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| 1 | Update in management of mesenteric ischemia显示文摘肠系膜局部缺血混乱被剥夺一或几个腹的机关遇见新陈代谢的要求足够的呼吸的一个发行量不足事件猛抛。尽管 mes 伤寒局部缺血不经常发生,死亡率从 60% ~ 100% ,依靠阻塞的消息提供者。成功的结果依赖于怀疑和迅速的管理的一个高索引。我们简短考察病理生理学和演讲各种各样是化学家实体并且在诊断和治疗考察当前的现状。尽管有在诊断和治疗的进展,迅速的诊断和支持的照顾为成功的结果仍然保持批评。新成像技术,血管内治疗和新兴的研究可以改进我们的途径到这个致命的条件。 | Robert W Chang John B Chang Walter E Longo | 2006 | World Journal of Gastroenterology2006，12，20： | 38 |
| 2 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 3 | 基于Baveno Ⅵ标准和脾硬度在病毒学抑制的乙型肝炎肝硬化患者中排除高风险静脉曲张的研究显示文摘目前尚无数据可证实HBV相关肝硬化在病毒抑制的情况下,脾硬度在排除高风险静脉曲张方面的性能。因此,该研究旨在前瞻性地验证脾硬度(临界值46 kPa)结合Baveno VI标准在排除这些患者的高风险静脉曲张中的性能。 | WANG HY WEN B CHANG XY 王海玉 | 2021 | 临床肝胆病杂志2021，37，3： | 17 |
| 4 | 沪宁杭地区城市群发展规划探索显示文摘在全球经济一体化的背景下,世界经济中心是在一批具有重大影响的城市群区域。我国许多省市正在编制城市群规划,出现了城市群潮涌神州的新局面。然而城市群区的空间发展规划需要探索的问题不少。以沪宁杭地区为典型例证,就城市群规划的指导思想与总体思路、区域空间尺度的研究、各种要素的组合及其城市群规划深层发展等问题,进行初步的探索。在城市群区总体发展的关键要素整合方面提出了三个新观点:①城市发展与自然要素的整合;②重视区域交通要素的组织;③城市群区内经济要素流的合理化。以期引起对此问题的深入研究与实践总结。 | 姚士谋 陈彩虹 陈爽 William Y B Chang | 2005 | 长江流域资源与环境2005，14，3： | 13 |
| 5 | 胃肠道恶性神经外胚层肿瘤:19例临床病理、免疫组化和分子分析显示文摘胃肠道恶性神经外胚层肿瘤临床非常罕见,目前对其具体发病机制尚不清楚。该文旨在分析胃肠道恶性神经外胚层肿瘤的临床病理特征、治疗及预后。该文收集19例胃肠道恶性神经外胚层肿瘤患者,平均肿瘤直径为4.2 cm。肿瘤最常见的原发部位为小肠(57.9%),其次为胃(15.8%)、结肠(10.5%)、回盲部(5.3%)、食管下端(5.3%)和肛管(5.3%)。 | Chang B Yu L Guo W W 魏建国(摘译) 方三高(审校) | 2020 | 临床与实验病理学杂志2020，36，1： | 5 |
| 6 | 中国城市化发展速度界定的初步探索显示文摘纵观我国城市化发展历程,虽然取得了举世瞩目的成就,同时也带来了许多问题,具体表现为城市化快速扩张过程中带来的资源与生态环境压力。阐述了城市化发展的国内外背景,认为城市化过程中的土地资源、水资源、环境容量等是影响城镇健康可持续发展的重要因素,构成了制约城市发展的综合性支撑体系。对我国城市化道路健康发展的基本策略进行了阐述。在对我国城市化发展速度的主要影响因素进行分析的基础上,根据人均GDP增长和各地区城市发展条件与潜力,通过综合指标分析,对我国不同类型区的城市化发展速度进行了初步界定及趋势分析。 | 吴建楠 姚士谋 朱天明 William Y B Chang | 2010 | 长江流域资源与环境2010，19，5： | 4 |
| 7 | A new true triaxial cell for testing mechanical properties of rock, and its use to determine rock strength and deformability of Westerly granite显示文摘 | B Haimson C Chang | 2000 | International Journal of Rock Mechanics and Mining Sciences2000，，1： | 4 |
| 8 | HETEROPHYLLIN-A AND B,TWO CYCLOPEPTIDES,FROM THE ROOTS OF PSEUDOSTELLARIA HETEROPHYLLA显示文摘Two cyclopeptides,heterophyllin A and B,have been isolated from the rootsof Pseudostellaria heterophylla.Their structures were elucidated by chemical,spectroscopic,and enzymatic methods. | Ning Hua TAN Shou Xun ZHAO a Department of Phytochemistry,China Pharmaceutical University,Nanjing,210009 Jun ZHOU Hong Jie ZHANG De Zu WANG Chang Xiang CHEN Xiao Zhu LIU b Laboratory of Phytochemistry,Kunming Institute of Botany,Academia Sinica,Kunming,650204 | 1992 | Chinese Chemical Letters1992，3，8： | 4 |
| 9 | Sedation-risk-free colonoscopy for minimizing the burden of colorectal cancer screening显示文摘Unsedated colonoscopy is available worldwide,but is not a routine option in the United States(US).We conducted a literature review supplemented by our experience and expert commentaries to provide data to support the use of unsedated colonoscopy for colorectal cancer screening.Medline data from 1966 to 2009 were searched to identify relevant articles on the subject.Data were summarized and co-authors provided critiques as well as accounts of unsedated colonoscopy for screening and surveillance.Diagnostic colonoscopy was initially dev eloped as an unsedated procedure.Procedure-re lated discomfort led to wide adoption of sedation in the US,although unsedated colonoscopy remains the usual practice elsewhere.The increased use of colonoscopy for colorectal cancer screening in healthy,asymptomatic individuals suggests a reass-essment of the burden of sedation in colonoscopy for screening is appropriate in the US for lowering costs and minimizing complications for patients.A water method developed to minimize discomfort has shown promise to enhance outcomes of unsedated colonoscopy.The use of scheduled,unsedated colono scopy in the US appears to be feasible for colorectal cancer screening.Studies to assess its applicability in diverse practice settings deserve to be conducted and supported. | Felix W Leung Abdulrahman M Aljebreen Emilio Brocchi Eugene B Chang Wei-Chih Liao Takeshi Mizukami Melvin Schapiro Konstantinos Triantafyllou | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，3： | 3 |
