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	题名	作者	年代	出处	被引量
1	Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease.	WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho	2012	Translational Neurodegeneration2012，1，1：	3
2	DJ - 1 could predict worse prognosis in esophageal squamous cell carcinoma 显示文摘	Yuen HF Chan YP Law S	2008	Cancer Epidemiol Biomarkers Prev2008，17，12：	1
3	Frequency and determinants of poststroke dementia in Chinese 显示文摘	Tang WW Chan SS Chui HF	2004	Stroke2004，35，4：	1
4	DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma显示文摘	Yuen HF Chan YP Law S	2008	Cancer Epidemiol Biomarkers Prey2008，17，12：	1
5	Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation显示文摘	Tse HF Kwong YL Chan JK		0，，9351：	1
6	Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cel implantation显示文摘	Tse HF Kwong YL Chan JK		0，，9351：	1
7	Angiogenesis in ischemic myocardium by intramyocardial autologous bone marrow mononuclear cell transplantation显示文摘	Tse HF Kwong YL Chan JK	2003	Lancet2003，361，：	1
8	Angiogenseis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation 显示文摘	Tse HF Kwong YL Chan JK	2003	Lancet2003，361，9351：	1
9	Angiogenesis in ischemic myocardium by intra myocardial autologous bone mononuclear cell transplantation显示文摘	Tse HF Kwong YL Chan JK	2003	Lancet2003，361，：	1
10	Angioogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell transplantation显示文摘	Tse HF Kwong YL Chan JK	2003	Lancet2003，361，9351：	1
11	Significance of Twist and E cad herin expression in the metastatic progression of prostatic cancer显示文摘	Yuen HF Chua CW Chan YP	2007	Histopathol2007，50，5：	1
12	显示文摘	Tse HF Kwong YL Chan JKF	2003	Lancet2003，361，：	1
13	Clinical and angiographic findings of complete atrioventricular block in acute inferior myocardial infarction显示文摘	Jim MH Chan AO Tse HF	2010	Ann Acad Med Singapore2010，39，3：	1
14	Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation显示文摘	Tse HF Kwong YL Chan JKF	2003	Lancet2003，361，：	1
15	Angiogenesis in ischemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation显示文摘	Tse HF Kwong YL Chan JK	2003	Lancet2003，361，9351：	1
16	Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation 显示文摘	Kwong YL Chan JK	2003	Lancet2003，361，9351：	1
17	Hemodynamics and wall mechanics in human carotid bifurcation and its consequences for atherogenesis:investigation of inter-individual variation显示文摘	Kaazempur-Mofrad MR Chan RC	2004	Biomech Model Mechanobiol2004，3，：	1
18	Late measures of mi- crostructural alterations in severe neonatal hypoxic-ische- mic encephalopathy by MR diffusion tensor imaging 显示文摘	Chan KG Khong PL Lau HF	2009	Int J Dev Neurosci2009，27，6：	1
19	Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation 显示文摘	Tse HF Kwong YL Chan J	2003	Lancet2003，361，：	1
20	Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation显示文摘	Tse HF Kwong YL Chan JK	2003	Lancet2003，361，9351：	1

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