|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Statistical models for the prediction of respirable suspended particulate matter in urban cities 显示文摘 | GOYAL P CHAN A T JAISWAL N | 2006 | Atmos Environ2006，40，： | 1 |
| 3 | Inflammatory conditions of the male excurrent ductal system显示文摘 | Chan P T Schlegel P N | 2002 | Part I Journal of Andrology2002，23，： | 1 |
| 4 | Pilot study of lowdose ery-thromycin in bronchiectasis显示文摘 | Tsang K W T Ho P L Chan K N | 1999 | Eur J Respir1999，13，2： | 1 |
| 5 | Statistical models for the prediction of respirable suspended particulate matter in urban cities显示文摘 | Goyal P Chan A T Jaiswal N | 2006 | Atmospheric Environment2006，40，： | 1 |
| 6 | Optimal progressive censo-ring plans for the Weibull distribution显示文摘 | Ng H K T Chan P S Balakrishnan N | 2004 | American Statistical Association and the American Society for Quality Technometrics2004，46，4： | 1 |
| 7 | Optimal sample size allo-cation for tests with multiple levels of stress with extreme value regression显示文摘 | Ng H K T Balakrishnan N Chan P S | 2007 | Naval Research Logistics2007，54，： | 1 |
| 8 | Seasonal variation in respiratory syncytical virus chest infection in the tropics显示文摘 | Chan P W Chen F T Tan T N | 2002 | Pediatr Pulmonology2002，34，1： | 1 |
| 9 | A Temperature-compensated CMOS ring oscillator for power-management circuits显示文摘 | Leung K N Lo C H Mok P K T Mai T T Leung W Y and Chan M J | 2007 | Electronics Letters2007，43，15： | 1 |
| 10 | Estimation of parameters from progressively censored data using EM algorithm显示文摘 | Ng H K T CHAN P S Balakrishnan N | 2002 | Computational Statistics and Data Analysis2002，39，： | 1 |
| 11 | Measure- ment of pubertal status with a chinese self-report puber- tal development scale显示文摘 | Chan N P T Sung R Y T Nelson E A S | 2010 | Matern Child Health J2010，14，3： | 1 |
| 12 | Estimation of parameters from progressively censored data using EM algorithm显示文摘 | Ng H K T Chan P S Balakrishnan N | 2002 | Computational Statistics and Data Analysis2002，39，4： | 1 |
| 13 | Es- timation of parameters from progressively censored data using EM algorithm显示文摘 | NG H K T CHAN P S BALAKRISHNAN N | 2002 | Computational Statis- tics Data Analysis2002，39，4： | 1 |
| 14 | Optimal progressive censoring plans for the Weibull distribution显示文摘 | Ng H K T Chan P S Balakrishnan N | 2004 | Technometrics2004，46，4： | 1 |
| 15 | Manometry based randomised trial of endoscopic sphincterotomy for sphincter of Oddi dysfunction显示文摘 | Toouli J Roberts-Thomson I C Kellow J Dowsett J Saccone G T Evans P Jeans P Cox M Anderson P Worthley C Chan Y Shanks N Craig A | 2000 | Gut2000，4698，： | 1 |
| 16 | Distribution of adriamycin in cancer patients显示文摘 | Lee Y T N Chan K K Harris P A | 1980 | Cancer1980，45，： | 1 |
| 17 | Solving the motion plarming problem by using neural networks显示文摘 | Chan R H T Tam P K Leung D N K | 1994 | Robotica1994，12，4： | 1 |
| 18 | Phenolic compound formation from the low temperature pyrolysis of tobacco显示文摘 | MCGRATH T E BROWN A P MERUVA N K CHAN W G | 2009 | J Anal Appl Pyrolysis2009，84，2： | 1 |
| 19 | MRI of cochlear otosclerosis显示文摘 | Goh J P N Chan L L Tan T Y | | 0，，894： | 1 |
| 20 | Quantitative analy- sis of circulating tumor cells in peripheral blood of os- teosarcoma patients using osteoblast-specific messenger RNA markers :A pilot study显示文摘 | Wong I H N Chan A T Johnson P J | 2000 | Clinical Cancer Research2000，6，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员