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| 1 | Comparison study of phosphorus adsorption on different waste solids:Fly ash,red mud and ferric–alum water treatment residues显示文摘The adsorption of phosphorus(P) onto three industrial solid wastes(fly ash, red mud and ferric–alum water treatment residual(FAR)) and their modified materials was studied systematically via batch experiments. Compared with two natural adsorbents(zeolite and diatomite), three solid wastes possessed a higher adsorption capacity for P because of the higher Fe, Al and Ca contents. After modification(i.e., the fly ash and red mud modified by FeCl_3 and FARs modified by HCl), the adsorption capacity increased, especially for the modified red mud, where more Fe bonded P was observed. The P adsorption kinetics can be satisfactorily fitted using the pseudo-second-order model. The Langmuir model can describe well the P adsorption on all of the samples in our study. p H and dissolved organic matter(DOM) are two important factors for P adsorption. Under neutral conditions, the maximum adsorption amount on the modified materials was observed. With the deviation from pH 7, the adsorption amount decreased, which resulted from the change of P species in water and surface charges of the adsorbents. The DOM in water can promote P adsorption, which may be due to the promotion effects of humic-Fe(Al) complexes and the pH buffer function exceeds the depression of competitive adsorption. | Ying Wang Yange Yu Haiyan Li Chanchan Shen | 2016 | Journal of Environmental Sciences2016，28，12： | 10 |
| 2 | Accuracy Comparison of Gridded Historical Cultivated Land Data in Jiangsu and Anhui Provinces显示文摘The spatial resolution of source data, the impact factor selection on the grid model and the size of the grid might be the main limitations of global land datasets applied on a regional scale. Quantitative studies of the impacts of rasterization on data accuracy can help improve data resolution and regional data accuracy. Through a case study of cropland data for Jiangsu and Anhui provinces in China, this research compared data accuracy with different data sources, rasterization methods, and grid sizes. First, we investigated the influence of different data sources on gridded data accuracy. The temporal trends of the History Database of the Global Environment(HYDE), Chinese Historical Cropland Data(CHCD), and Suwan Cropland Data(SWCD) datasets were more similar. However, different spatial resolutions of cropland source data in the CHCD and SWCD datasets revealed an average difference of 16.61% when provincial and county data were downscaled to a 10 × 10 km^2 grid for comparison. Second, the influence of selection of the potential arable land reclamation rate and temperature factors, as well as the different processing methods for water factors, on accuracy of gridded datasets was investigated. Applying the reclamation rate of potential cropland to grid-processing increased the diversity of spatial distribution but resulted in only a slightly greater standard deviation, which increased by 4.05. Temperature factors only produced relative disparities within 10% and absolute disparities within 2 km^2 over more than 90% of grid cells. For the different processing methods for water factors, the HYDE dataset distributed 70% more cropland in grid cells along riverbanks, at the abandoned Yellow River Estuary(located in Binhai County, Yancheng City, Jiangsu Province), and around Hongze Lake, than did the SWCD dataset. Finally, we explored the influence of different grid sizes. Absolute accuracy disparities by unit area for the year 2000 were within 0.1 km^2 at a 1 km^2 grid size, a 25% improvement over the 10 km^2 grid size. Compared to the outcomes of other similar studies, this demonstrates that some model hypotheses and grid-processing methods in international land datasets are truly incongruent with actual land reclamation processes, at least in China. Combining the model-based methods with historical empirical data may be a better way to improve the accuracy of regional scale datasets. Exploring methods for the above aspects improved the accuracy of historical cropland gridded datasets for finer regional scales. | YUAN Cun YE Yu TANG Chanchan FANG Xiuqi | 2017 | Chinese Geographical Science2017，27，2： | 5 |
| 3 | siRNA-functionalized lanthanide nanoparticle enables efficient endosomal escape and cancer treatment显示文摘Attaching DNA/RNA to nanomaterials is the basis for nucleic acid-based assembly and drug delivery.Herein,we report that small interfering RNA(siRNA)effectively coordinates with ligand-free lanthanide nanoparticles(NaGdF4 NPs),and forms siRNA/NaGdF4 spherical nucleic acids(SNA).The coordination is primarily attributed to the interaction between Gd and phosphate backbone of the siRNA.Surprisingly,an efficient encapsulation and rapid endosomal escape of siRNA from the endosome/lysosome were achieved,due to its flexible ability to bound to phospholipid head of endosomal membrane,thereby disrupting the membrane structure.Resorting to the dual properties of NaGdF4 NPs,siRNA loading,and endosomal escape,siRNA targeting programmed cell death-ligand 1(siPD-L1)/NaGdF4 SNA triggers significant gene silencing in vitro and in vivo,and effectively represses the tumor growth in both CT26 tumor model and 4T1 orthotopic murine model. | Chanchan Yu Kun Li Lin Xu Bo Li Chunhui Li Shuai Guo Ziyue Li Yuquan Zhang Abid Hussain Hong Tan Mengyu Zhang Yongxiang Zhao Yuanyu Huang Xing-Jie Liang | 2022 | Nano Research2022，15，10： | 1 |
| 4 | The microgravity enhanced polymer-mediated siRNA gene silence by improving cellular uptake显示文摘Microgravity(MG)effect is a weightlessness phenomenon caused by the distance from the ground or low gravity of other planets outside the earth's atmosphere.The various effects of MG have been corroborated in human and animal studies and modeled in cell-based analogs.However,the impact of MG on siRNA performance remains to be elucidated,which is crucial for aerospace medicine.In this study,we prepared nucleic acid nanomicelles(EAASc/siRNA)by using tri-block copolymer of PEG45-PAMA40-P(C7A36-DBA37)(EAASc)and siRNA and explored its working mechanism under simulated microgravity(SMG)condition generated by a random positioning machine(RPM).The binding ability of EAASc to siRNA and silence activity were firstly confirmed in normal gravity(NG)environment.Evaluation of PLK1 mRNA expression revealed that gene inhibition efficiencies were increased by 28.7%(HepG2)and 28.9%(A549)under SMG condition,compared with those under NG condition.In addition,mechanism exploration indicated that morphology and migration capability of cancer cells were significantly changed,the internalization of EAASc/siRNA by cells was magnified when the cells were incubated with RPM.No significant difference was observed regarding the expression profiles of genes involved in RNA interference(RNAi)pathway,including Ago2,Dicer,TRBP,and so on.Taken together,siRNA activity was elevated under SMG condition owning to increased cellular internalization.This study,for the first time to our knowledge,provides valuable theory for development and application of siRNA therapeutic in space in the future. | Tongren Yang Chanchan Yu Changrong Wang Chunhui Li Mengjie Zhang Xiaofan Luo Yuhua Weng Anjie Dong Xiaoqiong Li Yulin Deng Yuanyu Huang | 2020 | Biophysics Reports2020，6，6： | 1 |
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