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| 1 | 人工育苗条件下大黄鱼仔、稚、幼鱼的摄食与生长显示文摘在人工育苗条件下,对0到40日龄大黄鱼(Pseudosciaenacrocea,Richardson)仔、稚鱼及早期幼鱼的摄食习性与生长特性进行研究。水温(24±1)℃时,孵化后0~5d属于仔鱼期,6~20d为稚鱼期,第21天起转为幼鱼期。大黄鱼仔鱼孵化3d后开口摄食;开口时平均口径为240μm,40日龄达2480μm;口径的大小变化与日龄的关系是:y=0.2327e0.0682x,R2=0.9492。试验用的生物饵料与实际生产一致,包括轮虫、丰年虫无节幼体、活桡足类和冷藏桡足类。不同生长期的大黄鱼鱼苗的摄食活动具有明显的昼夜节律:在1昼夜(24h)中,仔鱼仅在18:00左右出现1个摄食高峰,而稚鱼和幼鱼除了在18:00左右出现1个显著的摄食高峰外,在10:00左右还有1个相对小的摄食高峰。仔、稚、幼鱼夜间基本不摄食。大黄鱼鱼苗具有较高的摄食率和饱食率,随着生长而迅速升高。仔、稚、幼鱼的生长速度具有明显的阶段性,1~2日龄仔鱼生长较快,5~9日龄生长减慢,21~30日龄生长加快,31~40日龄生长减慢。这与鱼苗的食物转换和饵料生物的营养变化有关:5~9日龄生长减慢是由于鱼苗由混合营养转变为外源性营养所致;31~40日龄生长减慢是因为冷藏桡足类的营养价值较低。鱼体全长与日龄的关系式为y=3.2552e0.0472x,R2=0.9710;体长与日龄的关系式为y=3.3205e0.0374x,R2=0.9777;? | 于海瑞 麦康森 段青源 马洪明 Chantal Cahu Jose Zambonino 刘付志国 谭北平 张文兵 徐玮 | 2003 | 中国水产科学2003，10，6： | 24 |
| 2 | Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion显示文摘Lysosome 是在 autophagic 进程的执行的一个关键 subcellular 细胞器,目前,很少被知道 lysosomal 功能是否在 autophagy 的进程被控制。在这研究,我们首先由饥饿或二 mTOR 发现 rapamycin (mTOR ) 的哺乳动物的目标的那抑制活动催化禁止者(PP242 和 Torin1 ) ,然而并非由一个 allosteric 禁止者(rapamycin ) ,导致 lysosomal 的激活功能。第二,我们提供了 lysosomal 功能的激活与 mTOR 建筑群 1 的抑制(mTORC1 ) 被联系的证据,然而并非 mTORC2,和到 lysosomes 的 mTORC1 本地化直接没在 lysosomal 功能被相关到它的规章的角色。第三,我们检验了抄写因素 EB (TFEB ) 的参与并且证明 TFEB 激活追随者 mTORC1 抑制为 lysosomal 激活必要然而并非足够。最后, Atg5 或 Atg7 删除或 autophagosome-lysosome 熔化过程的阻塞有效地减少了 lysosomal 激活,建议发生在 autophagy 期间的那 lysosomal 激活依赖于 autophagosome-lysosome 熔化。一起拿,这研究证明在 autophagy 期间, lysosomal 功能是经由包含 mTORC1 抑制和 autophagosome-lysosome 熔化的双机制的 upregulated。 | Jing Zhou Shi-Hao Tan Valerie Nicolas Chantal Bauvy Nai-Di Yang Jianbin Zhang Yuan Xue Patrice Codogno Han-Ming Shen | 2013 | Cell Research2013，23，4： | 16 |
| 3 | Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk显示文摘AIM: To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplémentation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected controls (n = 100). Conditional logistic regression models were used to investigate the associations between pre-diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory potential of the models. RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend = 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement = 0.01, RIDI = 26.5%). CONCLUSION: These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies. | Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela Sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow | 2012 | World Journal of Gastroenterology2012，18，22： | 15 |
