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| 1 | Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered显示文摘AIM: To study the blood-brain barrier integrity in prehe-patic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 d after ligation when portal pressure is spontaneously normalized. METHODS: Adult male Wistar rats were divided into four groups: GroupⅠ: Sham14d, sham operated; GroupⅡ: PH14d, portal vein stenosis; (both groups were used 14 days after surgery); GroupⅢ: Sham40d, Sham operated and GroupⅣ: PH40d Portal vein stenosis (GroupsⅡandⅣused 40 d after surgery). Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS: Forty days after stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION: The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility, Hemo-dynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment. | Francisco Eizayaga Camila Scorticati Juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg Juan C Perazzo | 2006 | World Journal of Gastroenterology2006，12，9： | 3 |
| 2 | Optimisation of shape and process parameters in metal forging using genetic algorithms显示文摘 | CASTRO C F ANTONIO C A C SOUSA L C | 2004 | Journal of Material Processing Technology2004，146，3： | 1 |
| 3 | Propolis: recent advances in chemistry and plant origin显示文摘 | BANKOVA V S DE CASTRO S L MARCUCI M C | 2000 | Apidologie2000，31，： | 1 |
| 4 | PROSITE,aprotein domain database for functional characterization and anno-tation显示文摘 | S IGRIST C J A CERUTTI L de CASTRO E | 2010 | Nucleic Acids Research2010，38，1： | 1 |
| 5 | Informational net- works and innovation in mature industrial clusters 显示文摘 | Casanueva C Castro I GalOn J L | 2013 | Journal of Business Research2013，66，5： | 1 |
| 6 | Yield and composition of the essential oil of Ocimum selloi Benlh cultivated under colored netting显示文摘 | Costa L C B Pinto J E B P Castro E M | 2010 | Journal of Essential Oil Research2010，22，1： | 1 |
| 7 | Application of catalytic hydropyrolysis for the rapid preparation of linin comcentrates from wood显示文摘 | Beramendi L E Castro M Snape C E | 2004 | Organic Geochemistry2004，35，1： | 1 |
| 8 | Identification of anovel antimicrobial peptide from Brazilian coast coral Phyllogorgiadilatata显示文摘 | de Lima LA Migliolo L Barreiro e Castro C | 2013 | Protein Pept Lett2013，20，10： | 1 |
| 9 | A neutralizing recombinant single chain antibody, scFv, against BaP1, A P-I hemorrhagic metalloproteinase from Bothrops asper snake venom 显示文摘 | CASTRO J M OLIVEIRA T S SILVEIRA C R l | 2014 | Toxicon2014，87，1： | 1 |
| 10 | New dimerie surfactants from alkyl glucosides显示文摘 | J L Castro Mariano J Kovensky C A Fernandez | 1999 | Tetrahedron1999，55，12： | 1 |
| 11 | Gynogenesis assessment using microsatellite genetic markers in turbot ( Scophthalmus maximus )显示文摘 | Castro J Bouza C Sanchez L | 2003 | Mar Biotechnol2003，5，： | 1 |
| 12 | Effect of container o- penings and airflow on energy required for forced air cool- ing of horticultural produce 显示文摘 | Castro (de) L R C Vigneault | 2005 | Canadian Biosystems En- gineering2005，47，： | 1 |
| 13 | Effect of container opening area on air distribution during precooling produce 显示文摘 | Castro de L R Vigneauh C Cortez L A B | 2004 | Transactions of the ASAE2004，47，6： | 1 |
| 14 | A systems approach for the estimation of the effects of land consolidation projects (LCPs) :a model and its application 显示文摘 | CASTRO C J AGUIAR P P MIRA D S L | 2001 | Agricultural Systems2001，68，3： | 1 |
| 15 | Correlation between valsalva leak point pressure and maximal urethral closure pressure in women with stress urinary incontinence 显示文摘 | Feldner P C Jr Bezerra L R de Castro R A | 2004 | Int Urogynecol J Pelvic Floor Dysfunct2004，15，3： | 1 |
| 16 | Parameterized fast deeoupled power flow methods for obtaining the maximum loading point of power systems Part Ⅰ and Part Ⅱ显示文摘 | Alves D A Da Silva L C P Castro C A | 2004 | Electric Power Systems Research2004，69，： | 1 |
| 17 | Effect of heat- moisture treatment on rice starch of varying amylose content显示文摘 | Zavareze E R Storck C R Castro L A S | 2010 | Food Chemistry2010，121，2： | 1 |
| 18 | Quantifying mortality of tropical rain forest trees using high-spatial-resolution satellite data显示文摘 | Clark D B Castro C S Alvarado L D A | | 0，，1： | 1 |
| 19 | Cooling performance of horticultural produce in containers with peripheral openings 显示文摘 | Castro de L R Vigneault C Cortez L A B | 2005 | Postharvest Biology and Technology2005，38，3： | 1 |
| 20 | Atmospheric noble gas signatures in deep Michigan Basin brines as indicators of a past thermal event显示文摘 | MA L CASTRO M C HALL C M | 2009 | Earth and Planetary Science Letters2009，277，： | 1 |
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