| 10 | 植物纤维原料生物质提炼的可行性显示文摘提出一个单一的概念也许可以部分解决北美的两个主要问题,这个概念就是将不经济的硫酸盐浆厂转化为木材-乙醇工厂。当这种新工艺充分开发用于处理木材,这种也许是最难处理但也是最丰富的纤维素原料时,我们相信这些“重新规划”的硫酸盐浆厂能够成功地使用各种植物纤维素原料,包括中国的多种农作物原料和残余物。两个主要问题是:石油运输燃料将来的供应和成本以及化石燃料对全球气候变化的潜在影响;由于产能过剩,北美制浆造纸公司长期面临财政窘境。 | Richard B Phillips Hasan Jameel Hou-min Chang 马忻 | 2007 | 国际造纸2007，26，2： | 2 |
| 11 | Generalized set-valued variational inclusions in Banach spaces 显示文摘 | Chang S S Cho Y J Lee B S | 2000 | J Math Anal Appl2000，246，： | 2 |
| 12 | Differential cytotoxic T-lymphocyte responsiveness to the hepatitis B and C viruses in chronically infected patients 显示文摘 | Rehermann B Chang KM McHutchinson J | 1996 | J Virol1996，70，10： | 2 |
| 13 | Spatially adaptive wavelet thresholding with context modeling for image denoising显示文摘 | Chang S G Yu B Vetterlim M | 2000 | IEEE Transactions on Image Processing2000，9，9： | 2 |
| 14 | 分娩期连续电子胎心监护用于胎儿评估显示文摘 | ThackerS B Stroup D Chang M 朱洁萍 | 2006 | 生殖与避孕2006，26，2： | 2 |
| 15 | Tracking design of uncertain nonlinear SISO systems:adaptive fuzzy approach显示文摘 | CHEN B S LEE T S CHANG Y C | 1994 | IEEE Transactions on Fuzzy Systems1994，4，2： | 2 |
| 16 | Effect of weekend admission on geriatric hip fractures显示文摘BACKGROUND The care discrepancy for patients presenting to a hospital on the weekend relative to the work week is well documented.With respect to hip fractures,however,there is no consensus about the presence of a so-called“weekend effect”.This study sought to determine the effects,if any,of weekend admission on care of geriatric hip fractures admitted to a large tertiary care hospital.It was hypothesized that geriatric hip fracture patients admitted on a weekend would have longer times to medical optimization and surgery and increased complication and mortality rates relative to those admitted on a weekday.AIM To determine if weekend admission of geriatric hip fractures is associated with poor outcome measures and surgical delay.METHODS A retrospective chart review of operative geriatric hip fractures treated from 2015-2017 at a large tertiary care hospital was conducted.Two cohorts were compared:patients who arrived at the emergency department on a weekend,and those that arrived at the emergency department on a weekday.Primary outcome measures included mortality rate,complication rate,transfusion rate,and length of stay.Secondary outcome measures included time from emergency department arrival to surgery,time from emergency department arrival to medical optimization,and time from medical optimization to surgery.RESULTS There were no statistically significant differences in length of stay(P=0.2734),transfusion rate(P=0.9325),or mortality rate(P=0.3460)between the weekend and weekday cohorts.Complication rate was higher in patients who presented on a weekend compared to patients who presented on a weekday(13.3%vs 8.3%;P=0.044).Time from emergency department arrival to medical optimization(22.7 h vs 20.0 h;P=0.0015),time from medical optimization to surgery(13.9 h vs 10.8 h;P=0.0172),and time from emergency department arrival to surgery(42.7 h vs 32.5 h;P<0.0001)were all significantly longer in patients who presented to the hospital on a weekend compared to patients who presented to the hospital on a weekday.CONCLUSION This study provided insight into the“weekend effect”for geriatric hip fractures and found that day of presentation has a clinically significant impact on delivered care. | Jordan B Pasternack Matthew L Ciminero Michael Silver Joseph Chang Ronald J Simon Kevin K Kang | 2020 | World Journal of Orthopedics2020，11，9： | 2 |
| 17 | Load forecasting using support vector Machines: a study on EUNITE competition 2001 显示文摘 | Chen B J Chang M W Lin C J | 2004 | IEEE Transactions on Power Systems2004，19，4： | 1 |
| 18 | Small interfering RNA-induced suppression of ERCC1 enhances sensitivity of human cancer cells to cisplatin显示文摘 | CHANG I Y KIM M H KIM H B | 2005 | Bioehem Biophys Res Commun2005，327，1： | 1 |
| 19 | Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulccyte - macrophage colony - stimulating factor using ex vivo gene transfer 显示文摘 | Simons JW Mikhak B Chang JF | 1999 | Cancer Res1999，59，20： | 1 |
| 20 | Observations on changes in ultrasonically treated waste-activated sludge显示文摘 | Chu C P Chang B V Liao G S | 2001 | Wat Res2001，35，4： | 1 |
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