| 4 | Activins and activin antagonists in hepatocellular carcinoma显示文摘In many parts of the world hepatocellular carcinoma (HCC)is among the leading causes of cancer-related mortality but the underlying molecular pathology is still insufficiently understood.There is increasing evidence that activins,which are members of the transforming growth factorβ(TGFβ)superfamily of growth and differentiation factors,could play important roles in liver carcinogenesis.Activins are disulphide-linked homo- or heterodimers formed from four differentβsubunits termedβA,βB,βC,andβE,respectively.Activin A, the dimer of twoβA subunits,is critically involved in the regulation of cell growth,apoptosis,and tissue architecture in the liver,while the hepatic function of other activins is largely unexplored so far.Negative regulators of activin signals include antagonists in the extracellular space like the binding proteins follistatin and FLRG,and at the cell membrane antagonistic coreceptors like Cripto or BAMBI.Additionally,in the intracellular space inhibitory Smads can modulate and control activin activity.Accumulating data suggest that deregulation of activin signals contributes to pathologic conditions such as chronic inflammation,fibrosis and development of cancer.The current article reviews the alterations in components of the activin signaling pathway that have been observed in HCC and discusses their potential significance for liver tumorigenesis. | Alev Deli Emanuel Kreidl Stefan Santifaller Barbara Trotter Katja Seir Walter Berger Rolf Schulte-Hermann Chantal Rodgarkia-Dara Michael Grusch | 2008 | World Journal of Gastroenterology2008，14，11： | 8 |
| 5 | 在藏羚羊上发现的中国第四种皮蝇显示文摘对于从可可西里藏羚羊上采集到的藏羚羊皮蝇Hypoderma sp.3龄幼虫进行了形态学观察,发现其在伪头、第10腹节上的刺、气门板形态上与中国现有记录的3种皮蝇(牛皮蝇、纹皮蝇和中华皮蝇)有着明显的区别。对藏羚羊皮蝇的线粒体COI基因种属特异性序列研究表明,其与牛皮蝇、纹皮蝇和中华皮蝇对应序列的相似性分别为88.1%,87.8%和88.8%。据此认为采自藏羚羊的此种皮蝇可能为中国境内又一皮蝇新种或新记录种,为中国第四种皮蝇。 | 庞程 蔡进忠 高兴春 李春花 曹杰 徐梅倩 刘生财 黄燕 朱顺海 Chantal BOULARD 何国声 | 2008 | 昆虫学报2008，51，10： | 8 |
| 6 | Wrist circumference: A new marker for insulin resistance in African women with polycystic ovary syndrome显示文摘BACKGROUND Insulin resistance(IR)is the main complication found in 35%-80%of women with polycystic ovary syndrome(PCOS).However,there is no definite consensus regarding which marker to use for its assessment in PCOS women.Research has shown that hyperinsulinemia is correlated with increased bone mass.Given that most women with PCOS are insulin resistant,which is independent from body fat and