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| 1 | Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review显示文摘Chronic atrophic autoimmune gastritis(CAAG) is an organ-specific autoimmune disease characterized by an immune response, which is directed towards the parietal cells and intrinsic factor of the gastric body and fundus and leads to hypochlorhydria, hypergastrinemia and inadequate production of the intrinsic factor. As a result, the stomach's secretion of essential substances, such as hydrochloric acid and intrinsic factor, is reduced, leading to digestive impairments. The most common is vitamin B12 deficiency, which results in a megaloblastic anemia and iron malabsorption, leading to iron deficiency anemia. However, in the last years the deficiency of several other vitamins and micronutrients, such as vitamin C, vitamin D, folic acid and calcium, has been increasingly described in patients with CAAG. In addition the occurrence of multiple vitamin deficiencies may lead to severe hematological, neurological and skeletal manifestations in CAAG patients and highlights the importance of an integrated evaluation of these patients. Nevertheless, the nutritional deficiencies in CAAG are largely understudied. We have investigated the frequency and associated features of nutritional deficiencies in CAAG in order to focus on any deficit that may be clinically significant, but relatively easy to correct. This descriptive review updates and summarizes the literature on different nutrient deficiencies in CAAG in order to optimize the treatment and the follow-up of patients affected with CAAG. | Federica Cavalcoli Alessandra Zilli Dario Conte Sara Massironi | 2017 | World Journal of Gastroenterology2017，23，4： | 16 |
| 2 | Ultrasound elastographic techniques in focal liver lesions显示文摘Elastographic techniques are new ultrasound-based imaging techniques developed to estimate tissue deformability/stiffness. Several ultrasound elastographic approaches have been developed, such as static elastography, transient elastography and acoustic radiation force imaging methods, which include point shear wave and shear wave imaging elastography. The application of these methods in clinical practice aims at estimating the mechanical tissues properties. One of the main settings for the application of these tools has been liver stiffness assessment in chronic liver disease, which has been studied mainly using transient elastography. Another field of application for these techniques is the assessment of focal lesions, detected by ultrasound in organs such as pancreas, prostate, breast, thyroid, lymph nodes. Considering the frequency and importance of the detection of focal liver lesions through routine ultrasound, some studies have also aimed to assess the role that elestography can play in studying the stiffness of different types of liver lesions, in order to predict their nature and thus offer valuable non-invasive methods for the diagnosis of liver masses. | Clara Benedetta Conti Federica Cavalcoli Mirella Fraquelli Dario Conte Sara Massironi | 2016 | World Journal of Gastroenterology2016，22，9： | 6 |
| 3 | Rectal neuroendocrine tumors:Current advances in management,treatment,and surveillance显示文摘Rectal neuroendocrine neoplasms(r-NENs)are considered among the most frequent digestive NENs,together with small bowel NENs.Their incidence has increased over the past few years,and this is probably due to the widespread use of endoscopic screening for colorectal cancer and the advanced endoscopic procedures available nowadays.According to the current European Neuroendocrine Tumor Society(ENETS)guidelines,well-differentiated r-NENs smaller than 10 mm should be endoscopically removed in view of their low risk of local and distant invasion.R-NENs larger than 20 mm are candidates for surgical resection because of their high risk of distant spreading and the involvement of the muscularis propria.There is an area of uncertainty regarding tumors between 10 and 20 mm,in which the metastatic risk is intermediate and the endoscopic treatment can be challenging.Once removed,the indications for surveillance are scarce and poorly codified by international guidelines,therefore in this paper,a possible algorithm is proposed. | Camilla Gallo Roberta Elisa Rossi Federica Cavalcoli Federico Barbaro Ivo Boškoski Pietro Invernizzi Sara Massironi | 2022 | World Journal of Gastroenterology2022，28，11： | 4 |
| 4 | Nutritional deficiencies in inflammatory bowel disease: therapeutic approaches显示文摘 | Massironi S Rossi RE Cavalcoli FA | 2013 | Clin Nutr2013，32，6： | 1 |
| 5 | Current status and future perspectives for sequencing livestock genomes显示文摘Only in recent years, the draft sequences for several agricultural animals have been assembled. Assembling an individual animal's entire genome sequence or specific region(s) of interest is increasingly important for agricultural researchers to perform genetic comparisons between animals with different performance. We review the current status for several sequenced agricultural species and suggest that next generation sequencing (NGS) technology with decreased sequencing cost and increased speed of sequencing can benefit agricultural researchers. By taking advantage of advanced NGS technologies, genes and chromosomal regions that are more labile to the influence of environmental factors could be pinpointed. A more long term goal would be addressing the question of how animals respond at the molecular and cellular levels to different environmental models (e.g. nutrition). Upon revealing important genes and gene-environment interactions, the rate of genetic improvement can also be accelerated. It is clear that NGS technologies will be able to assist animal scientists to efficiently raise animals and to better prevent infectious diseases so that overall costs of animal production can be decreased. | Yongsheng Bai Maureen Sartor James Cavalcoli | 2012 | Journal of Animal Science and Biotechnology2012，3，1： | 1 |
