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| 1 | Astragalus polysaccharide enhances immunity and inhibits H9N2 avian influenza virus in vitro and in vivo显示文摘This study investigated the humoral immunization of Astragalus polysaccharide(APS) against H9N2 avian influenza virus(H9N2 AIV) infection in chickens. The effects of APS treatment on H9N2 infection was evaluated by an MTT [3(4, 5-dimethylthiazol-2-yl)-2, 3-diphenyl tetrazolium bromide] assay and analysis of MHC and cytokine mRNA expression. The effect on lymphocyte and serum antibody titers in vivo was also investigated. IL-4, IL-6, IL-10, LITAF, IL-12 and antibody titers to H9N2 AIV were enhanced in the first week after APS treatment. The results indicated that APS treatment reduces H9N2 AIV replication and promotes early humoral immune responses in young chickens. | Sanpha Kallon Xiaorong Li Jun Ji Cuiying Chen Qianyun Xi Shuang Chang Chunyi Xue Jingyun Ma Qingmei Xie Youngliang Zhang | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 48 |
| 2 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 3 | Aerodynamic Optimum Design of Transonic Turbine Cascades Using Genetic Algorithms显示文摘This paper presents an aerodynamic optimum design method for transonic turbine cascades based on the Genetic Algorithms coupled to the inviscid flow Euler solver and the boundary-layer calculation.The Genetic Algorithms control the evolution of a population of cascades towards an optimum design.The fitness value of each string is evaluated using the flow solver. The design procedur6 has been developed and the behavior of the genetic algorithms has been tested. The objective functions of the design examples are the minimum mean-square deviation between the aimed pressure and computed pressure and the minimum amount of user expertise. | Li Jun Feng Zhenping Chang Jianzhong Shen Zuda(Institute of Turbomachinery, School of Energy & Power Engineering, Xi’an Jiaotong University,Xi’an, Shaanxi, 710049, China) | 1997 | Journal of Thermal Science1997，6，2： | 6 |
| 4 | Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo显示文摘多重骨髓瘤(公里) 是第二很经常的恶意的 hematological 疾病。Dihydrocelastrol (DHCE ) 被 hydrogenated celastrol 综合,从中国药用的植物 Tripterygium regelii 孤立的 treterpene。在这研究,我们首先在公里房间上报导了 DHCE 的反肿瘤活动。我们发现 DHCE 能禁止房间增长并且在 vitro 通过 caspase 依赖的方法支持 apoptosis。另外, DHCE 能使 interleukin (IL ) 的表达式失去活性 -6 和 downregulate 细胞外的调整蛋白质 kinases (ERK1/2 ) 和信号变换器和在公里的抄写 3 的使活跃之物(STAT3 ) 的 phosphorylation。它也面对 IL-6 对公里房间线保留了它的活动。而且,有 DHCE 的公里房间的处理在房间周期的 G 0/G1 阶段导致了房间的累积。尤其是, DHCE 减少了 4 和 6 在公里房间衬里的 cyclin D1 和 cyclin 依赖的 kinases 的表示。另外,它向 MM 房间线的功效能与 histone deacetylase 禁止者 panobinostat (LBH589 ) 在联合被提高,它在公里作为潜在的治疗学的策略暗示了 DHCE 和 LBH589 的联合处理的可能性。另外,有 DHCE 的 NCI-H929 忍受肿瘤的裸体老鼠的处理(10 mg/kg/d, i.p, 1-14 天) 在 vivo 导致了肿瘤生长的 73% 抑制。一起拿,我们的现在的学习的结果显示 DHCE 能禁止细胞的增长并且在骨髓瘤房间导致房间 apoptosis 通过不同机制调停了,可能通过禁止 IL-6/STAT3 和 ERK1/2 小径。并且它可以为公里病人提供一种新治疗学的选择。 | Liangning Hu Huiqun Wu Bo Li Dongliang Song Guang Yang Gege Chen Bingqian Xie Zhijian Xu Yong Zhang Dandan Yu Jun Hou Wenqin Xiao Xi Sun Gaomei Chang Yiwen Zhang Lu Gao Bojie Dai Yi Tao Jumei Shi Weiliang Zhu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 5 |
| 5 | A new pyrrolidone derivative from Pistacia chinensis显示文摘新 N-phenyl-pyrrolidone 衍生物从 Pistacia 脊骨被孤立是 Bunge。它的结构作为 4-hydroxy-5-(2-oxo-1-pyrrolidinyl ) 被阐明安息香的酸的、命名 pistaciamide 根据 1D-NMR,系, HMQC 和 HMBC 分光镜的技术。 | Jian Jun Liu Chang An Geng Xi Kui Liu | 2008 | Chinese Chemical Letters2008，19，1： | 4 |
