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| 1 | 北京PM_(2.5)化学物种的质量平衡特征显示文摘以北京 2个采样点连续采集的样品对PM2 5中的元素、水溶性离子和含碳组分进行分析 .车公庄和清华园PM2 5中有机物的含量分别为 2 7 8%和 30 9% ,是含量最丰富的物种 ,其次是二次无机粒子、土壤尘、元素碳和微量元素 .PM2 5中约有 2 4 %的质量未能鉴别成分 ,相关性分析表明 ,含碳物种的估算所引起的偏差可能是主要的原因 .采暖期重污染周和春季沙尘周PM2 5的化学物种构成悬殊 ,反映了季节性变化的源排放和特殊气象条件的综合作用 . | 杨复沫 贺克斌 马永亮 张强 Cadle S H Chan T Mulawa P A | 2004 | 环境化学2004，23，3： | 63 |
| 2 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 3 | Inflammatory bowel disease in Asia: A systematic review显示文摘 | Lani Prideaux Michael A Kamm Peter P De Cruz Francis K L Chan Siew C Ng | 2012 | Journal of Gastroenterology and Hepatology2012，，8： | 5 |
| 4 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 5 | High-order total variation-based image restoration 显示文摘 | Chan T Marquina A Mulet P | 2000 | SIAM Journal on Scientific Computing2000，22，2： | 1 |
| 6 | Framework of Success Criteria for Design Build Projects 显示文摘 | A P C Chan D Scott E W M Lam | 2002 | Journal of Management in Engineering2002，18，3： | 1 |
| 7 | Comparison of the stimulatory sffects of ovine,porcine and human follicle-stimulating hormone and of ovine and human luteinizing hormone on the accumulation of cyclic AMP by porcine granulosa cells显示文摘 | Lindsay A M Channing C P | 1979 | Journal of Endocrinology1979，80，： | 1 |
| 8 | A prospective randomized study of chemotherapy adjunctive to definitive radiotherapy in advanced nasopharyngeal carcinoma显示文摘 | Chan A T Teo P M Leung T W | 1995 | Int J Radiat Oncol Biol Phys1995，33，3： | 1 |
| 9 | Supervised learning of semantic classes for image annotation and retrieval 显示文摘 | Carneiro G Chan A B Moreno P J | 2007 | IEEE Transactions on Pattern Analysis and Machine Intelligence2007，29，3： | 1 |
| 10 | A PhysiologicallyBased Pharmacokinetic Model for Endosulfan in the MaleSprague-Dawley Rats显示文摘 | Chan M P Morisawa S Nakayama A | 2006 | Environmental Toxicology2006，21，5： | 1 |
| 11 | Temporal and spatial trends of mercury in fish collected in the English-Wabigoon river system in Ontario, Canada显示文摘 | Kinghorn A Solomon P Chan H M | 2007 | Science of the Total Environment2007，372，2： | 1 |
| 12 | Safety and tolerabilityof combination antiretroviral post-exposure prophylaxisin a population-based setting显示文摘 | Braitstein P Chan K Beardsell A | 2002 | Acquirlmmune DeficSyndr2002，29，5： | 1 |
| 13 | Early and sustained survival benefit associated with statin therapy at the time of percutaneous coronary intervention显示文摘 | Chan A W Bhatt D L Chew D P | | 0，，： | 1 |
| 14 | Fracture Energy of Weakly Reinforced Concrete Beams显示文摘 | Azad A Mirza M Chan P | | 0，，01： | 1 |
| 15 | PPAR agonists modulate human osteoclast formation and activity in vitro显示文摘 | Chan BY Gartland A Wilson P J | 2007 | Bone2007，40，： | 1 |
| 16 | Temporal and spatial trends of mercury in fish collected in the English-Wabigoon river system in Ontario, Canada 显示文摘 | Kinghorn A Solomon P Chan H M | 2007 | Science of the Total Environment2007，372，23： | 1 |
| 17 | The rode of chemotherapy in the management of nasopharyngea carcinomal显示文摘 | Chan A T C Teo P M Leung T W | 1998 | Cancer1998，82，6： | 1 |
| 18 | Free radical pathways in CNS injury显示文摘 | LEWEN A MATZ P CHAN P H | 2000 | J Neurotrauma2000，17，10： | 1 |
| 19 | Impact of Caregiving on Health and Quality of Life : A Comparative Popu- lation-based Study of Caregivers for Elderly Persons and Noncaregivers 显示文摘 | Ho S C Chan A Woo J Chong P and Sham A | 2009 | Journals of Gerontology Series A: Biologi- cal Sciences and Medical Sciences2009，64，： | 1 |
| 20 | Food -derived peptidic antioxidants: A review of their production, assessment, and potential applications 显示文摘 | Samaranayaka A G P Li -Chan E C Y | 2011 | Journal of Functional Foods2011，3，4： | 1 |
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