characterized by hyperinsulinemia,it could be hypothesized that there would be an increased bone mass in the patient as a result.Subsequently,increased bone mass could be measured using the wrist circumference method.AIM To assess the wrist circumference as an easy-to-detect marker of IR in Congolese women with PCOS.METHODS Seventy-two Congolese women with PCOS and seventy-one controls from the same ethnic group,were enrolled in the study(mean age 24.33±5.36 years).Fasting biochemical parameters,and the Homeostasis Model Assessment of insulin resistance(HOMA-IR)and body composition were evaluated.The nondominant wrist circumference was measured manually,as was the waist circumference(WC),hip circumference,height and weight.Calculated measures included evaluation of body mass index(BMI),Waist-to-Height(WHtR)and Waist-to-hip ratio(WHR).In addition,body composition was assessed by Bioelectrical Impedance Analysis using a body fat analyzer.RESULTS The non-dominant wrist circumference was more closely correlated with HOMAIR(r=0.346;P=0.003)and was the best anthropometrical marker correlated with IR(P=0.011)compared with other anthropometrical markers in women with PCOS:Dominant Wrist Circumference(r=0.315;P=0.007),Waist Circumference(WC)(r=0.259;P=0.028),BMI(r=0.285;P=0.016),WHR(r=0.216;P=0,068)and WHtR(r=0.263;P=0.027).The diagnostic accuracy of the non-dominant wrist circumference for the presence or absence of IR using Receiver-operating characteristic(ROC)curve analysis showed that the area under the ROC curve was 0.72.A cutoff value for the non-dominant wrist circumference of 16.3 cm was found to be the best predictor of IR in Congolese women with PCOS.CONCLUSION Non-dominant wrist circumference is,to date,the best anthropometrical marker of IR in Sub-Saharan African women with PCOS.It could be suggested as an easy-to-detect marker for assessing IR. | Chantal Anifa Amisi Massimo Ciccozzi Paolo Pozzilli | 2020 | World Journal of Diabetes2020，11，2： | 8 |
| 7 | 大黄鱼稚鱼L-蛋氨酸需要量的研究显示文摘研究了12—42日龄大黄鱼(Pseudosciaena crocea R.)稚鱼蛋氨酸需要量。以白鱼粉、磷虾粉和乌贼粉作蛋白源,通过添加L-晶体氨基酸使饲料与大黄鱼卵的必需氨基酸组成一致(蛋氨酸除外),制成6种等氮(8.8%)等能(16.65 kJ/g)的微黏合饲料。L-蛋氨酸梯度依次为饲料的1.19%、1.62%、2.18%、2.65%、3.13%和3.66%,或饲料蛋白的2.17%、2.95%、3.95%、4.81%、5.70%和6.65%。以生物饵料(丰年虫无节幼体和桡足类)作对照组。每处理设3个重复,每桶(180 L)内随机放3500尾初始体重为(1.93±0.11)mg的12日龄大黄鱼稚鱼。实验为期30d。结果显示,稚鱼的成活率随饲料蛋氨酸水平的升高而升高,在2.18%蛋氨酸水平时达到最高,之后无显著变化。特定生长率(SGR)随饲料蛋氨酸水平的升高而升高,在2.18%蛋氨酸水平时达到最高,之后则呈下降趋势。对照组稚鱼的成活率和SGR最高,均显著高于蛋氨酸组(P<0.05)。各组间稚鱼体脂肪和灰分差异不显著,但体蛋白随饲料蛋氨酸水平的升高而升高,在2.65%蛋氨酸水平时达到最高,之后则稍微下降;对照组鱼体蛋白和各必需氨基酸含量均显著高于其他组(P<0.05)。经二次多项式模型分析,12—42日龄大黄鱼稚鱼的蛋氨酸需要量为饲料的2.58%或饲料蛋白的4.69%。 | 于海瑞 艾庆辉 麦康森 José Luis Zambonino-Infante Chantal Louise Cahu | 2013 | 水生生物学报2013，37，6： | 7 |
