prolongs leaf life span in the herbaceous desert perennial Cryptantha flava显示文摘 | CASPER B B FORSETH I N KEMPENICH H | 2001 | Functional Ecology2001，15，6： | 1 |
| 15 | In Whose Home?Multigenerational Families in the United States,1998-2000显示文摘 | Philip N Cohen Lynne M Casper | | 0，，01： | 1 |
| 16 | Seminal hyperviscosity is asseciated with poor outcome of controlled ovarian stimulation and intrauterine insemination:a prospective study显示文摘 | ESFANDIARI N GOTLIEB L CASPER R F | 2006 | Int J Fertil Womens Med2006，51，1： | 1 |
| 17 | Shading by shrubs in a desert system reduces the physiological and demographic performance of an associated herbaceous perennial 显示文摘 | Forseth I N Wait D A Casper B B | 2001 | Journal of Ecology2001，89，： | 1 |
| 18 | Functionalizing Electrospun Fibers with Biologically Relevant Macromolecules显示文摘 | Casper CL Yamaguchi N Kiick KL Rabolt JF | 2005 | Biomacromolecules2005，6，： | 1 |
| 19 | A stage-based study of drought response in Cryptantha flava (Boraginaceae): Gas exchange, water use efficiency, and whole plant performance 显示文摘 | Casper B B Foresth I N Wait D A | 2006 | American Journal of Botany2006，93，7： | 1 |
| 20 | Controlling surface morphology of electrospun polystyrene fibers: effect of humidity and molecular weight in the electrospinning process显示文摘 | Casper C L Stephens J S Tassi N G | 2004 | Macrol Dolecules2004，37，： | 1 |
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