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| 1 | 中国两栖动物保护需求总述显示文摘通过对中国两栖动物物种生物多样性现状的全面分析,与世界许多国家相比,中国是一个重要的全球优先保护地区.横断山区、南岭山区和武夷山区3个区域的两栖动物物种多样性特别丰富.有尾两栖类物种较无尾类受胁程度更高.几个物种数相对较少的铃蟾科、隐腮鲵科、小鲵科和蝾螈科显示出了高的受胁倾向.像世界其它地方一样,高海拔地区溪流繁殖的森林物种受胁程度更高.对中国两栖动物而言,生境丧失、污染和过度捕捉是最主要的致危因素.过度捕捉虽然影响不如生境丧失深远,但它更可能导致一个物种种群的快速衰落.针对5个方面的保护挑战,提出了优先研究领域和保护行动方面的建议. | 谢锋 刘惠宁 Simon N Stuart Janice S Chanson Neil A Cox Debra L Fischman | 2006 | 中国科学(C辑)2006，36，6： | 28 |
| 2 | Conservation needs of amphibians in China: A review显示文摘The conservation status of all the amphibians in China is analyzed,and the country is shown to be a global priority for conservation in comparison to many other countries of the world.Three Chinese regions are particularly rich in amphibian diversity:Hengduan,Nanling,and Wuyi mountains.Sala-manders are more threatened than frogs and toads.Several smaller families show a high propensity to become seriously threatened:Bombinatoridae,Cryptobranchidae,Hynobiidae and Salamandridae.Like other parts of the world,stream-breeding,high-elevation forest amphibians have a much higher likeli-hood of being seriously threatened.Habitat loss,pollution,and over-harvesting are the most serious threats to Chinese amphibians.Over-harvesting is a less pervasive threat than habitat loss,but it is more likely to drive a species into rapid decline.Five conservation challenges are mentioned with recommendations for the highest priority research and conservation actions. | Michael Wai Neng LAU Simon N STUART Janice S CHANSON Neil A COX Debra L FISCHMAN | 2007 | Science China(Life Sciences)2007，50，2： | 12 |
| 3 | Two-phase air-water flows: Scale effects in physical modeling显示文摘Physical modeling represents probably the oldest design tool in hydraulic engineering together with analytical approaches. In free surface flows, the similitude based upon a Froude similarity allows for a correct representation of the dominant forces, namely gravity and inertia. As a result fluid flow properties such as the capillary forces and the viscous forces might be incorrectly reproduced, affecting the air entrainment and transport capacity of a high-speed model flow. Small physical models operating under a Froude similitude systematically underestimate the air entrainment rate and air-water interfacial properties. To limit scale effects, minimal values of Reynolds or Weber number have to be respected. The present article summarizes the physical background of such limitations and their combination in terms of the Morton number. Based upon a literature review, the existing limits are presented and discussed, resulting in a series of more conservative recommendations in terms of air concentration scaling. For other air-water flow parameters, the selection of the criteria to assess scale effects is critical because some parameters(e.g., bubble sizes, turbulent scales) can be affected by scale effects, even in relatively large laboratory models. | PFISTER Michael CHANSON Hubert | 2014 | Journal of Hydrodynamics2014，26，2： | 7 |
| 4 | Physical modelling and scale effects of air-water flows on stepped spillways显示文摘During the last three decades, the introduction of new construction materials (e.g. RCC (Roller Compacted Concrete), strengthened gabions) has increased the interest for stepped channels and spillways. However stepped chute hydraulics is not simple, because of different flow regimes and importantly because of very-strong interactions between entrained air and turbu- lence. In this study, new air-water flow measurements were conducted in two large-size stepped chute facilities with two step heights in each facility to study experimental distortion caused by scale effects and the soundness of result extrapolation to pro- totypes. Experimental data included distributions of air concentration, air-water flow velocity, bubble frequency, bubble chord length and air-water flow turbulence intensity. For a Froude similitude, the results implied