| 8 | Gastric emptying evaluation by ultrasound prior colonoscopy:An easy tool following bowel preparation显示文摘AIM: To investigate the gastric emptying after bowel preparation to allow general anaesthesia. METHODS: A prospective, non-comparative, and nonrandomized trial was performed and registered on Eudra CT database(2011-002953-80) and on www.trial.gov(NCT01398098). All patients had a validated indication for colonoscopy and a preparation using sodium phosphate(NaP) tablets. The day of the procedure, patients took 4 tablets with 250 mL of water every 15 min, three times. The gastric volume wasestimated every 15 min from computed antral surfaces and weight according to the formula of Perlas et al(Anesthesiology, 2009). Colonoscopy was performed within the 6 h following the last intake.RESULTS: Thirty patients were prospectively included in the study from November 2011 to May 2012. The maximum volume of the antrum was 212 mL, achieved 15 min after the last intake. 24%, 67% and 92% of subjects had an antral volume below 20 mL at 60, 120 and 150 min, respectively. 81% of patients had a Boston score equal to 2 or 3 in each colonic segment. No adverse events leading to treatment discontinuation were reported.CONCLUSION: Gastric volume evaluation appeared to be a simple and reliable method for the assessment of gastric emptying. Data allow considering the NaP tablets bowel preparation in the morning of the procedure and confirming that gastric emptying is achieved after two hours, allowing general anaesthesia. | Romain Coriat Vanessa Polin Ammar Oudjit Franck Henri Marion Dhooge Sarah Leblanc Chantal Delchambre Anouk Esch Tessa Tabouret Maximilien Barret Frédéric Prat Stanislas Chaussade | 2014 | World Journal of Gastroenterology2014，20，37： | 6 |
| 9 | 伊维菌素4种剂型不同给药方法对牦牛皮蝇蛆病防治的比较研究显示文摘选用伊维菌素浇泼剂、注射剂、片剂、干混悬剂4种剂型,分别按0.5,0.2,0.3,0.3mg/kg体重剂量,对1.5岁牦牛在10月中旬给药,进行不同给药方法用于防治牦牛皮蝇蛆病的给药速度、劳动强度、使用的安全性、防治效果等方面的比较研究。结果:给药速度以浇泼剂最佳,其次为注射剂,再次为干混悬剂,片剂最慢;劳动强度以浇泼剂最佳,其次为注射剂与干混悬剂,再次为片剂;伊维菌素注射剂、浇泼剂和干混悬剂的防治效果佳,其驱净率和驱虫率均达100.00%,片剂较低,平均驱净率和驱虫率分别为95.41%和96.36%;同期检查阳性对照组牦牛皮蝇蛆平均感染率33.33%、平均感染强度7.5个虫体。试验表明,伊维菌素4种剂型防治牦牛皮蝇蛆病高效安全,其中浇泼剂优势明显。 | 蔡进忠 李春花 Boulard Chantal 何国声 孙延生 冯玉诚 Isabella Romboli 李春生 | 2013 | 青海畜牧兽医杂志2013，43，2： | 6 |