| 6 | Effects of Low Concentrations of Di-(2-ethylhexyl) and Mono-(2-ethylhexyl) Phthalate on Steroidogenesis Pathways and Apoptosis in the Murine Leydig Tumor Cell Line MLTC-1显示文摘这研究的目的是在 vitro 在一根鼠科的 Leydig 肿瘤房间线(MLTC-1 ) 在 steroidogenesis 上评估 DEHP 和 MEHP 的低集中的效果。流动 cytometry 分析的结果表明 apoptotic 房间的比例显著地在暴露以后被增加到 DEHP。所有三基因(P450scc, P450c17,并且 3 ? HSD ) 在学习下面显示出增加的表达式追随者暴露到 DEHP 或 MEHP,尽管一些不足道的禁止的效果出现了在 10 ? mol/L 处理组同样与控制相比。它也被发现那 DEHP 或 MEHP 在特别刺激了 INSL3 mRNA 和蛋白质 0.001 ? mol/L 处理组。睾丸激素分泌物在暴露以后被刺激到 DEHP 或 MEHP。在 MLTC-1 房间的 steroidogenic 酶和 INSL3 的改变可能在雄激素生产上涉及 DEHP/MEHP 的 biphasic 效果。 | CHEN Xi LIU Ya Nan ZHOU Qing Hong LENG Ling CHANG Ying TANG Nai Jun | 2013 | Biomedical and Environmental Sciences2013，26，12： | 4 |
| 7 | Short-segment Barrett's esophagus and cardia intestinal metaplasia:A comparative analysis显示文摘AIM:To investigate the endoscopy and histology of short-segment Barrett's esophagus (SSBE) and cardia intestinal metaplasia (CIM),and their correlation with Helicobacter pylori (H. pylori) gastritis and gastroesophageal reflux disease (GERD). METHODS:Biopsy specimens were taken from 32 SSBE patients and 41 CIM patients with normal appearance of the esophagogastric junction. Eight biopsy specimens from the lower esophagus,cardia,and gastric antrum were stained with hematoxylin/eosin,Alcian blue/periodic acid-Schiff,Alcian blue/high iron diamine and Gimenez dye. Results were graded independently by one pathologist. RESULTS:The SSBE patients were younger than the CIM patients (P < 0.01). The incidence of dysplasia and incomplete intestinal metaplasia subtype was higher in SSBE patients than in CIM patients (P < 0.01). H. pylori infection was correlated with antral intestinal metaplasia (P < 0.05),but not with reflux symptomatic,endoscopic,or histological markers of GERD in CIM patients. SSBE was correlated with reflux symptomatic and endoscopic esophagitis (P < 0.01),but not with H. pylori infection and antral intestinal metaplasia. CONCLUSION:Dysplasia risk is significantly greater in SSBE patients than in CIM patients. CIM is a manifestation of H. pylori-associated and multifocal atrophic gastritis,whereas SSBE may result from GERD. | Ying Chang,Digestive Endoscopic Center,Shanghai Sixth Hospital,Shanghai Jiao Tong University,Shanghai 200233,China Bin Liu,Department of Emergence Surgery,Shaanxi Provincial People’s Hospital,Xi’an 710068,Shaanxi Province,China Gui-Sheng Liu,Department of Gastroenterology,Shaanxi Provincial People’s Hospital,Xi’an 710068,Shaanxi Province,China Tao Wang,Department of Gastroenterology,First Hospital of Xi’ an Jiaotong University,Xi’an 710061,Shaanxi Province,China Jun Gong,Department of Gastroenterology,Second Hospital of Xi’an Jiaotong University,Xi’an 710004,Shaanxi Province,China | 2010 | World Journal of Gastroenterology2010，16，48： | 3 |
| 8 | Prognostic significance of regional lymphadenectomy in T1b gallbladder cancer:Results from 24 hospitals in China显示文摘BACKGROUND Whether regional lymphadenectomy(RL)should be routinely performed in patients with T1b gallbladder cancer(GBC)remains a subject of debate.AIM To investigate whether RL can improve the prognosis of patients with T1b GBC.METHODS We studied a multicenter cohort of patients with T1b GBC who underwent surgery between 2008 and 2016 at 24 hospitals in 13 provinces in China.The logrank test and Cox proportional hazards model were used to compare the overall survival(OS)of patients who underwent cholecystectomy(Ch)+RL and those who underwent Ch only.To investigate whether combined hepatectomy(Hep)improved OS in T1b patients,we studied patients who underwent Ch+RL to compare the OS of patients who