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1篇 您的检索式：作者名="Changjun Yn"

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		题名	作者	年代	出处	被引量
	1	CASP8 promoter polymorphism,mRNA expression and risk of prostate cancer among Chinese men显示文摘Caspase-8 (CASP8) plays a key role in apoptosis.We examined by genotyping whether the-652 six-nucleotide insertion-deletion (6N ins/del) polymorphism in the CASP8 promoter region was associated with prostate cancer risk in a hospital-based case-control study of 406 Chinese prostate cancer patients and 408 age-matched cancerfree controls.Additionally,23 prostate cancer tissues were analyzed for CASP8 mRNA expression.We found a significantly decreased prostate cancer risk for the 6N ins/del genotype [adjusted odds ratio (OR)=0.68;95% confidence interval (CI)=0.51-0.92] and del/del genotype (OR=0.34;95% CI=0.19-0.63) compared with the ins/ins genotype.The 6N del allele was associated dose-dependently with decreased prostate cancer risk (P trend=0.001).RT-PCR showed that individuals with the 6N del allele had lower CASP8 mRNA levels than those with the ins/ins genotype (P=0.024).These findings suggested that the CASP8-652 6N ins/del polymorphism may affect the susceptibility to prostate cancer and reduce prostate cancer risk among Chinese men.	Guangbo Fu Jialin Tang Meilin Wang Chao Qin Fu Yan Qi Ding Changjun Yn Xinru Wang Zhengdong Zhang	2011	The Journal of Biomedical Research2011，25，2：	0

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