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| 1 | Laparoscopic liver resection for living donation: Where do we stand?显示文摘In Western countries, living donor liver transplantation(LDLT) may represent a valuable alternative to deceased donor liver transplantation. Yet, after an initial peak of enthusiasm, reports of high rates of complications and of fatalities have led to a certain degree of reluctance towards this procedure especially in Western countries. As for living donor kidney transplantation, the laparoscopic approach could improve patient's tolerance in order to rehabilitate this strategy and reverse the current trend. In this setting however, initial concerns regarding patient's safety and graft integrity, need for acquiring surgical expertise in both laparoscopic liver surgery and living donor transplantation and lack of evidence supporting the benefits of laparoscopy have delayed the development of this approach. Similarly to what is performed in classical resectional liver surgery, initial experiences of laparoscopy have therefore begunwith left lateral sectionectomy,which is performed for adult to child living donation.In this setting,the laparoscopic technique is now well standardized,is associated with decreased donor blood loss and hospital stays and provides graft of similar quality compared to the open approach.On the other hand laparoscopic major right or left hepatectomies for adult-adult LDLT currently lack standardization and various techniques such as the full laparoscopic approach,the hand assisted approach and the hybrid approach have been reported.Hence,even-though several reports highlight the feasibility of these procedures,the true benefits of laparoscopy over laparotomy remain to be fully assessed.This could be achieved through standardization of the procedures and creation of international registries especially in Eastern countries where LDLT keeps on flourishing. | Fran?ois Cauchy Lilian Schwarz Olivier Scatton Olivier Soubrane | 2014 | World Journal of Gastroenterology2014，20，42： | 4 |
| 2 | Metabolic syndrome and non-alcoholic fatty liver disease in liver surgery: The new scourges?显示文摘The aim of this topic highlight is to review relevant evidence regarding the influence of the metabolic syndrome(MS) and its associated liver manifestation, non-alcoholic fatty liver disease(NAFLD), on the development of liver cancer as well as their impact on the results of major liver surgery. MS and NAFLD, whose incidences are significantly increasing in Western countries, are leading to a changing profile of the patients undergoing liver surgery. A MEDLINE search was performed for relevant articles using the key words 'metabolic syndrome', 'liver resection', 'liver transplantation', 'non alcoholic fatty liver disease', 'non-alcoholic steatohepatitis' and 'liver cancer'. On one hand, the MS favors the development of primary liver malignancies(hepatocellular carcinoma and cholangiocarcinoma)either through NAFLD liver parenchymal alterations(steatosis, steatohepatitis, fibrosis) or in the absence of significant underlying liver parenchyma changes. Also, the existence of NAFLD may have a specific impact on colorectal liver metastases recurrence. On the other hand, the postoperative period following partial liver resection and liver transplantation is at increased risk of both postoperative complications and mortality. These deleterious effects seem to be related to the existence of liver specific complications but also higher cardio-vascular sensitivity in a setting of MS/NAFLD. Finally, the long-term prognosis after curative surgery joins that of patients operated on with other types of underlying liver diseases. An increased rate of patients with MS/NAFLD referred to hepatobiliary units has to be expected. The higher operative risk observed in this subset of patients will require specific improvements in their perioperative management. | Francois Cauchy David Fuks Alban Zarzavadjian Le Bian Jacques Belghiti Renato Costi | 2014 | World Journal of Hepatology2014，6，5： | 4 |
| 3 | Selective Policy of No Drain after Pancreaticoduodenectomy Is a Valid Option in Patients at Low Risk of Pancreatic Fistula: A Case-Control Analysis显示文摘 | Chetana Lim Safi Dokmak Fran?ois Cauchy Beatrice Aussilhou Jacques Belghiti Alain Sauvanet | 2013 | World Journal of Surgery2013，，5： | 2 |
| 4 | Performance of PIVKA-II for early hepatocellular carcinoma diagnosis and prediction of microvascular invasion显示文摘 | Nicolas Poté Fran?ois Cauchy Miguel Albuquerque Hélène Voitot Jacques Belghiti Laurent Castera Hervé Puy Pierre Bedossa Valérie Paradis | 2014 | Journal of Hepatology2014，，： | 2 |
| 5 | Optimization of an Hough transform algorithm for the search of a center 显示文摘 | Cauchie Julien Fiolet Valerie Villers Didier | 2008 | Pattern Recognition2008，41，2： | 1 |
| 6 | First line chemotherapy in advanced or metastatic NSCLC显示文摘 | Rinaldi M Cauchi C Gridelli C | 2006 | Ann Oncol2006，17，5： | 1 |
| 7 | A pressure overload model of congestive heart failure in rats显示文摘 | Desjardins S Mueller RW Cauchy MJ | 1988 | Ca- rdiovasc Res1988，22，10： | 1 |
| 8 | Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value 显示文摘 | Cauchi S Meyre D Durand E | 2008 | PLoS ONE2008，3，5： | 1 |
| 9 | Effects of TCF7L2 polymorphisms on obesity in European populations 显示文摘 | CAUCHI S CHOQUET H GUTIERREZ-AGUILAR R | 2008 | Obesity( silver spring)2008，16，2： | 1 |
| 10 | Use of urea for treatment of water retention on hyponatraemic cirrhosis with ascites resistant to diuretic显示文摘 | Deaux G Mols P Cauchi P | 1985 | BMJ1985，290，： | 1 |
| 11 | Use of the analysis of the vol- atile faecal metabolome in screening for colorectal cancer显示文摘 | Batty CA Cauchi M Lourenso C | 2015 | PLoS One2015，10，01： | 1 |
| 12 | A systematic literature review of surgical interventions for limbal stem cell deficiency in humans显示文摘 | Cauchi PA Ang GS Azuara-Blanco A | 2008 | Am J Ophthalmol2008，146，2： | 1 |
| 13 | Multiple fiber-optic du- M-beam UV/VIS system with application to dissolution tes- ting 显示文摘 | Johansson J Cauchi M Sundgren M | 2002 | Journal of Pharmaceutical and Biomedical Analysis2002，29，3： | 1 |
| 14 | A pressure overload model of congestive heart failure in rats 显示文摘 | Desjardins GS Mueller RW Cauchy MJ | 1988 | Cardiovasc Res1988，22，10： | 1 |
| 15 | Multiple fiberoptic dual-beam UV/VIS system with application to dissolution testing显示文摘 | JOHANSSON J CAUCHI M SUNDGREN M | | Journal of Pharmaceutical and Biomedical Analysis0，29，： | 1 |
| 16 | Combined effects of MC4R and FTO common genetic variants on obesity in European general populations 显示文摘 | Cauchi S Stutzmann F Cavalcanti-Proenca C | 2009 | J Mol Med2009，87，5： | 1 |
| 17 | Genetic variant near IRS1 is associated with type 2 diabetes,insulin resistance and hyperinsulinemia显示文摘 | Rung J Cauchi S Albrechtsen A | | 0，，： | 1 |
| 18 | TCFTL2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis 显示文摘 | Cauchi S E1 AY Choquet H | 2007 | J Mol Med (Berl)2007，85，7： | 1 |
| 19 | Psyche and cancer显示文摘 | Lopez M Cauchi C Sergi D | 2010 | Clin Ter2010，161，1： | 1 |
| 20 | Effects of TCF7L2 polymorphisms on obesity in Europe an populations显示文摘 | Cauchi S Choquet H Gutierrez-Aguilar R | 2008 | Obesity( silver spring)2008，16，2： | 1 |
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