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| 1 | Peliosis hepatis complicated by portal hypertension following renal transplantation显示文摘Peliosis hepatis(PH)is a vascular lesion of the liver that mimics a hepatic tumor.PH is often associated with underlying conditions,such as chronic infection and tumor malignancies,or with the use of anabolic steroids,immunosuppressive drugs,and oral contraceptives.Most patients with PH are asymptomatic,but some present with abdominal distension and pain.In some cases,PH may induce intraperitoneal hemorrhage and portal hypertension.This study analyzed a 46-year-old male who received a transplanted kidney nine years prior and had undergone long-term immunosuppressive therapy following the renal transplantation.The patient experienced progressive abdominal distention and pain in the six months prior to this study.Initially,imaging studies revealed multiple liver tumor-like abnormalities,which were determined to be PH by pathological analysis.Because the hepatic lesions were progressively enlarged,the patient suffered from complications related to portal hypertension,such as intense ascites and esophageal varices bleeding.Although the patient was scheduled to undergo liver transplantation,he suffered hepatic failure and died prior to availability of a donor organ. | Chia-Ying Yu Liang-Che Chang Li-Wei Chen Tsung-Shih Lee Rong-Nan Chien Ming-Fang Hsieh Kun-Chun Chiang | 2014 | World Journal of Gastroenterology2014，20，9： | 11 |
| 2 | Preventing prolonged post-operative ileus in gastric cancer patients undergoing gastrectomy and intra-peritoneal chemotherapy显示文摘AIM: To assess the efficacy of metoclopramide (Met) for prevention of prolonged post-operative ileus in advanced gastric cancer patients undergoing D2 gastrectomy and intra-peritoneal chemotherapy (IPC).METHODS: Thirty-two advanced gastric cancer patients undergoing D2 gastrectomy and IPC were allocated to two groups. Sixteen patients received Met immediately after operation (group A), and 16 did not (group B). Another 16 patients who underwent D2 gastrectomy without IPC were enrolled as the control group (group C). All patients had received epidural pain control. The primary endpoints were time to first post-operative flatus and time until oral feeding with a soft diet without discomfort. Secondary endpoints were early complications during hospitalization.RESULTS: Gender, the type of resection, operating time,blood loss, tumor status and amount of narcotics were connparable in the three groups. However, the group C patients were older than those in groups A and B (67.5±17.7 vs 56.8±13.2, 57.5±11.7 years, P= 0.048). First bowel flatus occurred after 4.35±0.93 d in group A, 4.94±1.37 d in group B, and 4.71±1.22 d in group C (P>0.05). Oral feeding of a soft diet was tolerated 7.21±1.92 d after operation in group A, 10.15±2.17 d in group B, and 7.53±1.35 d in group C(groups A and C vsgroup B, P<0.05). There was no significant difference in respect to the first flatus among the three groups. However, the time of tolerating oral intake with soft food in groups A and C patients was significantly shorter than that in group B patients. Levels of C-reactive protein (CRP) were significantly lower in group C and there was a more prominent and prolonged response in CRP level in patients undergoing IPC. The incidence of post-operative complications was similar in the three groups except for prolonged post-operative ileus. There was no increased risk of anastomotic leakage in patients receiving Met.CONCLUSION: The results suggest that a combination of intravenous Met and epidural pain control may be required to achieve a considerable decrease in time to resumption of oral soft diet in advanced gastric cancer patients who underwent gastrectomy and IPC. Furthermore,the administration of Met did not increase anastomotic leakage. Met has a role in the prevention of prolonged post-operative ileus. | De-Chuan Chan Yao-Chi Liu Cheng-Jueng Chen Jyh-Cherng Yu Heng-Cheng Chu Fa-Chang Chen Teng-Wei Chen Huan-Fa Hsieh Tzu-Ming Chang Kuo-Liang Shen | 2005 | World Journal of Gastroenterology2005，11，31： | 9 |