| 10 | 从单核细胞分化的树突状细胞的低温保存及其临床应用(英文)显示文摘树突状细胞 (dendriticcells,DCs)作为专职的抗原递呈细胞 ,已被广泛地应用于临床的肿瘤疫苗治疗。目前的临床方案大多为分次给病人注射 >10 6 个细胞 /次 ,不同批次培养的DCs,连续 4 - 6周。为了提高疗效 ,简化治疗程序及规范疗程 ,有必要将DCs低温保存 ,使患者在治疗过程中得到同批次的培养的DCs。本实验从患者外周血采取单个核细胞 ,经细胞淘洗分离单核细胞 ,在 80 0U/mlGM CSF + 10 0ng/mlIL 13的培养条件下 ,将单核细胞于Teflon疏水袋中诱导产生DCs。将DCs以 - 1℃梯度降温及不控温两种方式将DCs冻存于 - 80℃及液氮中。 1个月后 ,4 2℃快速复温。检测其免疫表型 (CD1a ,CD14,CD4 0 ,CD80 ,CD83,CD86,CD5 4 ,CD5 8,CD16,CD32 ,CD64,HLA DR)及其对自体及异体淋巴细胞的刺激作用。结果表明 ,2种方式的低温保存及复温过程不改变DCs的免疫表型及对淋巴细胞的刺激功能。结论 :应用Teflon袋 ,能够从外周血单核细胞中诱导出大批量的DCs ,这些DCs可被低温保存而不改变其功能 。 | VERG Véronique MARTINACHE Chantal LEON Anne GORIN Norbert-Claude BERNARD Jacky LOPEZ Manuel | 2000 | 中国实验血液学杂志2000，8，4： | 6 |
| 11 | Outer membrane VDAC1 controls permeability transition of the inner mitochondrial membrane in cellulo during stress-induced apoptosis显示文摘电压依赖者阴离子隧道(VDAC ) 1 是 mitochondrial 的主要隧道外部膜(妈妈) 和它被建议了是渗透转变毛孔(PTP ) 的部分, mitochondrial 渗透转变(MPT ) 的一个通常认为的 multiprotein 建筑群候选人代理人。在单个实时房间水平工作,我们发现 VDAC1 的 overexpression 在 mitochondrial 触发 MPT 内部膜(MIM ) 。相反地,在 MPT 的抑制的 silencing VDAC1 表示结果由导致亚硒酸盐的氧化应力引起了。这 MOM-MIM 串音被 Cyclosporin A 和 mitochondrial Cyclophilin D,然而并非由 Bcl-2 和 Bcl-XL 调制, PTP 的陈述语气操作。VDAC1 依赖的 MPT 雇佣包含反应的氧种类和 p38-MAPK 的一个积极反馈环,并且在第二包括 Bax 激活,细胞色素 c 版本和 caspase 触发正规 apoptotic 回答 3 激活。我们的数据因此支持在 MOM 包含 VDAC1 的 PTP 建筑群的一个模型,并且显示 VDAC1 依赖的 MPT 是在氧化导致压力的 apoptosis 起一个原因的作用的在上游的机制。 | Flora Tomasello Angela Messina Lydia Lartigue Laura Schembri Chantal Medina Simona Reina Didier Thoraval Marc Crouzet Frangois Ichas Vito De Pinto Francesca De Giorgi | 2009 | Cell Research2009，19，12： | 6 |
| 12 | 成年大鼠睾丸经EDs处理后再生睾丸间质细胞基因图谱的改变显示文摘成年睾丸间质细胞(ALC)是睾丸中产生雄激素的唯一内分泌细胞,只占有睾丸细胞的1%-5%。大鼠睾丸中的睾丸间质细胞被EDs去除后能够再生。本研究中,我们主要研究了大鼠睾丸经EDS处理后睾丸间质细胞再生及基因的变化图谱。EDS处理后7、21、35、90天后分析血清中睾酮、睾丸基因图谱和一些类固醇生成相关的蛋白变化情况。EDS处理后第7天睾丸中睾酮水平几乎检测不到,然后开始恢复。处理后7天,81个基因下调2倍或者更多,其中48个基因检测不到,包括类固醇合成通路中的蛋白Star、Scarbl、Cypllal、Cypl7al、Hsd3bl、CyplblICyp2al。这些基因在21天开始表达增多,到90天已经完全恢复到正常水平。89个基因上调2倍或者更高,nPkib。这些上调的基因到90天恢复正常;其中Cyp2al直到35天才开始恢复,表明这个基因只在成年睾丸间质细胞中表达,不在前体细胞中表达。qPCR,Westernblot、半定量免疫组织染色检测了随机抽取的基因和蛋白确认其变化情况。 | Yu-Fei Zhang Kai-Ming Yuan Yong Liang Yan-Hui Chu Qing-Quan Lian Yu-Fei Ge Wei Zhen Chantal M Sottas Zhi-Jian Su Ren-Shan Ge | 2015 | Asian Journal of Andrology2015，17，2： | 5 |
