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| 1 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 2 | Learning and optimization using the clonal selection 显示文摘 | De Castro L N Zuben V | 2002 | Artificial Immune System (AIS)2002，6，3： | 1 |
| 3 | Propolis: recent advances in chemistry and plant origin显示文摘 | BANKOVA V S DE CASTRO S L MARCUCI M C | 2000 | Apidologie2000，31，： | 1 |
| 4 | Mechanical and Mi crostructural Behavior of Y2O3 ODS EUROFER 97显示文摘 | Castro V de Leguey T Munoz A | 2007 | Journal of Nuclear Materials2007，367，370： | 1 |
| 5 | Target-controlled infusion for remifentanil in vascular patients improves hemodynamics and decreases remifentanil requirement显示文摘 | De Castro V Godet G Mencia G | 2003 | Anesth Analg2003，96，： | 1 |
| 6 | Qualitative and quantitative evalution of mitral valve morphology by intracoperative volume-rendered three-dimensional echocardiography显示文摘 | De Castro S Salandic V Cartoni D | 2002 | Heart Valve Dis2002，11，9： | 1 |
| 7 | Polymethoxylated flavones and other phenolic derivates from citrus in their inhibitory effects on P-glycoprotein-mediated transport of talinolol in Caco-2 cells显示文摘 | Mertens-Talcott S U De Castro W V Manthey J A | 2007 | Journal of Agricultural and Food Chemistry2007，55，7： | 1 |
| 8 | Target-controlled infusion for remifentanil in vascular patients improves hemodynamics and decreases remifentnail requirement显示文摘 | De Castro V Godet G Mencia G | | 0，，01： | 1 |
| 9 | Keeping quality and prolonging the postharvest longevity of spray chrysanthemum CV显示文摘 | FLOREZ-RONCANCIO V J de CASTRO C E F DEMATTE M | 1996 | White Polarisl Bragantia1996，55，2： | 1 |
| 10 | Learning and optimization using the clonal selection principle 显示文摘 | de Castro L N Zuben F J V | 2002 | IEEE Transactions on Evolutiorulry Computation2002，6，3： | 1 |
| 11 | Target-controlled infusion for remifentanil in vascular patients improves hemodynamies and decreases remifentanil requirement显示文摘 | De Castro V Godet G Mencia G | 2003 | Anesth Analg2003，96，： | 1 |
| 12 | Target-controlled infusion for remifentanil in vascular patients improves hemodynamics and de- creases remifentnail requirement 显示文摘 | De Castro V Godet G Mencia G | 2003 | Anesth Analg2003，96，1： | 1 |
| 13 | Extended diamondoid assessment in crude oil using comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry显示文摘 | Silva R C Silva R S F de Castro E V R | 2013 | Fuel2013，112，： | 1 |
| 14 | Target-controlled infusion for remifentanil in vascular patients improves hemodynamics and decreases remifentanil requirement显示文摘 | De Castro V Godet G Mencia G | 2003 | Anesth Analg2003，96，1： | 1 |
| 15 | Assessment of the'golden proportion'in agreeable smiles显示文摘 | De Castro M V Santos N C Ricardo L H | 2006 | Quintessence Int2006，37，8： | 1 |
| 16 | Interaction of Hydregen H+n Clusters with Thin Carbon Foils显示文摘 | de Castro Faria N V Farizon Mazuy B | 1994 | Phys Rev1994，45，4： | 1 |
| 17 | 查看详情显示文摘 | Lima A M F de Castro V G Borges R S Silva G G | | 0，，02： | 1 |
| 18 | BRAF mutations are associated with some histological types of papiliall thyroid carcinoma显示文摘 | Trovisco V Vieira de Castro I Soares P | 2004 | J Pathol2004，202，2： | 1 |
| 19 | Towards more rational techniques for the isolation of valuable essential oils from plants显示文摘 | Jimenez-Carmona M M Fernandez-Perez V | 1999 | Trends in Analytical Chemistry1999，18，11： | 1 |
| 20 | Micelle formation for improvement of continuous subcritinal water extraction of polycyclic aromatic hydrocarbons in soil prior to high-performance liquid chromatography-fluorescence detection显示文摘 | FERNαNDEZ-PERéZ V LUQUE DE CASTRO M D | 2000 | Journal of Chromatography A2000，902，： | 1 |
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