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| 1 | Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome显示文摘Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiringventilatory support.We aimed to compare the efficacy of non-invasive ventilation against invasive mechanicalventilation treating respiratory failure in this disease.Methods Retrospective analysis was conducted on all respiratory failure patients identified from the HongKong Hospital Authority Severe Acute Respiratory Syndrome Database.Intubation rate, mortality and secondaryoutcome of a hospital utilizing non-invasive ventilation under standard infection control conditions ( NIVHospital) were compared against13 hospitals using solely invasive ventilation (IMVHospitals).Multiple logisticregression analyses with adjustments for confounding variables were performed to test for association betweenoutcomes and hospital groups.Results Both hospital groups had comparable demographics and clinical profiles, but NIV Hospital (42patients) had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid commencement.Compared to IMV Hospitals (451 patients), NIV Hospital had lower adjustedodds ratios for intubation (0.36, 95% CI 0.164 -0.791,P=0.011) and death (0.235, 95% CI 0.077 -0.716,P=0.011), and improved earlier after pulsed steroid rescue.There were no instances of transmission ofsevere acute respiratory syndrome among health care workers due to the use of non-invasive ventilation.Conclusion Compared to invasive mechanical ventilation, non-invasive ventilation as initial ventilatory supportfor acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated withreduced intubation need and mortality. | Loretta YC Yam Alfred YF Chan Thomas MT Cheung Eva LH Tsui Jane CK Chan Vivian CW Wong | 2005 | Chinese Medical Journal2005，，17： | 3 |
| 2 | Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation显示文摘 | Chan TA Wang Z Dang LH | 2002 | Proc Natl Acad Sci U S A2002，99，： | 1 |
| 3 | Endoscopicsubmucosal dissection for colonic lesions:why and how should we do it? 显示文摘 | Lai LH Chan FK | 2011 | J Dig Dis2011，12，4： | 1 |
| 4 | Hedgehog signaling induces osteosarcmna development through Yapl and H19 overexpression 显示文摘 | Chan LH Wang W Yeung W | 2014 | Oncogene2014，33，40： | 1 |
| 5 | Apoptotic effects of a high performance liquid chromatography (HPLC) fraction of Antrodia camphorata mycelia are mediated by down-regulation of the expressions of four tumor-related genes in human non-small cell lung carcinoma A549 cell显示文摘 | Chan YY Chang CS Chien LH | 2010 | J Ethnopharmacol2010，127，： | 1 |
| 6 | Comparison of autogenous and al ogenous posterior cruciate ligament reconstructions of the knee显示文摘 | Wang CJ Chan YS Weng LH | | 0，，12： | 1 |
| 7 | Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation 显示文摘 | Chan TA Wang Z Dang LH | 2002 | Proc Natl Acad Sci U S A2002，99，12： | 1 |
| 8 | Successful anesthetic management of a patient with thyroid carcinoma invading the trachea with tracheal obstruction, scheduled for total thyroidec- tomy 显示文摘 | Liou JY Chow LH Chan KH | 2014 | J Chin MedAssoc2014，77，9： | 1 |
| 9 | Hyperbaric oxygen for acute carbon mon- oxide poisoning显示文摘 | Weaver LH Hopkins RO Chan KJ | 2002 | N Engl J Meal2002，347，14： | 1 |
| 10 | Childhood injuries in Hong Kong:a one-year surveillance program at an accident and emergency department显示文摘 | Chow CB Chan KH Chiu LH | 1993 | Hong Kong Journal of Paediatrics1993，，： | 1 |
| 11 | Rapamycin together with herceptin significantly increased anti- tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells 显示文摘 | Wang LH Chan JL Li W | 2007 | Int J Cancer2007，121，1： | 1 |
| 12 | Effects of age of acquisition on brain activation during Chinese character recognition 显示文摘 | Weekes BS Chan Alice HD & Tan LH | 2008 | Neuropsychologia2008，46，： | 1 |
| 13 | Lost in transition-a review of qualitative literature of newly qualified Registered Nurses' experiences in their transition to practice journe显示文摘 | Teoh YT Pua LH Chan MF | 2013 | Nurse Educ Today2013，33，2： | 1 |
| 14 | A 10-year prospective audit of LASIK outcomes for myopia in 37,932 eyes at a single institution in Asia显示文摘 | Yuen LH Chan WK Koh J | 2010 | Ophthalmology2010，117，： | 1 |
| 15 | Effects of dl-3-nbutylphthalide on vasculardementiaandangiogenesis显示文摘 | Zhang LH LU LH Chan WM | 2012 | NeurochemRes2012，37，5： | 1 |
| 16 | China' s engagement with global health di- plomacy: was SARS a watershed? 显示文摘 | Chan LH Chen L Xu J | 2010 | PLoS Med2010，7，10： | 1 |
| 17 | Endoscopic submucosal dissection for colonic lesions:why and how should we do it显示文摘 | Lai LH Chan FK | | 0，，04： | 1 |
| 18 | Targeted inactivation of CTNNB1 reveals unexpected effects of β catenin mutation显示文摘 | Chan TA wang ZH Dang LH | 2002 | Proc Natl Acad Sci USA2002，99，12： | 1 |
| 19 | Lost in transition-a review of qualitative literature of newly qualified Registered Nurses' experiences in their transition to practice journey显示文摘 | Teoh YT Pua LH Chan MF | 2013 | Nurse Educ Today2013，33，2： | 1 |
| 20 | Heterology expression of the Arabidopsis Crepeat/dehydration response element binding Factor 1 gene confers elevated tolerance to chilling and oxidative stresses in transgenic tomato显示文摘 | HSIEH T H LEE J T YANG P T CHIU LH CHARNG Y Y WANG Y C CHAN M T | 2002 | Plant Physiology2002，129，： | 1 |
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