that scale effects were observed in both facilities, although the geometric scaling ratio was only Lr=2 in each case. The selection of the criterion for scale effects is a critical issue. For example, major differences (i.e. scale effects) were observed in terms of bubble chord sizes and turbulence levels al- though little scale effects were seen in terms of void fraction and velocity distributions. Overall the findings emphasize that physical modelling of stepped chutes based upon a Froude similitude is more sensitive to scale effects than classical smooth-invert chute studies, and this is consistent with basic dimensional analysis developed herein. | CHANSON Hubert GONZALEZ Carlos A. | 2005 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2005，6，3： | 5 |
| 5 | Turbulence and suspended sediment processes in the Garonne River tidal bore in November 2016显示文摘A tidal bore is a water discontinuity at the leading edge of a ood tide wave in estuaries with a large tidal range and funneling topography. New measurements were done in the Garonne River tidal bore on 14 15 November 2016, at a site previously investigated between 2010 and 2015. The data focused on long, continuous, high-frequency records of instantaneous velocity and suspended sediment con- centration (SSC) estimate for several hours during the late ebb, tidal bore passage and ood tide. The bore passage drastically modi ed the ow eld, with very intense turbulent and sediment mixing. This was evidenced with large and rapid uctuations of both velocity and Reynolds stress, as well as large SSCs during the ood tide. Granulometry data indicated larger grain sizes of suspended sediment in water samples compared to sediment bed material, with a broader distribution, shortly after the tidal bore. The tidal bore induced a sudden suspended sediment ux reversal and a large increase in suspended sedi- ment ux magnitude. The time-variations of turbulent velocity and suspended sediment properties indicated large uctuations throughout the entire data set. The ratio of integral time scales of SSC to velocity in the x-direction was on average TE,SSC/TE,x 0.16 during the late ebb tide, compared to TE,SSC/ TE,x 0.09 during the late ood tide. The results imply different time scales between turbulent velocities and suspended sediment concentrations. | David Reungoat Xinqian Leng Hubert Chanson | 2019 | International Journal of Sediment Research2019，34，5： | 5 |
| 6 | Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr-Cas9显示文摘Background: Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis(CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity, size, and airway characteristics, including the presence of submucosal glands.Methods: We describe the generation of a CF rat model(F508 del) homozygous for the p.Phe508 del mutation in the transmembrane conductance regulator(Cftr) gene. This model was compared to new Cftr-/-rats(CFTR KO). Target organs in CF were examined by histological staining of tissue sections and tooth enamel was quantified by micro-computed tomography. The activity of CFTR was evaluated by nasal potential difference(NPD) and short-circuit current measurements. The effect of VX-809 and VX-770 was analyzed on nasal epithelial primary cell cultures from F508 del rats.Results: Both newborn F508 del and Knock out(KO) animals developed intestinal obstruction that could be partly compensated by special diet combined with an osmotic laxative. The two rat models exhibited CF phenotypic anomalies such as vas deferens agenesis and tooth enamel defects. Histology of the intestine, pancreas, liver, and lungs was normal. Absence of CFTR function in KO rats was confirmed ex vivo by short-circuit current measurements on colon mucosae and in vivo by NPD, whereas residual CFTR activity was observed in F508 del rats. Exposure of F508 del CFTR nasal primary cultures to a combination of VX-809 and VX-770 improved CFTR-mediated Cl-transport.Conclusions: The F508 del rats reproduce the phenotypes observed in CFTR KO animals and represent a novel resource to advance the development of CF therapeutics. | Elise Dreano Marc Bacchetta Juliette Simonin Louise Galmiche Claire Usal Lotfi Slimani Jérémy Sadoine Laurent Tesson Ignacio Anegon Jean-Paul Concordet Aurélie Hatton Lucile Vignaud Danielle Tondelier Isabelle Sermet-Gaudelus Marc Chanson Charles-Henry Cottart | 2019 | Animal Models and Experimental Medicine2019，2，4： | 3 |