underwent combined Hep and patients who did not.RESULTS Of the 121 patients(aged 61.9±10.1 years),77(63.6%)underwent Ch+RL,and 44(36.4%)underwent Ch only.Seven(9.1%)patients in the Ch+RL group had lymph node metastasis.The 5-year OS rate was significantly higher in the Ch+RL group than in the Ch group(76.3%vs 56.8%,P=0.036).Multivariate analysis showed that Ch+RL was significantly associated with improved OS(hazard ratio:0.51;95%confidence interval:0.26-0.99).Among the 77 patients who underwent Ch+RL,no survival improvement was found in patients who underwent combined Hep(5-year OS rate:79.5%for combined Hep and 76.1%for no Hep;P=0.50).CONCLUSION T1b GBC patients who underwent Ch+RL had a better prognosis than those who underwent Ch.Hep+Ch showed no improvement in prognosis in T1b GBC patients.Although recommended by both the National Comprehensive Cancer Network and Chinese Medical Association guidelines,RL was only performed in 63.6%of T1b GBC patients.Routine Ch+RL should be advised in T1b GBC. | Tai Ren Yong-Sheng Li Xue-Yi Dang Yang Li Zi-Yu Shao Run-Fa Bao Yi-Jun Shu Xu-An Wang Wen-Guang Wu Xiang-Song Wu Mao-Lan Li Hong Cao Kun-Hua Wang Hong-Yu Cai Chong Jin Hui-Han Jin Bo Yang Xiao-Qing Jiang Jian-Feng Gu Yun-Fu Cui Zai-Yang Zhang Chun-Fu Zhu Bei Sun Chao-Liu Dai Lin-Hui Zheng Jing-Yu Cao Zhe-Wei Fei Chang-Jun Liu Bing Li Jun Liu Ye-Ben Qian Yi Wang Ya-Wei Hua Xi Zhang Chang Liu Wan-Yee Lau Ying-Bin Liu | 2021 | World Journal of Gastrointestinal Surgery2021，13，2： | 3 |
| 9 | Comparative Proteomic Analysis in Left Ventricular Remodeling following Myocardial Infarction in Rats显示文摘Objective Left ventricular remodeling (LVR) following myocardial infarction (MI) is a key pathophysiological process in which MI develops into heart failure.The exact mechanism of LVR remains unclear.We performed differential proteomic analysis on the myocardia of rats with LVR after MI,to explore the mechanism of ventricular remodeling after MI.Methods In the LVR group (n=12),after the anterior descending coronary artery was ligated,the rats were fed for four weeks before the LVR models were established.Rats in the sham-operated group (n=11) underwent thread-drawing without ligation.The hemodynamic parameters,pathological findings,and proteomics were compared between the two groups.Results In the LVR group,the left ventricular end-diastolic pressure increased,the maximal left ventricular pressure increase/decrease ratio decreased significantly,and the left ventricular systolic pressure decreased.H-E staining and Masson staining of cardiac muscle tissues of the LVR group showed myocytolysis,disarray,and collagen proliferation.Twenty-one differentially expressed proteins were detected by proteomic analysis.We validated two proteins using western blot analysis.The differentially expressed proteins could be divided into six categories:energy metabolism-related proteins,cytoskeletal proteins,protein synthesis-related proteins,channel proteins,anti-oxidation-related proteins,and immune-related proteins.Conclusion These differentially expressed proteins might play key roles in LVR following MI. | GU Hong Juan GAO Chang Bin GONG Jun Li LI Xiang Jun SUN Bo LI Xi Ning | 2012 | Biomedical and Environmental Sciences2012，25，1： | 2 |
| 10 | A Portable Analog Lock-In Amplifier for Accurate Phase Measurement and Application in High-Precision Optical Oxygen Concentration Detection显示文摘 | Xi CHEN Jun CHANG Fupeng WANG Zongliang WANG Wei WEI Yuanyuan LIU Zengguang QIN | 2017 | Photonic Sensors2017，7，1： | 2 |