| 3 | Co-infection of SENV-D among chronic hepatitis C patients treated with combination therapy with high-dose interferon-alfa and ribavirin显示文摘AIM: The clinical significance of co-infection of SENV-D among patients with chronic hepatitis C (CHC) and response of both viruses to combination therapy with high-dose interferon-alfa (IFN) plus ribavirin remain uncertain and are being investigated.METHODS: Total 164 (97 males and 67 females, the mean age 48.1±11.4 years, range: 20-73 years, 128histologically proved) naive CHC patients were enrolled in this study. SENV-D DNA was tested by PCR method.Detection of serum HCV RNA was performed using a standardized automated qualitative RT-PCR assay (COBAS AMPLICOR HCV Test, version 2.0). HCV genotypes 1a,1b, 2a, 2b, and 3a were determined by using genotypespecific primers. Pretreatment HCV RNA levels were determined by using the branched DNA assay (Quantiplex HCV RNA 3.0). There are 156 patients receiving combination therapy with IFN 6 MU plus ribavirin for 24 wk and the response to therapy is determined.RESULTS: Sixty-one (37.2%) patients were positive for SENV-D DNA and had higher mean age than those who were negative (50.7±10.6 years vs46.6±11.6 years,P = 0.026). The rate of sustained viral response (SVR)for HCV and SENV-D were 67.3% (105/156) and 56.3%(27/48), respectively. By univariate analysis, the higher rate of SVR was significantly related to HCV genotype non-1b (P<0.001), younger ages (P = 0.014), lower pretreatment levels of HCV RNA (P = 0.019) and higher histological activity index (HAI) score for intralobular regeneration and focal necrosis (P = 0.037). By multivariate analyses, HCV genotype non-1b, younger age and lower pretreatment HCV RNA levels were significantly associated with HCV SVR (odds ratio (OR)/95% confidence interval (CI): 12.098/0.02-0.19, 0.936/0.890-0.998, and 3.131/1.080-9.077, respectively). The SVR of SENV-D was higher among patients clearing SENV-D than those who had viremia at the end of therapy (P = 0.04).CONCLUSION: Coexistent SENV-D infection, apparently associated with higher ages, is found in more than onethird Taiwan Residents CHC patients. Both HCV and SENV-D are highly susceptible to combination therapy with high-dose IFN and ribavirin and SENV-D co-infection does not affect the HCV response. HCV genotype, pretreatment HCV RNA levels and age are predictive factors for HCV SVR. | Chia-Yen Dai Wan-Long Chuang Wen-Yu Chang Shinn-Chemg Chen Li-Po Lee Ming-Yen Hsieh Nei-Jen Hou Zu-Yau Un Ming-Yuh Hsieh Liang-Yen Wang Ming-Lung Yu | 2005 | World Journal of Gastroenterology2005，11，27： | 4 |
| 4 | The microstrueture and phase equilibrium of new high performance high - entropy alloys 显示文摘 | Ker - Chang Hsieh Cheng - Fu Yu Wen - Tai Hsieh Wei - Ren Chiang Jin Son Ku Jiun -Hui Lai Chin -Pan T Chih Chao Yang | 2008 | Journal of Alloys and Compounds2008，，8： | 1 |
| 5 | Immunotherapy for Bladder Cancer Using Recombinant Bacillus Calmette-Guerin DNA Vaccines and Interleukin-12 DNA Vaccine显示文摘 | CHI-FENG LEE SUN-YRAN CHANG DAR-SHIH HSIEH DAH-SHYONG YU | 2004 | The Journal of Urology2004，，3： | 1 |
| 6 | Comparison of clinical characteristics of combined hepatocellular‐cholangiocarcinoma and other primary liver cancers显示文摘 | Chern‐Horng Lee Sen‐Yung Hsieh Chee‐Jen Chang Yu‐Jr Lin | 2012 | J Gastroenterol Hepatol2012，，1： | 1 |
