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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome显示文摘Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiringventilatory support.We aimed to compare the efficacy of non-invasive ventilation against invasive mechanicalventilation treating respiratory failure in this disease.Methods Retrospective analysis was conducted on all respiratory failure patients identified from the HongKong Hospital Authority Severe Acute Respiratory Syndrome Database.Intubation rate, mortality and secondaryoutcome of a hospital utilizing non-invasive ventilation under standard infection control conditions ( NIVHospital) were compared against13 hospitals using solely invasive ventilation (IMVHospitals).Multiple logisticregression analyses with adjustments for confounding variables were performed to test for association betweenoutcomes and hospital groups.Results Both hospital groups had comparable demographics and clinical profiles, but NIV Hospital (42patients) had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid commencement.Compared to IMV Hospitals (451 patients), NIV Hospital had lower adjustedodds ratios for intubation (0.36, 95% CI 0.164 -0.791,P=0.011) and death (0.235, 95% CI 0.077 -0.716,P=0.011), and improved earlier after pulsed steroid rescue.There were no instances of transmission ofsevere acute respiratory syndrome among health care workers due to the use of non-invasive ventilation.Conclusion Compared to invasive mechanical ventilation, non-invasive ventilation as initial ventilatory supportfor acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated withreduced intubation need and mortality. | Loretta YC Yam Alfred YF Chan Thomas MT Cheung Eva LH Tsui Jane CK Chan Vivian CW Wong | 2005 | Chinese Medical Journal2005，，17： | 3 |
| 3 | Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides 显示文摘 | Bennett CF Chiang MY Chan H shoemaker JE Mirabelli CK | 1992 | Mol Pharmacol1992，41，6： | 1 |
| 4 | Continuous curvilinear capsulorhexis in intumescent or hypermature cataract with liquefied cortex 显示文摘 | Chan DD Ng AC Leung CK | 2003 | J Cataract Refract Surg2003，29，： | 1 |
| 5 | A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellularcarcinoma显示文摘 | Chan AO Yuen MF Hui CK | 2002 | Cancer2002，94，： | 1 |
| 6 | Cytotoxicity of triamcinolone on cultured human retinal pigment epithelial cells :comparison ith dexamethasone and hydrocortisone 显示文摘 | Yeung CK Chan KP Chan CK | 2004 | Jpn J Ophthalmol2004，48，3： | 1 |
| 7 | RF heating of implanted spinal fusion stimulator during magnetic resonance imaging显示文摘 | Chou CK Mcdougall JA Chan KW | 1997 | IEEE Trans Biomed Eng1997，44，5： | 1 |
| 8 | Roux-en-Y reconstruc-tion after distal gastrectomy to reduce enterogastric reflux and Helicobacter pylori infection 显示文摘 | Chan DC Fan YM Lin CK etal | 2007 | J GastrointestSurg2007，，12： | 1 |
| 9 | Phase lb randomized study of antidote- controlled modulation of factor IXa activity in patients with stable coronal3 artery disease 显示文摘 | Chan MY Cohen MG Dyke CK | 2008 | Circulation2008，117，22： | 1 |
| 10 | The efficacy,safety and dur ability of selective renal arte ial embolization in treating symptomatic and a symptomatic renal angiomyolipoma 显示文摘 | Chan CK Yu S Yip S | 2011 | Urology2011，77，3： | 1 |
| 11 | Recombinant human leptin in women with hypothalamic amenorrhea显示文摘 | Welt CK Chan JL Bullen J | 2004 | N Engl J Med2004，351，10： | 1 |
| 12 | Air pollution in mega cities in China显示文摘 | Chan CK Yao X | 2008 | Atmo Environ2008，42，： | 1 |
| 13 | Complete blood count refer- ence interval diagrams derived from NHANES III: stratification by age, sex, and race显示文摘 | Cheng CK Chan J Cembrowski GS | 2004 | Lab Hematol2004，10，： | 1 |
| 14 | The efficacy,safety and durability of selective renal arterial embolization in treating symptomatic and asymptomatic renal angiomyolipoma显示文摘 | Chan CK Yu S Yip S | 2011 | Urology2011，，03： | 1 |
| 15 | Surgi- cal morbidity and mortality in obturator hernia:A 10-year retrospective risk factor evaluation 显示文摘 | Chan KV Chan CK Yau KW et at | 2014 | Hernia2014，18，3： | 1 |
| 16 | Suicidality in Chinese adolescents in Hong Kong: the role of family and cultural influences显示文摘 | Chan WS Law CK Liu KY | 2009 | Soc Psychiatry Psychiatr Epidemiol2009，44，4： | 1 |
| 17 | Analysis of RNA-Seq data using top Hat and cufflinks显示文摘 | Ghosh S Chan CK | 2016 | Methods Mol Biol2016，1374，： | 1 |
| 18 | Femtosecond laser cataract surgery: technology and clinical practice显示文摘 | Timothy V Roberts Michael Lawless Colin CK Chan Mark Jacobs David Ng Shveta J Bali Chris Hodge Gerard Sutton | 2012 | Clinical & Experimental Ophthalmology2012，，2： | 1 |
| 19 | Phase lb random- ized study of antidote-controlled modulation of Factor Ⅸa activity in patients with stable coronary artery disease 显示文摘 | Chan MY Cohen MG Dyke CK | 2008 | Circulation2008，117，22： | 1 |
| 20 | Supramolocular structure and nuclear targeting efficiency determine the enhancement of trans- fection by modified polylysine显示文摘 | Chan CK Senden T Jans DA | 2000 | Gene therapy2000，7，19： | 1 |
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