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| 1 | Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis显示文摘AIM: To investigate the vasoactive intestinal peptides(VIP) expression in irritable bowel syndrome(IBS) and trinitrobenzene sulfonic acid(TNBS) induced colitis.METHODS: The VIP gene expression and protein plasma levels were measured in adult participants(45.8% male) who met Rome Ⅲ criteria for IBS for longer than 6 mo and in a rat model of colitis as induced by TNBS.Plasma and colons were collected from naive and inflamed rats.Markers assessing inflammation(i.e.,weight changes and myeloperoxidase levels) were assessed on days 2,7,14 and 28 and compared to controls.Visceral hypersensitivity of the rats was assessed with colo-rectal distension and mechanical threshold testing on hind paws.IBS patients(n = 12) were age,gender,race,and BMI-matched with healthy controls(n = 12).Peripheral whole blood and plasma from fasting participants was collected and VIP plasma levels were assayed using a VIP peptide-enzyme immunoassay.Human gene expression of VIP was analyzed using a custom PCR array.RESULTS: TNBS induced colitis in the rats was confirmed with weight loss(13.7 ± 3.2 g) and increased myeloperoxidase activity.Visceral hypersensitivity tocolo-rectal distension was increased in TNBS treated rats up to 21 d and resolved by day 28.Somatic hypersensitivity was also increased up to 14 d post TNBS induction of colitis.The expression of an inflammatory marker myeloperoxidase was significantly elevated in the intracellular granules of neutrophils in rat models following TNBS treatment compared to naive rats.This confirmed the induction of inflammation in rats following TNBS treatment.VIP plasma concentration was significantly increased in rats following TNBS treatment as compared to naive animals(P < 0.05).Likewise,the VIP gene expression from peripheral whole blood was significantly upregulated by 2.91-fold in IBS patients when compared to controls(P < 0.00001; 95%CI).VIP plasma protein was not significantly different when compared with controls(P = 0.193).CONCLUSION: Alterations in VIP expression may play a role in IBS.Therefore,a better understanding of the physiology of VIP could lead to new therapeutics. | Arseima Y Del Valle-Pinero LeeAnne B Sherwin Ethan M Anderson Robert M Caudle Wendy A Henderson | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 2 | Improving miscible displacement by gas-water injection 显示文摘 | Caudle B H Dyes A B | 1959 | Transactions of AIME1959，213，： | 1 |
| 3 | Origin of germ cells and formation of new primary follicles in adult human ovaries显示文摘 | Bukovsky A Caudle Svetlikova M | 2004 | Re- prod Biol Endocrinol2004，2，： | 1 |
| 4 | Abnormal expression of p27 kipl protein in levator animuscle of aging women with pelvic floor disorders-a relationship to the cellular differentiation and degeneration显示文摘 | Bukovsky A Copas P Caudle MR | 2001 | BMC Clin Pathol2001，1，1： | 1 |
| 5 | Steroid-mediated differentiation of neural/neuronal cells from epithelial ovarian precursors in vitro显示文摘 | Bukovsky A Caudle MR Svetlikova M | 2008 | Cell Cycle2008，7，22： | 1 |
| 6 | Obligatory role for complex I inhibition in the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)显示文摘 | Richardson J R Caudle W M Guillot T S Watson J L Nakamaru-Ogiso E Seo B B Sherer T B Greenamyre J T Yagi T Matsuno-Yagi A Miller G W | | 0，，01： | 1 |
| 7 | Formation of new primary follicles in adult human ovaries显示文摘 | Bukovsky A Caudle MR Svetlikova M | 2004 | Reprod Biol Endocrinol2004，2，： | 1 |
| 8 | Multidisciplinary Considerations in the Implementation of the Findings from the American College of Surgeons Oncology Group (ACOSOG) Z0011 Study ; A Practice-Changing Trial 显示文摘 | Caudle A S Hunt K K Kuerer H | 2011 | Ann Surg Oncol2011，18，9： | 1 |
| 9 | Reproductive tract diseases that cause infertility in the bitch显示文摘 | Miller-Liebl D Fayer-Hosken R Caudle A | 1994 | Vet- Med1994，89，： | 1 |
| 10 | CSF HVA,5 HTAA ratio increases with antipsychotic response to clozepine显示文摘 | Risch SC Aden A Caudle J | 1994 | Biol Psychiat1994，35，： | 1 |
| 11 | Origin of germ cells and formation of newprimary follicles in adult human ovaries显示文摘 | Bukovsky A Caudle MR Svetlikova M | 2004 | Reprod Biol Endocrinol2004，2，： | 1 |
| 12 | A novel approach to sexing bovine blastocysts using male-specific gene expression显示文摘 | Hamilton CK Combe A Caudle J | 2012 | Tberiogenology2012，77，8： | 1 |
| 13 | Steroid - mediated differen- tiation of neural/neurenal cells from epithelial ovarian precursors in vitre显示文摘 | Bukovsky A Caudle MR Svetlikova M | 2008 | Cell Cycle2008，7，22： | 1 |
| 14 | Reproductivetract diseases that cause infertility in the bitch显示文摘 | Miller-Lieb D Fayer-Hosken R? Caudle A | 1994 | Vet Med1994，89，： | 1 |
| 15 | Reproductive tract diseases that cause infertility in the bitch显示文摘 | Miller-Liebl D Fayer-Hosken R Caudle A | 1994 | Vet Med1994，89，： | 1 |
| 16 | Steroid-mediated differentiation of neural/neuronal cells from epithelial ovarian precursors in vitro显示文摘 | Bukovsky A Caudle MR Svetlikova M | 2008 | Cell Cycle2008，7，22： | 1 |
| 17 | Oogenesis in cultures de- rived from adult human ovaries显示文摘 | Bukovsky A Svetlikova M Caudle MR | 2005 | Reprod Bid Endocrinol2005，3，： | 1 |
| 18 | Origin of germ cells and formation of new primary follicles in adult human ovaries 显示文摘 | Bukovsky A Caudle M R Svetlikova M | 2004 | Reprod Biol Endocrinol2004，2，： | 1 |
| 19 | Oogenesis in cultures derived from adult human ovaries显示文摘 | Bukovsky A Svetlikova M Caudle MR | 2005 | Reprod Biol Endocrinol2005，3，： | 1 |
| 20 | Immune physiology in tissue regeneration and aging,tumor growth,and regenerative medicine显示文摘 | Bukovsky A Caudle MR Carson RJ | 2009 | Aging2009，1，2： | 1 |
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