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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | A model for the self- pulsing regime of microhollow cathode discharges显示文摘 | Chabert P Lazzaroni C Rousseau A | 2010 | Journal of Applied Physics2010，108，11： | 1 |
| 3 | Pleiotropy of insecticide resistance in the codling moth, Cydia pomonella 显示文摘 | Boivin T Chabert d' Hieres C Bouvier J C | 2001 | Entomologia Experimentalis et Applicata2001，99，： | 1 |
| 4 | From polymer chemistry to membrane elaboration: A global approach of fuel cell polymeric electrolytes显示文摘 | Iojoiu C Chabert F Mar6chal M | 2006 | Journal of Power Sources2006，153，2： | 1 |
| 5 | A chemical proteomics approach to phosphatidylinositol 3 - kinase signaling in macrophages 显示文摘 | Pasquali C Bertschy -Meier D Chabert C | 2007 | Mol Cell Proteomics2007，6，11： | 1 |
| 6 | Form polymer chemistry to membrane elaboration:A global approach of fuel cell polymeric electrolytes显示文摘 | Lojoin C Chabert F Marechal M | 2006 | J Power Sources2006，153，2： | 1 |
| 7 | An evaluation of stresses and deflection of spur gear teeth under strain显示文摘 | Chabert C Dang Tran T Mathis R | 1974 | ASME Journal of Engineering for Industry1974，，： | 1 |
| 8 | The Electronic Schoolbag, a CSCW workspace: presentation and evaluation显示文摘 | Chabert G Marty J C Caron B | 2006 | AI & SOCIETY2006，20，3： | 1 |
| 9 | A chemical proteomics approach to phosphatidylinositol 3-kinase signaling in macrophages显示文摘 | Pasquali C Bertschy-Meier D Chabert C | | 0，，11： | 1 |
| 10 | Preliminary results ofrobot-assisted laparoscopic radical prostatectomy ( RALP) afterfellowship training and experience in laparoscopic radicalprostatectomy ( LRP) 显示文摘 | Wolanski P Chabert C Jones L | 2012 | BJU Int2012，110，： | 1 |
| 11 | Form polymer chemistry to membrane elaboration:A global approach of fuel cell polymeric electrolytes显示文摘 | Lojoin C Chabert F Marechal M | 2006 | J Power Sources2006，153，2： | 1 |
| 12 | Prostate cancer detection in men with an initial diagnosis of atypical small acinar proliferation 显示文摘 | Mancuso P A Chabert C Chin P | 2007 | BJU Int2007，99，1： | 1 |
| 13 | A global model of the self-pulsing regime of micro-hollow cathode discharges显示文摘 | Lazzaronia C Chabert P | 2012 | Journal of Applied Physics2012，111，05： | 1 |
| 14 | Mouse liver paraoxonase-1 gene expression is downregulated in hyperhomocysteinemia显示文摘 | Janel N Robert K Chabert C | 2004 | Thromb Haemost2004，92，1： | 1 |
| 15 | Electrical characteristics of micro-hollow cathode discharges显示文摘 | Lazzaroni C Chabert P | 2013 | Journal of Physics D: Applied Physics2013，46，45： | 1 |
| 16 | The excitation struc- ture in a micro-hollow cathode discharge in the normal regime at medium argon pressure显示文摘 | Lazzaroni C Chabert P Rousseau | 2010 | Journal of Physics D: Applied Phys- ics2010，43，12： | 1 |
| 17 | PrPSc accumulation in placentas of ewes exposed to natural scrapie:influence of foetal genotype and effect on ewe-to-ewe lamb transmission显示文摘 | Andreoletti O Lacroux C Chabert A | 2002 | J Gen Virol2002，83，： | 1 |
| 18 | A global model of micro-hollow cath- ode discharges in the stationary regime显示文摘 | Lazzaroni C Chabert P | 2011 | Journal of Physics D: Applied Physics2011，44，44： | 1 |
| 19 | The electronic schoolbag,a CSCW workspace:presentation and evaluation显示文摘 | Chabert G Marty J C Caron B | | 0，，03： | 1 |
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