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8篇 您的检索式：作者名="Chang WO"

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		题名	作者	年代	出处	被引量
	1	Proteaseactivated receptor signaling increases epithelial antimicrobial peptide expression显示文摘	Chang WO Hansen SR Rao D	2004	J Immunol2004，173，8：	1
	2	Three dimensional computerized tomograpgic analysis of the deformity of lateral growth disturbance of proximal femoral physis 显示文摘	Sun YJ Chang WO Leslie G	2009	J Pediatric Orthop2009，29，：	1
	3	Hg2+reduction and re-emission from simulated wet flue gas desulfurization liquors显示文摘	WO Jingjing ZHANG Meng CHANG Xiaoya	2009	Journal of Hazardous Materials2009，172，：	1
	4	Retrograde flexible in-tramedullary nailing in children’s femoral fractures显示文摘	Chang WO Park BC Poong-Taek K	2002	:413-4142002，，：	1
	5	Surgical management of an unruptured dural ateriovenous fistula of anterior cranial fossa显示文摘	So-Hyang I Chang WO Dae HH	2004	Surg Neurol2004，62，：	1
	6	Bandpass response of collinear beam acousto-optic tunable filters 显示文摘	I C Chang J Xu D Wo	1997	IEEE Transactions on Ultrasonics symposium1997，，：	1
	7	Preface显示文摘	Tao Xie He Jiang Ge Li Tianyu Wo Rahul Pandita Chang Xu Lihua Xu	2018	Journal of Computer Science & Technology2018，33，5：	0
	8	Reducing systemic absorption and macrophages clearance of genistein by lipid-coated nanocrystals for pulmonary delivery显示文摘Pulmonary delivery is an effective drug delivery strategy for the treatment of local respiratory diseases.However,the rapid systemic absorption through the lung due to the thin barrier and persistent lung clearances influence the drug retention in the lung.In this study,we designed a lipid-coated genistein nanocrystals(Lipo-NCs)formulation to achieve enhanced efficiency of local pulmonary delivery.The LipoNCs were fabricated by modifying genistein nanocrystals(NCs)with phospholipid membrane through thin film hydration following the homogenization method.The prepared Lipo-NCs exhibited a decreased drug release rate compared with the naked NCs.Our results demonstrated that intracellular uptake and transcellular transport of NCs by the Calu-3 epithelial layer were reduced after lipid coating.Furthermore,the macrophages clearance was also impeded by this Lipo-NCs formulation.In vivo lung retention and distribution revealed that more genistein was retained in the lung after intratracheal administration of Lipo-NCs.The pharmacokinetic study displayed that the AUC((0-t))values of Lipo-NCs were 1.59-fold lesser than those of the NCs group,indicating a reduced systemic absorption.In conclusion,this research indicated that Lipo-NCs could be a suitable formulation for reducing systemic absorption and macrophages clearance,and thus enhancing drug concentration in lung by pulmonary delivery.	Yuan He Chang Liu Run Han Yingmin Liang Judith Choi Wo Mak Yinghao Zhu Haifeng Li Ying Zheng	2023	Chinese Chemical Letters2023，34，1：	0

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