| 11 | Learning-based phase imaging using a low-bit-depth pattern显示文摘Phase imaging always deals with the problem of phase invisibility when capturing objects with existing light sensors.However,there is a demand for multiplane full intensity measurements and iterative propagation process or reliance on reference in most conventional approaches.In this paper,we present an end-to-end compressible phase imaging method based on deep neural networks,which can implement phase estimation using only binary measurements.A thin diffuser as a preprocessor is placed in front of the image sensor to implicitly encode the incoming wavefront information into the distortion and local variation of the generated speckles.Through the trained network,the phase profile of the object can be extracted from the discrete grains distributed in the low-bit-depth pattern.Our experiments demonstrate the faithful reconstruction with reasonable quality utilizing a single binary pattern and verify the high redundancy of the information in the intensity mcasurement for phase recovery.In addition to the advantages of efficiency and simplicity compared to now available imaging methods,our model provides significant compressibility for imaging data and can therefore facilitate the low-cost detection and efficient data transmission. | ZHENYU ZHOU JUN XIA JUN WU CHENLIANG CHANG XI YE SHUGUANG LI BNTAO DU HAO ZHANG GUODONG TONG | 2020 | Photonics Research2020，8，10： | 2 |
| 12 | Epidemiological Survey of Hemoglobinopathies Based on Next-Generation Sequencing Platform in Hunan Province,China显示文摘Objective This study was aimed at investigating the carrier rate of,and molecular variation in,α-andβ-globin gene mutations in Hunan Province.Methods We recruited 25,946 individuals attending premarital screening from 42 districts and counties in all 14 cities of Hunan Province.Hematological screening was performed,and molecular parameters were assessed.Results The overall carrier rate of thalassemia was 7.1%,including 4.83%forα-thalassemia,2.15%forβ-thalassemia,and 0.12%for bothα-andβ-thalassemia.The highest carrier rate of thalassemia was in Yongzhou(14.57%).The most abundant genotype ofα-thalassemia andβ-thalassemia was-α^(3.7)/αα(50.23%)andβ^(IVS-Ⅱ-654)/β^(N)(28.23%),respectively.Fourα-globin mutations[CD108(ACC>AAC),CAP+29(G>C),Hb Agrinio and Hb Cervantes]and sixβ-globin mutations[CAP+8(C>T),IVS-Ⅱ-848(C>T),-56(G>C),beta nt-77(G>C),codon 20/21(-TGGA)and Hb Knossos]had not previously been identified in China.Furthermore,this study provides the first report of the carrier rates of abnormal hemoglobin variants andα-globin triplication in Hunan Province,which were 0.49%and 1.99%,respectively.Conclusion Our study demonstrates the high complexity and diversity of thalassemia gene mutations in the Hunan population.The results should facilitate genetic counselling and the prevention of severe thalassemia in this region. | XI Hui LIU Qin XIE Dong Hua ZHOU Xu TANG Wang Lan TANG De Guo ZENG Chun Yan WANG Qiong NIE Xing Hui PENG Jin Ping GAO Xiao Ya WU Hong Liang ZHANG Hao Qing QIU Li FENG Zong Hui WANG Shu Yuan ZHOU Shu Xiang HE Jun ZHOU Shi Hao ZHOU Fa Qun ZHENG Jun Qing WANG Shun Yao CHEN Shi Ping ZHENG Zhi Fen MA Xiao Yuan FANG Jun Qun LIANG Chang Biao WANG Hua | 2023 | Biomedical and Environmental Sciences2023，36，2： | 1 |
| 13 | Au (Ⅲ), Ru(Ⅲ), In(Ⅲ), Bi(Ⅲ), Zr(Ⅳ), V(Ⅴ), Ga(Ⅲ) and Ti(Ⅳ) from solution samples显示文摘 | Chang Xi jun Su Qing qiao Liang Dong ying | 2002 | Talanta2002，57，： | 1 |
