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| 1 | Treatment with NADPH oxidase inhibitor apocynin alleviates diabetic neuropathic pain in rats显示文摘Increased reactive oxygen species by the activation of NADPH oxidase(NOX) contributes to the development of diabetic complications.Apocynin,a NOX inhibitor,increases sciatic nerve conductance and blood flow in diabetic rats.We investigated potential protective effect of apocynin in rat diabetic neuropathy and its precise mechanism of action at molecular level.Rat models of streptozotocin-induced diabetes were treated with apocynin(30 and 100 mg/kg per day,intragastrically) for 4 weeks.Mechanical hyperalgesia and allodynia were determined weekly using analgesimeter and dynamic plantar aesthesiometer.Western blot analysis and histochemistry/immunohistochemistry were performed in the lumbar spinal cord and sciatic nerve respectively.Streptozotocin injection reduced pain threshold in analgesimeter,but not in aesthesiometer.Apocynin treatment increased pain threshold dose-dependently.Western blot analysis showed an increase in catalase and NOX-p47 phox protein expression in the spinal cord.However,protein expressions of neuronal and inducible nitric oxide synthase(n NOS,i NOS),superoxide dismutase,glutathion peroxidase,nitrotyrosine,tumor necrosis factor-α,interleukin-6,interleukin-1β,aldose reductase,cyclooxygenase-2 or MAC-1(marker for increased microgliosis) in the spinal cord remained unchanged.Western blot analysis results also demonstrated that apocynin decreased NOX-p47 phox expression at both doses and catalase expression at 100 mg/kg per day.Histochemistry of diabetic sciatic nerve revealed marked degeneration.n NOS and i NOS immunoreactivities were increased,while S-100 immunoreactivity(Schwann cell marker) was decreased in sciatic nerve.Apocynin treatment reversed these changes dose-dependently.In conclusion,decreased pain threshold of diabetic rats was accompanied by increased NOX and catalase expression in the spinal cord and increased degeneration in the sciatic nerve characterized by increased NOS expression and Schwann cell loss.Apocynin treatment attenuates neuropathic pain by decelerating the increased oxidative stress-mediated pathogenesis in diabetic rats. | Murat Olukman Aytül onal Fatma Gül celenk Yigit Uyankgil Türker cavusoglu Neslihan Düzenli Sibel ülker | 2018 | Neural Regeneration Research2018，13，9： | 4 |
| 2 | Cigarette smoking increases plasma concentrations of vascular cell adhesion molecule-1in patients with coronary artery disease显示文摘 | CAVUSOGLU Y TIMURALP B US T | 2004 | Angiology2004，55，： | 1 |
| 3 | Midterm outcome after unilateral approach for bilateral decompression of lumbar spinal stenosis:5-year prospective study显示文摘 | Cavusoglu H Kaya R A Türkmenoglu O N Tuncer C Colak I Aydin Y | 2007 | Eur Spine J2007，16，： | 1 |
| 4 | Cigarette smoking increases plasma concentrations of vascular cell adhesion molecule-1in patients with coronary artery disease显示文摘 | CAVUSOGLU Y TIMURALP B US T | 2004 | Angiology2004，55，4： | 1 |
| 5 | Is magnetic resonance imaging reliable for the evaluation of the ruptured or healed anterior cruciate ligament?显示文摘 | Atik OS Cavusoglu AT Ayanoglu T | 2015 | Eklem Hastalik Cer- rahisi2015，26，1： | 1 |
| 6 | Treatment of intertrochanteric fractures by external fixation显示文摘 | Eksioglu F Gudemez T Cavusoglu T | 2000 | Bull Hosp Jt Dis2000，59，3： | 1 |
| 7 | Impact of gender on in-hospital percutaneous coronary interventional outcomes in African-Americans 显示文摘 | POLUDASU S CAVUSOGLU E CLARK L T | 2007 | J Invasive Cardiol2007，19，： | 1 |
| 8 | Cigarette smoking increases plasma concentrations of vascular cell adhesion molecule-1 in patients with coronary artery disease显示文摘 | Cavusoglu Y Timuralp B Us T | 2004 | Angiology2004，55，4： | 1 |
| 9 | Elastofibroma dorsa显示文摘 | Yavuzer R Ozmen S Cavusoglu T | | 0，，03： | 1 |
| 10 | Pin Site Care during Circular External Fixation Using Two Different Protocols显示文摘 | Cavusoglu A T Er M S Inal S | 2009 | J Orthop Trauma2009，23，10： | 1 |
| 11 | Cigarette smoking increases plasma concentrations of vascular cell adhesion molecule-1 in patients with coronary artery disease 显示文摘 | Cavusoglu Y Timuralp B Us T | 2004 | Angiology2004，55，4： | 1 |
| 12 | Cigarette smoking increases plasma concentrations of vascular cell adhesion molecule-1 in patients with coronary artery disease显示文摘 | Cavusoglu Y Timuralp B Us T | 2004 | Angiology2004，55，4： | 1 |
| 13 | Cigarette smoking increases plasma concentrations of vascular cell adhesion molecule-1 in patients with coronary artery disease显示文摘 | CAVUSOGLU Y TIMURALP B US T | 2004 | Angiology2004，55，4： | 1 |
| 14 | Cigarette smoking increases plasma concentrations of vascular cell adhesion molecule-1 in patients with coronary artery diseases 显示文摘 | Cavusoglu Y Timuralp B Us T | 2004 | Angiology2004，55，4： | 1 |
| 15 | A long-term follow-up study of anterior tibial allografting and instrumentation in the management of thoracolumbar tuberculous spondylitis显示文摘 | Cavusoglu H Kaya RA Türkmenoglu ON | 2008 | J Neurosurg Spine2008，8，1： | 1 |
| 16 | Elastofibroma dorsa显示文摘 | Yavuzer R Ozmen S Cavusoglu T | 2000 | Ann Plas Surg2000，45，3： | 1 |
| 17 | Difficulties and barriers for the implementing of HACCP and food safety systems in food businesses in Turkey显示文摘 | BAS M YUKSEL M CAVUSOGLU T | 2007 | Food Control2007，18，2： | 1 |
| 18 | Cigarette smoking increases plasma concentrations of vascular cell adhesion molecule-1 in patients with coronary artery disease显示文摘 | Cavusoglu Y Timuralp B Us T | 2004 | Angiology2004，55，4： | 1 |
| 19 | Treatment of intertrochanteric fractures by external fixation显示文摘 | Eksioglu F Gudemez E Cavusoglu T | 2000 | Bull Hosp Jt Dis2000，59，3： | 1 |
| 20 | The useof a low-profile Ilizarov external fixator in the treatmentof complex fractures and non-unions of the distal femur显示文摘 | Cavusoglu A T Ozsoy M H Dincel V E | 2009 | Acta OrthopBelg2009，75，2： | 1 |
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