| 6 | Scanning Kelvin probe and surface photovohage analysis of muhic- rystalline silicon显示文摘 | Castaldini A Cavalcoli D Cavallini A | 2002 | Materials Science and Engineering2002，9192，： | 1 |
| 7 | Regulation of the human endogenous retrovirus K (HML- 2) transcriptome by the HIV-1 Tat protein显示文摘 | Gonzalez-Hernandez M J Cavalcoli J D Sartor M A | 2014 | J Virol2014，88，16： | 1 |
| 8 | Gastro‐esophageal reflux and antisecretory drugs use among patients with chronic autoimmune atrophic gastritis: a study with pH‐impedance monitoring显示文摘 | A. Tenca S. Massironi D. Pugliese D. Consonni A. Mauro F. Cavalcoli M. Franchina M. Spampatti D. Conte R. Penagini | 2016 | Neurogastroenterol. Motil2016，，2： | 1 |
| 9 | Genomic and proteomic databases,large-scale analysis and integration of data 显示文摘 | Cavalcoli J D | 2001 | Trands Cardiovas Med2001，11，： | 1 |
| 10 | Defect Analysis of Hydrogenated Nanoerystalline Si Thin Films 显示文摘 | Cavallini A Cavalcoli D Rossi M | 2007 | Physica B2007，，401402： | 1 |
| 11 | Nutritional deficiencies in inflammatory bowel disease:therapeutic approaches显示文摘 | Massironi S Rossi RE Cavalcoli FA | 2013 | Clin Nutr2013，32，6： | 1 |
| 12 | Nutritional deficiencies in inflammatory bowel disease: therapeutic approaches显示文摘 | Massironi S Rossi RE Cavalcoli FA | 2013 | Clin Nutr2013，32，6： | 1 |
| 13 | Decade-long bacterial community dynamics in cystic fibrosis airways 显示文摘 | Zhao J Schloss PD Kalikin LM Carmody LA Foster BK Petrosino JF Cavalcoli JD Vandevanter DR Murray S Li JZ Young VB Lipuma JJ | 2012 | Proc Natl Acad Sci USA2012，109，15： | 1 |
| 14 | Surface photovoltage analysis of crystalline silicon for photovoltaic applications显示文摘 | CASTALDINI A CAVALCOLI D | 2002 | Sol Ene Mat & Sol Cel2002，72，1： | 1 |
| 15 | Overlap of genetic influences in phenotypes classically categorized as psychiatric vs medical disorders显示文摘Psychiatric disorders have traditionally been segregated from medical disorders in terms of drugs,treatment,insurance coverage and training of clinicians.This segregation is consistent with the long-standing observation that there are inherent differences between psychiatric disorders(diseases relating to thoughts,feelings and behavior)and medical disorders(diseases relating to physical processes).However,these differences are growing less distinct as we improve our understanding of the roles of epistasis and pleiotropy in medical genetics.Both psychiatric and medical disorders are predisposed in part by genetic variation,and psychiatric disorders tend to be comorbid with medical disorders.One hypothesis on this interaction posits that certain combinations of genetic variants(epistasis)influence psychiatric disorders due to their impact on the brain,but the associated genes are also expressed in other tissues so the same groups of variants influence medical disorders(pleiotropy).The observation that psychiatric and medical disorders may interact is not novel.Equally,both epistasis and pleiotropy are fundamental concepts in medical genetics.However,we are just beginning to understand how genetic variation can influence both psychiatric and medical disorders.In our recent work,we have discovered gene networks significantly associated with psychiatric and substance use disorders.Invariably,these networks are also significantly associated with medical disorders.Recognizing how genetic variation can influence both psychiatric and medical disorders will help us to understand the etiology of the individual and comorbid disease phenotypes,predict and minimize side effects in drug and other treatments,and help to reduce stigma associated with psychiatric disorders. | Richard C McEachin James D Cavalcoli | 2011 | World Journal of Medical Genetics2011，1，1： | 0 |
| 16 | Is there still a role for the hepatic locoregional treatment of metastatic neuroendocrine tumors in the era of systemic targeted therapies?显示文摘Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs) frequently present with distant metastases at the time of diagnosis and the liver is the most frequent site of spreading. The early identification of metastatic disease represents a major prognostic factor for GEP-NENs patients. Radical surgical resection, which is feasible for a minority of patients, is considered the only curative option, while the best management for patients with unresectable liver metastases is still being debated. In the last few years, a number of locoregional and systemic treatments has become available for GEP-NEN patients metastatic to the liver. However, to date only a few prospective studies have compared those therapies and the optimal management option is based on clinical judgement. Additionally, locoregional treatments appear feasible and safe for disease control for patients with limited liver involvement and effective in symptoms control for patients with diffuse liver metastases. Considering the lack of randomized controlled trials comparing the locoregional treatments of liver metastatic NEN patients, clinical judgment remains key to set the most appropriate therapeutic pathway. Prospective data may ultimately lead to more personalized and optimized treatments. The present review analyzes all the locoregional therapy modalities(i.e., surgery, ablative treatments and transarterial approach) and aims to provide clinicians with a useful algorithm to best treat GEP-NEN patients metastatic to the liver. | Federica Cavalcoli Emanuele Rausa Dario Conte Antonio Federico Nicolini Sara Massironi | 2017 | World Journal of Gastroenterology2017，23，15： | 0 |
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