| 14 | Efficiency and mechanism of new poly (acryl-phenylamidrazone phenylhydrazide) chelating fiber for adsorbing trace Ga, In, Bi, V and Ti from solution 显示文摘 | Chang Xi jun Yang Xiu lan Wei Xin jie | 2001 | Analytica Chimica Acta2001，450，： | 1 |
| 15 | Synthesis and application of a novel poly (acryl-p-toluenesulfonamideamidine- p-tolue-nesul- fonylamide) chelating fiber for preeoneentration and separation of trace noble metal ions from solution samples 显示文摘 | Zheng Hong Chang Xi jun Lian Ning | 2005 | Microchim Acta2005，149，： | 1 |
| 16 | Preconcentration of trace metals with poly (acrylbenzoyl amidrazoneacrylbenzoyl hydrazine) chelating fiber 显示文摘 | Lian Ning Chang Xi jun Zheng Hong | 2006 | Solvent Extraction and Ion Exchange2006，24，： | 1 |
| 17 | A new benzophenone C-glycoside from Polygala telephioides Willd显示文摘A new benzophenone C-glucoside,3’-C-[4-O-(5-hydroxyferuloyl)-β-D-glucopyranosyl]-2′,4′,6′-trihydroxy-3,4-dimethoxy-benzophenone, named telephenone D,was isolated from the whole plants of Polygala telephioides,and its structure was determined by analysis of spectroscopic data. | Ting Jun Ma Chang Xi Jia | 2010 | Chinese Chemical Letters2010，21，5： | 1 |
| 18 | Individualization of tacrolimus dosage basing on cytochrome P450 3A5 polymorphism – a prospective, randomized, controlled study显示文摘 | Si‐Yang Chen Jia‐Li Li Fan‐Hang Meng Xue‐Ding Wang Tao Liu Jun Li Long‐Shan Liu Qian Fu Min Huang Chang‐Xi Wang | 2013 | Clin Transplant2013，，3： | 1 |
| 19 | Ambient Fine Particulate Matter Exposure and Blood Pressure:Evidence from a Large Chinese Multiple Follow-Up Study显示文摘Objective This study aimed to investigate the association of ambient PM_(2.5)exposure with blood pressure(BP)at the population level in China.Methods A total of 14,080 participants who had at least two valid blood pressure records were selected from the China Health and Retirement Longitudinal Survey during 2011–2015.Their long-term PM_(2.5)exposure was assessed at the geographical level,on the basis of a regular 0.1°×0.1°grid over China.A mixed-effects regression model was used to assess associations.Results Each decrease of 10μg/m^(3)in the 1 year-mean PM_(2.5)concentration(FPM1Y)was associated with a decrease of 1.24[95%confidence interval(CI):0.84–1.64]mmHg systolic BP(SBP)and 0.50(95%CI:0.25–0.75)mmHg diastolic BP(DBP),respectively.A robust association was observed between the long-term decrease in PM_(2.5)and decreased BP in the middle-aged and older population.Using a generalized additive mixed model,we further found that SBP increased nonlinearly overall with FPM1Y but in an approximately linear range when the FPM1Y concentration was<70μg/m^(3);In contrast,DBP increased approximately linearly without a clear threshold.Conclusion Efficient control of PM_(2.5)air pollution may promote vascular health in China.Our study provides robust scientific support for making the related air pollution control policies. | JIANGTULU Bahabaike LAN Chang Xin CHEN Jun Xi CHEN Xi WANG Bin XUE Tao | 2023 | Biomedical and Environmental Sciences2023，36，1： | 1 |
| 20 | The Synthesis of Some Novel N-[α-(Isoflavone-7-O-) Acetyl]Amino Acid Derivatives显示文摘A series of novel N-[α-(isoflavone-7-O-)acetyl] amino acid methyl esters were prepared from the efficient and regioselective alkylation of isoflavones with chloroacetyl amino acid derivatives under mild condition. | Peng LIU Jun Biao CHANG Rong Feng CHEN Qiang WANG Jing Xi XIE (Henan Institute of Chemistry, Henan Academy of Science, Zhengzhou 450002 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050) | 2000 | Chinese Chemical Letters2000，11，5： | 1 |
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