| 7 | Bubble entrainment, spray and splashing at hydraulic jumps显示文摘The sudden transition from a high-velocity, supercritical open channel flow into a slow-moving sub-critical flow is a hydraulic jump. Such a flow is characterised by a sudden rise of the free-surface, with some strong energy dissipation and air entrainment, waves and spray. New two-phase flow measurements were performed in the developing flow region using a large-size facility operating at large Reynolds numbers. The experimental results demonstrated the complexity of the flow with a developing mixing layer in which entrained bubbles are advected in a high shear stress flow. The relationship between bubble count rates and void fractions was non-unique in the shear zone, supporting earlier observations of some form of double diffusion process between momentum and air bubbles. In the upper region, the flow consisted primarily of water drops and packets sur-rounded by air. Visually significant pray and splashing were significant above the jump roller. The present study is the first com-prehensive study detailing the two-phase flow properties of both the bubbly and spray regions of hydraulic jumps, a first step towards understanding the interactions between bubble entrainment and droplet ejection processes. | CHANSON Hubert | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，8： | 2 |
| 8 | Air-water gas transfer at hydraulic jump with partially developed inflow显示文摘 | Hubert Chanson | 1995 | Water Res1995，29，10： | 1 |
| 9 | Blocking-aware processor voltage scheduling for real-time systems 显示文摘 | ZHANG Fang CHANSON S T | 2004 | ACM Trans on Embedded Computing Systems2004，3，2： | 1 |
| 10 | Metabolic syndrome in Cushing's syndrome 显示文摘 | Chanson P Salenave S | 2010 | Neuroendoerinol2010，92，1： | 1 |
| 11 | Acoustic doppler veloeimetry(ADV) in small estuary: field experi- ence and signal post -processing 显示文摘 | CHANSON H TREVETHEN M AOKI S | 2008 | Flow Measurement and Instrumentation2008，19，： | 1 |
| 12 | Hydraulics of stepped spillways:current status显示文摘 | CHANSON H | | 0，，09： | 1 |
| 13 | Improved strategies for dynamic load sharing显示文摘 | Hui C Chanson S | 1999 | IEEE Concurrency1999，7，3： | 1 |
| 14 | Undular tidal bores: basic theory and free-surface characteristics显示文摘 | CHANSON H | 2010 | Journal of Hydraulic Engineering2010，136，11： | 1 |
| 15 | Connexin37: a potential modifier gene of inflammatory disease显示文摘 | Marc Chanson Brenda R. Kwak | 2007 | Journal of Molecular Medicine2007，，8： | 1 |
| 16 | Rapid improvement in sleep apnoea of acromegaly after short-term treatment with somatostatinanalogue SMS 201-995显示文摘 | Chanson P Timsit J Benoit O | 1986 | Lancet1986，1，8492： | 1 |
| 17 | Macrophage migrationinhibitory factor deficiency is associated with impaired killing ofgram-negative bacteria by macrophages and increased suscepti-bility to Klebsiella pneumoniae sepsis显示文摘 | Roger T Delaloye J Chanson AL | 2013 | J Infect Dis2013，207，2： | 1 |
| 18 | Energy Dissipation Down a Stepped Spillway with Non-uniform Step Heights 显示文摘 | FELDER S CHANSON H | 2011 | Journal of Hydraulic Engineeriug2011，137，11： | 1 |
| 19 | Proteomic analysis reveals changes in the liver protein pattern of rats exposed to dietary folate deficiency显示文摘 | Chanson A Sayd T Rock E | 2005 | J Nutr2005，135，： | 1 |
| 20 | Connexin37: a potential modifier gene of inflammatory disease显示文摘 | Chanson M Kwak BR | 2007 | J Mol Med2007，85，8： | 1 |
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