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4篇 您的检索式：作者名="Chang Shikuo"

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		题名	作者	年代	出处	被引量
	1	Multifunctional Reduced Graphene Oxide Hydrogel as Drug Carrier for Localized and Synergic Photothermal/Photodynamics/Chemo Therapy显示文摘To combine localized drug release with multimodal therapy for malignant tumor, a composite hydrogel as an integrative drug delivery system was facilely prepared. The system contains spinach extract(SE),reduced graphene oxide(r GO) and gold nanocages(Au NCs). SE conduces to the formation of hydrogel,and also serves as a green material for improving the biocompatibility of hydrogel, and a natural photosensitizer for killing tumor cells under laser radiation(660 nm). Au NCs show obvious photothermy and can enhance the generation of cytotoxic singlet oxygen(1O2). The composite hydrogel shell on tumor cells exhibits several competitive advantages including enhanced antitumor effect by retaining the high concentration of drugs around cancer cell, excellent PDT/PTT compatibility as well as high loading and controllable release of fluorouracil(5-FU) for synergetic multimodal treatment. The survival rate of He La cells incubated with 5-FU loaded hydrogel under NIR radiation for 10 min sharply decreases to 1.2%, indicating remarkably improved antitumor effects. These results demonstrate that the hydrogel is an excellent delivery carrier for localizable, NIR-responsive and combined PTT/PDT/Chemo synergetic antitumor.	Guanru Chang Shikuo Li Fangzhi Huang Xiuzhen Zhang Yuhua Shen Anjian Xie	2016	Journal of Materials Science & Technology2016，32，8：	1
	2	A Methodology for Deterministic Chinese Parsing显示文摘	Zhou Jingye Chang Shikuo	1986	Computer Processing of Chinese & Oriental Language1986，2，3：	1
	3	A visual language compiler for information retrieval by visual reasoning显示文摘	Chang Shikuo	1990	IEEE Transactions on Software Engineering1990，16，10：	1
	4	Iconic Indexing by 2-D Strings显示文摘	CHANG Shikuo SHI Qingyun Yan Chengwen	1987	lEEK Transactions on Pattern Analysis and Machine Intelligence1987，9，3：	1

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