| 7 | Polymorphism of interferon–gamma gene at position +874 and clinical characteristics of chronic hepatitis C显示文摘 | Chia-Yen Dai Wan-Long Chuang Ming-Yen Hsieh Li-Po Lee Nai-Jen Hou Shinn-Cherng Chen Zu-Yau Lin Ming-Yuh Hsieh Liang-Yen Wang Jun-Fa Tsai Wen-Yu Chang Ming-Lung Yu | 2006 | Translational Research2006，，3： | 1 |
| 8 | Production, optimization growth conditions and properties of the xylanase from Aspergillus carneus M34 显示文摘 | Hsin Yu Fang Shin Min Chang Meng Chou Hsieh | 2007 | Journal of Molecular Catalysis B : Enzymatic2007，49，： | 1 |
| 9 | Intratypic variants of human papillomavirus type 16 and risk of cervical Neoplasia in Taiwan显示文摘 | Ya‐Ju Chang Hui‐Chi Chen Mei‐Hung Pan Bor‐Heng Lee San‐Lin You Ching‐Yu Lin Yi‐Chun Chou Chang‐Yao Hsieh Yu‐Juen Cheng Kai‐Li Liaw Ann W. Hsing Mark Schiffman Chien‐Jen Chen | 2013 | J. Med. Virol2013，，： | 1 |
| 10 | Are empiric antibiotics for acute exudative tonsillitis needed in children?显示文摘 | Tsung-Hsueh Hsieh Po-Yen Chen Fang-Liang Huang Jiann-Der Wang Li-Ching Wang Heng-Kuei Lin Hsiao-Chuan Lin Hsin-Yang Hsieh Meng-Kung Yu Chih-Feng Chang Tzu-Yau Chuang Chin-Yun Lee | 2011 | Journal of Microbiology Immunology and Infection2011，，5： | 1 |
| 11 | Acute Viral Hepatitis C-Induced Jaundice in Pregnancy显示文摘 | Tsung-Ying Hsieh Chen-Hsiang Yu Pao-Lin Kuo Fong-Ming Chang | 2006 | Taiwanese Journal of Obstetrics & Gynecology2006，，2： | 1 |
| 12 | DSM-RX78,a new phosphodiesterase inhibitor,suppresses superoxide anion production in activated human neutrophils and attenuates hemorrhagic shock-induced lung injury in rats显示文摘 | Yu HP Hsieh PW Chang YJ | 2009 | Biochem Pharmacol2009，78，8： | 1 |
| 13 | MicroRNA-30a increa- ses tight junction protein expression to suppress the epithelial- mesenchymal transition and metastasis by targeting Slug in breast caneer显示文摘 | CHANG CW YU JC HSIEH YH | 2016 | Oncotarget2016，7，16： | 1 |
| 14 | Char- acteristic of ground surface settlement during excavation 显示文摘 | Chang - Yu Ou Pio - Go Hsieh Dar - Chang Chiou | 1993 | Canadian Geotechnical Journal1993，，30： | 1 |
| 15 | Shape of ground surface settlement profiles caused by excavation 显示文摘 | Pio - Go Hsieh Chang - Yu Ou | 1998 | Canadian Geotechnical Journal1998，，35： | 1 |
| 16 | The value of multidetector-row computed tomography for localization of obscure acute gastrointestinal bleeding显示文摘 | Wei-Chou Chang Shih-Hung Tsai Wei-Kuo Chang Chang-Hsien Liu Ho-Jui Tung Chung-Bao Hsieh Guo-Shu Huang Hsian-He Hsu Chih-Yung Yu | 2010 | European Journal of Radiology2010，，2： | 1 |
| 17 | Femoral head avascular necrosis after interlocking nail of a femoral shaft fracture in a male adult: a case report显示文摘 | Chia-Chieh Wu Chen-Tung Yu Chen-Pu Hsieh Shih-Jen Chen Ing-Lin Chang | 2008 | Archives of Orthopaedic and Trauma Surgery2008，，4： | 1 |
| 18 | Pure-type clear cell carcinoma of the ovary as a distinct histological type and improved survival in patients treated with paclitaxel-platinum-based chemotherapy in pure-type advanced disease显示文摘 | Chih-Ming Ho Yun-Ju Huang Tze-Chien Chen Shih-Hung Huang Fu-Shing Liu Chan-Chao Chang Chien Mu-Hsien Yu Tsui-Lien Mao Tao-Yeuan Wang Chang-Yao Hsieh | 2004 | Gynecologic Oncology2004，，1： | 1 |
| 19 | Increasing Expression of GST-pi MIF, and ID1 Genes in Chemoresistant Prostate Cancer Cells显示文摘 | Yu D S Hsieh D S Chang S Y | 2006 | Arch Androl2006，52，4： | 1 |
| 20 | An alternative technique for totally implantable central venous access devices. A retrospective study of 1311 cases显示文摘 | H.M. Chang C.B. Hsieh H.F. Hsieh T.W. Chen C.J. Chen D.C. Chan J.C. Yu Y.C. Liu K.L. Shen | 2005 | European Journal of Surgical Oncology2005，，： | 1 |
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