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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | In situ study of austenite formation by dilatometry in a low carbon microalloyed steel显示文摘 | Martin D S Rivera-Dlaz-del Castillo P E J Garcia de-Andres C | 2008 | Scripta Materialia2008，58，10： | 1 |
| 3 | Structural, optical and electrical characterization of In/CdS/glass thermally annealed system 显示文摘 | Mendoza-Galvan A Ramirez-Bon R | 2000 | Thin Solid Films2000，373，： | 1 |
| 4 | Interactive effects of ozone and drought stress on pigments and activities of antioxidantive enzymes in Pinus halepensis 显示文摘 | Alonso R Elvira S Castillo F J | 2001 | Plant Cell Environ2001，24，： | 1 |
| 5 | A second conserved GAF domain cysteine is required for the blue/green photoreversibility of cy- anobacteriochrome TIr0924 from Thermosynecho- coccus elongates 显示文摘 | Rockwell N C Njuguna S L Roberts L Castillo E Parson V L Dwojak S Lagarias J C Spiller S C | 2008 | Biochemistry2008，47，： | 1 |
| 6 | Efficacy of 1-MCP Treatment in Tomato Fruit显示文摘 | GUILLEN F CASTILLO S ZAPATA P J | 2007 | Postharvest Biology and Technology2007，43，： | 1 |
| 7 | Dose-dependent decrease of activation in bilateral amygdala and insula by lorazepam during emotion processing 显示文摘 | Paulus M P Feinstein J S Castillo G | 2005 | Arch Gener Psychiatry2005，62，3： | 1 |
| 8 | Polishing pad surface morphology and chemical mechanical planarization 显示文摘 | Castillo M D Kelchner J Beaudoin S | 2004 | Journal of the Electrochemical Society2004，151，4： | 1 |
| 9 | A combined optimization of alloy composition and aging temperature in designing new UHS precipitation hardenable stainless steels显示文摘 | Xu W Rivera Diaz del Castillo P E J van der Zwaag S | 2009 | Computational Materials Science2009，45，2： | 1 |
| 10 | Predictors of sudden death in coronary artery disease显示文摘 | Serrano Sanchez JA del Castillo Arrojo S | 2000 | Rev Esp Cardiol2000，53，3： | 1 |
| 11 | Designing nanoprecipitation strengthened UHS stainless steels combining genetic algorithms and thermodynamics 显示文摘 | Xu W Rivera Diaz del Castillo P E J van der Zwaag S | 2008 | Computational Materials Science2008，44，2： | 1 |
| 12 | Use ofmannanoligosaccharides and zinc chelate as growth promotersand diarrhea preventative in weaning pigs:Effects on microbiotaand gut function显示文摘 | Castillo M Martín-Orúe S M Taylor-Pickard J A | 2008 | Journal of Animal Science2008，86，1： | 1 |
| 13 | Tools to maintain postharvest fruit and vegetable quality through the inhibition of ethylene action: a review显示文摘 | MARTINEZ-ROMERO D BALIEN G SERRANO M GUILLENF VALVERDE J M ZAPATA P CASTILLO S VALERO D | 2007 | Critical Reviews in Food Science and Nutrition2007，47，： | 1 |
| 14 | Exercise when young provides lifelong benefits to bone structure and strength 显示文摘 | Warden S J Fuchs RK Castillo AB | 2007 | Journal of Bone and Mineral Research2007，22，2： | 1 |
| 15 | Dealing with Error Recovery in Traffic Flow Prediction Using Bayesian Networks Based on License Plate Scanning Data 显示文摘 | S Sdnchez-Cambronero E Castillo J M Men6ndez P Jim6nez | 2010 | Journal of Transportation Engineering2010，，6： | 1 |
| 16 | First report of Macrophomina phaseolina causing crown and root rot of strawberry in Spain显示文摘 | Avilés M Castillo S Bascon J | 2008 | Plant Pathology2008，57，： | 1 |
| 17 | On the response of pigments and antioxidants of Pinus halepensis seedlings to Mediterranean climatic factors and long-term ozone exposure显示文摘 | Elvira S Alonso R Castillo F J | 1998 | New Phytologist1998，138，3： | 1 |
| 18 | Hepatitis B infection increases the risk of non-Hodgkin lymphoma:A meta-analysis of observational studies显示文摘 | DALIA S CHAVEZ J CASTILLO J J | 2013 | Leuk Res2013，37，： | 1 |
| 19 | Growth and nutrient removal in free and immobilized planktonic green algae isolated from pig manure显示文摘 | PEREZ M V J CASTILLO P S ROMERA O | 2004 | Enzyme and Microbial Technology2004，34，： | 1 |
| 20 | Mini rotorcraft flight formation control using bounded inputs显示文摘 | Guerrero J A Castillo P Salazar S | 2012 | J of Intelligent and Robotic Systems: Theory and Applications2012，65，1234： | 1 |
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