| 1 | CT血流动力学用于乳腺癌诊断的ROC曲线分析(英文)显示文摘Objective:The aim of this study was evaluate the diagnostic value of computed tomography(CT) perfusion in breast cancer by the method of receiver operator characteristic curve(ROC) analysis.Methods:Eighty-one cases with breast masses found by health examination or mammography were scanned by multi-slice spiral CT(MSCT) perfusion and hemodynamic parameters of blood flow(BF), mean transit time(MTT) and blood volume(BV) were calculated by deconvolution arithmetic.According to the pathologic results, two groups, benign and malignant were classified and statistical analysis were performed between them.The ROC characteristics of BF, MTT, BV were compared for each and the diagnostic value of the hemodynamic parameters were confirmed.Results:In the malignant group, BF was(0.735 ± 0.440) mL/min/mL, MTT was(22.771 ± 7.647) s and BV was 0.234 ± 0.082.In the benign group, BF was(0.466 ± 0.527) mL/min/mL, MTT was(26.712 ± 12.934) s and BV was 0.179 ± 0.117.There was a significant difference for BF and BV between the benign and malignant groups.When the hemodynamic parameters were used to discriminate the breast lesions, the area under the ROC curve(AUCROC) of BF was 0.832 ± 0.086, the maximum, while AUCROC of BV was 0.695 ± 0.092.There was no significant statistical difference between BF and BV.AUCROC of MTT was 0.473 ± 0.102, which was minimal.Since the threshold of BF was 0.381 mL/min/mL, the sensitivity was 82.3%, the specificity was 73.2%, the positive likelihood ratio(LR) was 3.071 and the negative LR was 0.242.The threshold of BV was 0.190 with sensitivity 73.3%, specificity 56.5%, positive likelihood ratio 1.685 and negative LR 0.473.Conclusion:BF and BV among CT hemodynamic parameters have certain diagnostic value in breast cancer, but BF or BV can not yet be single index to confirm or deny the diagnosis. | Xiaodong Yuan Guokun Ao Changbin Quan Jing Zhang Peijun Wang Yuan Tian | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，3： | 1 |
| 2 | Retrospective case-analysis of the magnetic resonance imaging characteristics in the brain of patients with Wilson disease显示文摘BACKGROUND: Wilson disease (WD) damages liver, brain, kidney, cornea and nervous system severely. It is manifested in four ways: brain, liver, kidney and bone muscle. Whether or not magnetic resonance imaging (MRI) can clearly display the diseased region and range in brain of patient with WD, which provides imageological evidence for clinical practice, is unclear. OBJECTIVE: To observe the characteristics of MRI of brain in patient with SD, and analyze the correlation of diseased region with clinical symptoms. DESIGN: Retrospective case-analysis. SETTING: Department of Radiology, Second Hospital Affiliated to the General Hospital of Chinese PLA. PARTICIPANTS: Thirty-one patients, including 18 males and 13 females, with WD admitted to the Department of Neurology, Second Hospital Affiliated to the General Hospital of Chinese PLA between January 1999 and December 2005 were retrieved. The involved patients presented serum copper oxidase(sCP) activity decreasing and/or ceruloplasmin level decreasing and /or urinary copper content increasing; typical extrapyramidal symptoms and/or physical sign; abnormality showed by slit-lamp examination, Kayser-Fleischer ring positive. METHODS: ① All the involved patients underwent MRI examination. A GE 1.5T imaging equipment was used. Spin-echo sequence was adopted to perform T2 and T1 -weighed image at transverse axis level. Partial cases subjected to head scanning at coronal and/or sagittal level. Gd-DTPA with dosage of 0.1 mmol/kg was the strongest in 4 cases. ② MRI characteristics of patients with different clinical symptoms were observed. MAIN OUTCOME MEASURES: MRI detection results of patients with WD and MRI characteristics of patients with different clinical symptoms. RESULTS: Thirty-one patients with WD participated in the result analysis. ① Imageological examination results: WD involved many regions in the brain: dorsal caudate putamen (n =28), thalamencephalon(n =25), mesencephalon (n =25), globus pallidus (n =23), pons(n =21), posterior limb of internal capsule (n =16), dentate nucleus(n =16), caudate nucleus(n =15) and cerebral cortex (n =11). MRI presented hypo-intensity signal on T2 - weighted image and T1 -weighted image or isointensity signal on T1 -weighted image in 24 patients, characteristic hypo-intensity signal of globus pallidus in 4 patients, mixed signal of hyper- and hypo-intensity in 2 patients, hypo-intensity signal of globus pallidus, pars anterior pedunculi cerebri and pontine tegmentum on T1 - weighted image in 1 patient. Pathological changes distributed in symmetry and focus of infection mostly presented mottling, lamellar or strip. Different degrees of cerebral cortex atrophy, especially subtentorial cerebellar atrophy, were found in 20 patients. Four patients subjected to enhancement scanning, but no clear imaging was found. ③MRI characteristics of patients with different symptoms: Abnormal signal of dorsal caudate putamen was found in 28 patients with dystonia, 21 patients with dysarthria and 16 patients with bradykinesia; Abnormal signal of mesencephalon was found in 22 patients with trepidation, among which, 18 presented abnormal signal of pons; Abnormal signal of caudate nucleus and lenticular nucleus was found in 15 patients with dysphagia; Abnormal signal of dentate nucleus was found in 16 patients with cerebellar ataxia; Different degrees of changes in cerebral atrophy were found in 14 patients with deteriorating memory and dementia. CONCLUSION: MRI can clearly display the characteristics of diseased regions in brain of patient with WD. Diseased regions reflected by MRI have obvious differences in patients with different clinical neurosigns. | Hong Li Kun You Baoming He Jiagui Su Jian Hong Changbin Quan Min Zhao | 2006 | Neural Regeneration Research2006，1，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员