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| 1 | Neuroprotective effect of edaravone in experimental glaucoma model in rats: a immunofluorescence and biochemical analysis显示文摘AIM: To evaluate the neuroprotective activity of systemically administered edaravone in early and late stage of experimental glaucoma in rats.METHODS: In this study, 60 Wistar albino rats were used. Experimental glaucoma model was created by injecting hyaluronic acid to the anterior chamber once a week for 6wk in 46 of 60 subjects. Fourteen subjects without any medication were included as control group.Edaravone administered intraperitoneally 3 mg/kg/d to the 15 of 30 subjects starting at the onset of glaucoma induction and also administered intraperitoneally3 mg/kg/d to the other 15 subjects starting at three weeks after the onset of glaucoma induction. The other16 subjects who underwent glaucoma induction was administered any therapy. Retinal ganglion cells(RGCs)have been marked with dextran tetramethylrhodamine(DTMR) retrograde at the end of the sixth week and after48 h, subjects were sacrificed by the method of cardiac perfusion. Alive RGC density was assessed in the wholemount retina. Whole-mount retinal tissues homogenized and nitric oxide(NO), malondialdehyde(MDA) and total antioxidant capacity(TAC) values were measured biochemically.RESULTS: RGCs counted with Image-Pro Plus program, in the treatment group were found to be statistically significantly protected, compared to the glaucoma group(Bonferroni,P <0.05). The neuroprotective activity of edaravone was found to be more influential byadministration at the start of the glaucoma process.Statistically significant lower NO levels were determined in the glaucoma group comparing treatment groups(Bonferroni, P <0.05). MDA levels were found to be highest in untreated glaucoma group, TAC levels were found to be lower in the glaucoma induction groups than the control group(Bonferroni, P <0.05).CONCLUSION: Systemic administration of edaravone in experimental glaucoma showed potent neuroprotective activity. The role of oxidative stress causing RGC damage in glaucoma was supported by this study results. | Arzu Toruk Aksar Nursen Yuksel Mustafa Gok Mustafa Cekmen Yusuf Caglar | 2015 | International Journal of Ophthalmology(English edition)2015，8，2： | 2 |
| 2 | Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF-kappaB pathways 显示文摘 | Ozbek E Cekmen M Ilbey Y O | 2009 | Ren Fail2009，31，5： | 1 |
| 3 | Effects of 1-name and timolol on aqueous IL-1 β,IL-6,IL-8,TNF-α and NO levels after Nd:YAG laser iridotomy in rabbits显示文摘 | Er H Doganay S Evereklioglu C Cekmen M Daglioglu MC Isci N | 2002 | Eur J Ophthalmol2002，12，4： | 1 |
| 4 | Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p58-MAPK and NF-kappa B pathways显示文摘 | Ozbek E Cekmen M Ilbey Y O | 2009 | Renal Failure2009，31，5： | 1 |
| 5 | Adrenomedullin and nitrite levels in children with dilated cardiomyopathy 显示文摘 | Kilinc M Balat A Cekmen M | 2003 | Pediatr Cardiol2003，24，： | 1 |
| 6 | Plasma lipid and lipoprotein concentrations in pregnancy induced hypertension显示文摘 | Cekmen MB Erbagci AB Bala A | 2003 | Clin Biochem2003，36，7： | 1 |
| 7 | The role of tissue reperfusinon in the reexpansion injury of the lungs显示文摘 | SIVRIKOZ M C TUNZGR B CEKMEN M | 2002 | Eur J Cardionthorac Surg2002，22，5： | 1 |
| 8 | Curcumin prevents oxi- dative renal damage induced by acetaminophen in rats显示文摘 | Cekmen M Ilbey YO Ozbek E | 2009 | Food Chem Toxicol2009，47，7： | 1 |
| 9 | Vascular endothelial growth factor levels are increased and associated with disease activity in patients with Behcet's syndrome 显示文摘 | Cekmen M Evereklioglu C Er H | 2003 | Int J Dermatol2003，42，11： | 1 |
| 10 | Comparison of antioxidant enzyme activity in the internal spermatic vein and brachial veins of patients with infertile varicocele显示文摘 | Ozbek E Cekmen M Simsek A | | 0，，03： | 1 |
| 11 | Urgent hyperbaric oxygen therapy (HBO2) for acute carbon monoxide poisoning显示文摘 | Cekmen N Erdemli O | 2009 | Bratisl Lek Listy2009，110，11： | 1 |
| 12 | Plasma lipid and lipo- protein concentrations in pregnancy induced hypertcnsion显示文摘 | Cekmen MB Erbagci AB Balat A | 2003 | Clin Biochem2003，36，3： | 1 |
| 13 | Decreased adrenomedullin and total nitrite levels in breast milk of preeclamptic women显示文摘 | Balat A Balat O | 2004 | Clin Biachem2004，37，2： | 1 |
| 14 | Nitric oxide and lipid peroxidation are increased and associated with decreased antioxidant enzyme activities in patients with age-related macular degeneration显示文摘 | Evereklioglu C Er H Donganary S Cekmen M | 2003 | Doc Ophthalmol2003，106，2： | 1 |
| 15 | Atorvastatin pre- vents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF-B pathways 显示文摘 | Ozbek E Cekmen M Ilbey YO | 2009 | Ren Fail2009，31，5： | 1 |
| 16 | The role of tissue reperfusion in the re-expansion injury of the lungs显示文摘 | Sivrikoz MC Tuncozgur B Cekmen M | 2002 | Eur J Cardiothorac Surg2002，22，5： | 1 |
| 17 | Atorvastatin prevents gentamicin-induced renal damage in rats through the inhibition of p38-MAPK and NF-kappaB pathways显示文摘 | Ozbek E Cekmen M Ilbey YO Simsek A Polat EC Somay A | | 0，，05： | 1 |
| 18 | Plasma lipid and lipoprotein concentration in pregnancy induced hypertension 显示文摘 | Cekmen MB Erbagic AB Balat A | 2003 | Clin Biochem2003，36，7： | 1 |
| 19 | Protective effect of montelukast which is cysteinyl-leukotriene receptor antagonist on gentamicin-induced nephrotoxicity and oxidative damage in rat kidney显示文摘 | Otunctemur A Ozbek E Cekmen M | 2013 | Ren Fail2013，35，3： | 1 |
| 20 | The role of tissue reperfusion in the reexpansion injury of the lungs显示文摘 | Sivrikoz MC Tuncozgour B Cekmen M | 2002 | Eur J Cardiothorac Surg2002，22，： | 1 |
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