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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation显示文摘 | Castillo T Koop D R Kamimura S | 1992 | Hepatology1992，16，4： | 2 |
| 3 | Structural, optical and electrical characterization of In/CdS/glass thermally annealed system 显示文摘 | Mendoza-Galvan A Ramirez-Bon R | 2000 | Thin Solid Films2000，373，： | 1 |
| 4 | Interactive effects of ozone and drought stress on pigments and activities of antioxidantive enzymes in Pinus halepensis 显示文摘 | Alonso R Elvira S Castillo F J | 2001 | Plant Cell Environ2001，24，： | 1 |
| 5 | Study of solid contamination in ball bearings through vibration and wear analyses显示文摘 | M M Maru R S Castillo L R Padovese | 2007 | Tribology International2007，40，3： | 1 |
| 6 | Oleic and doc- osahexaenoic acid differentially phase separate from lipid raft mole- cules: a comparative NMR, DSC, AFM, and detergent extraction study 显示文摘 | SHAIKH S R DUMAUAL A C CASTILLO A | 2004 | Biophysical Journal2004，87，3： | 1 |
| 7 | Physicochem~cal, structural, and digesti~ihty properties of enzymatic modified plantain and mango starches 显示文摘 | Casarrubias- Castillo M G Hamaker B R Rodriguez-Ambriz S L Be~o-P~rez L A_ | 2012 | Starch/Starke2012，64，4： | 1 |
| 8 | Nortriptyline versus fluoxetine in the treatment ofdepression and in short-term recovery after stroke:A placebo-controlled,double-blind study显示文摘 | Schultz S Castillo C | 2000 | Am J Psychiatry2000，157，： | 1 |
| 9 | Contribution of disulfide bonds to stability, folding, and amyloid fibril formation显示文摘 | Graha-Montes R de Groot N S Castillo V eta| | 2012 | Antioxid Redox Sig- nal2012，，： | 1 |
| 10 | Mucin- producing neoplasms of the pancreas: an analysis of distinguishing clinical and epidemiologic characteristics 显示文摘 | Crippa S Fern6ndez-Del Castillo C Salvia R | 2010 | Clin Gastroenterol Hepatol2010，8，2： | 1 |
| 11 | Potential of particle and fibre reinforcement of tyre tread elastomers显示文摘 | RJOS S CHICUREL R DEL CASTILLO L F | 2001 | Materials and Dcsign2001，22，： | 1 |
| 12 | On the response of pigments and antioxidants of Pinus halepensis seedlings to Mediterranean climatic factors and long-term ozone exposure显示文摘 | Elvira S Alonso R Castillo F J | 1998 | New Phytologist1998，138，3： | 1 |
| 13 | Physicochemical, structural, and digestibility properties of enzymatic modified plantain and mango starches 显示文摘 | Casarrubias- Castillo M G Hamaker B R Rodriguez-Ambriz S L BeUo-P~rez L A | 2012 | Starch-Starke2012，64，4： | 1 |
| 14 | A distinct lineage of influenza A virus from bats显示文摘 | Tong S Li Y Rivailler P Conrardy C Castillo D A Chen L M Recuenco S Ellison J A Davis C T York I A Turmelle A S Moran D Rogers S Shi M Tao Y Weil M R Tang K Rowe L A Sammons S Xu X Frace M Lindblade K A Cox N J Anderson L J Rupprecht C E Donis R O | 2012 | PANS2012，109，11： | 1 |
| 15 | Proton MR speetroseopy of the brain 显示文摘 | Maheshwari S R Fatterpekar G M Castillo M | 2000 | Semin Untrasound CT MR2000，21，6： | 1 |
| 16 | Optimal traffic plate scanning location for OD trip matrix and route estimation in road networks 显示文摘 | Minguez R SOnchez-Cambronero S Castillo E | 2010 | Transporta- tion Research Part B: Methodological2010，44，2： | 1 |
| 17 | Miso- prostol preferable to ethacridine lactate for abortions at 13- 20 weeks of pregnancy: Cuban experience 显示文摘 | BOZA A V DE LEON R G CASTILLO L S | 2008 | Reprod Health Matters2008，16，31： | 1 |
| 18 | Anti-endothelial cell re- activity,the unresolved enigma显示文摘 | Castillo S Revelen R Bordron A | 2001 | Int J Immunopathol Pharma- col2001，14，2： | 1 |
| 19 | Study ofSolid Contamination in Ball Bearings through Vi-bration and Wear Analyses显示文摘 | Maru M M Castillo R S Padvese L R | 2007 | Tribology Interna-tional2007，40，3： | 1 |
| 20 | Structural, optical and electrical characterization of In/CdS/glass thermally annealed system显示文摘 | Mendoza-Galvan A Ramirez-Bon R | 2000 | Thin Solid Films2000，373，： | 1 |
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