| 13 | Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain显示文摘Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely with low morbidity. The recipient operation carries a major morbidity indicating an important learning curve. Shifting the risk from the donor to the recipient, by moving from the larger right-liver to the smaller left-liver grafts, should be further explored as this policy makes donor hepatectomy safer and may stimulate the development of transplant oncology. | Samuele Iesari Milton Eduardo Inostroza Nú?ez Juan Manuel Rico Juri Olga Ciccarelli Eliano Bonaccorsi-Riani Laurent Coubeau Pierre-Fran?ois Laterre Pierre Goffette Chantal De Reyck Beno?t Lengelé Pierre Gianello Jan Lerut | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 5 |
| 14 | 初乳摄入量:影响仔猪生产性能和变化的因素显示文摘初乳摄入不足是仔猪在出生后最初几天内死亡的根本原因。最新的研究发现,据估计每头仔猪在出生后的24 h内摄入200 g初乳,是显著降低其断奶前死亡风险、产生被动免疫力以及能够实现轻微增重的最低摄入量。为使仔猪拥有良好的健康以及在断奶前后取得合理的生长速度,建议让仔猪摄入250 g的初乳。根据这一标准,至少三分之一的母猪不能产生足够满足所有仔猪需求的初乳量。因此,我们必须考虑使用多种可以增加仔猪初乳摄入量的方法,例如增强仔猪吮吸能力、减少窝内仔猪初生重的差异以及提高母猪初乳质量等。对母猪妊娠期间营养的研究已经获得了令人振奋的结果,尤其是在仔猪出生时的活力以及获得被动免疫力方面。侧重于营养或遗传选种的方法,预期也可以提高母猪窝产仔猪初生重的均匀性。最后,很明显,有关提高母猪初乳产量的方法还需要进一步研究。一个已被忽略但还需要更多研究的领域是乳腺发育对初乳产量的潜在影响。未来,研究重点应集中在母猪青春期和孕期最后几天的激素水平和营养状况对初乳产量的影响。 | 唐彩琰 Hélène Quesnel Chantal Farmer Nicolas Devillers | 2017 | 国外畜牧学(猪与禽)2017，0，9： | 5 |
| 15 | 微颗粒饲料与冷藏桡足类对大黄鱼稚鱼消化酶活力、肠和肝脏显微结构的影响显示文摘以初始体重(13.80±0.40)mg的大黄鱼(Pseudosciaena crocea R.)稚鱼为对象,在室内系统内进行饲养试验,研究了新开发的3种微颗粒饲料(Diet 1–Diet 3)、混合饲料(Diet 4:Diet 3和冷藏桡足类)与冷藏桡足类(Diet 5,对照组)对25—60日龄大黄鱼稚鱼消化酶活力、肠和肝脏显微结构的影响。结果显示,35和60日龄时,微颗粒饲料组鱼苗间的胰蛋白酶活力差异不显著(P>0.05),但均较25日龄时高,而混合组和对照组无显著变化。除对照组鱼苗35日龄时的胰淀粉酶活力显著(P<0.05)高于25和60日龄外,其他各组间均无显著差异。随着鱼苗的生长,除混合组和对照组外,各组间鱼苗肠道氨肽酶和碱性磷酸酶活力均逐渐升高。组织学结果显示,混合组35日龄鱼苗前中肠黏膜上有大量脂滴,而其他各组鱼苗则没有。微颗粒饲料组鱼苗肠黏膜褶皱比混合组和对照组多且深,直肠黏膜上皮细胞中可见脂滴积累,而对照组鱼苗直肠几乎没有褶皱,并缺乏脂滴。微颗粒饲料组鱼苗肝细胞内有大量脂滴,胞核移向细胞外周。混合组鱼苗35日龄时肝细胞内也有脂滴,但数量在60日龄时减少。对照组鱼苗肝脏中可见类似于饥饿状态的胞间隙、细胞质塌陷和胞核固缩。以上结果表明,合适的微颗粒饲料可促进大黄鱼稚鱼消化道的发育。基于Diet 1效果优于Diet 2和Diet 3,可将其作为进一步研究大黄鱼稚鱼营养和微颗粒饲料的基础配方。 | 于海瑞 艾庆辉 麦康森 马洪明 Jose Luis Zambonino-Infante Chantal Louise Cahu | 2012 | 水生生物学报2012，36，6： | 5 |
| 16 | 微颗粒饲料与冰冻桡足类对大黄鱼稚鱼生长、存活和体成分的影响(英文)显示文摘评估三种新开发的微颗粒饲料(Diet 1,Diet 2和Diet 3)、一种混合饲料(Diet 4:Diet 3和冰冻桡足类混合投喂)和冰冻桡足类(Diet 5)对25–60日龄大黄鱼稚鱼的饲喂效果。Diet 1组大黄鱼稚鱼的特定生长率(SGR,7.97%/d)和成活率(40.0%)最高,而Diet 5组稚鱼的SGR(4.15%/d)和成活率(20.4%)最低。Diet 4组稚鱼的成活率与Diet 1组差异不显著,但其SGR低于后者。从稚鱼的SGR和成活率看,三种微颗粒饲料中,Diet 1要优于Diet 2和Diet 3。各处理组中每桶稚鱼的生物量与SGR有相似的变化趋势。各微颗粒饲料组稚鱼的体蛋白含量差异不显著,低于Diet 4组,但高于Diet 5组。而微颗粒饲料组稚鱼的脂肪含量(10.6%–13.3%)均显著高于Diet 4组(7.6%)和Diet 5组(7.2%)。尽管冷冻桡足类中C20:4n–6(AA)的含量稍低于微颗粒饲料,但Diet 4和Diet 5组稚鱼的AA含量均显著高于微颗粒饲料组。Diet 4和Diet 5组稚鱼的C22:6n–3(DHA)分别高于其相应饲料中的含量。相反地,微颗粒饲料组稚鱼的C20:5n–3(EPA)低于微颗粒饲料中的含量。这些结果表明,Diet 4和Diet 5组稚鱼体内AA、DHA和EPA的沉积效率高于微颗粒饲料组。研究表明,大黄鱼稚鱼可用微颗粒饲料'断奶'。基于Diet 1优于Diet 2和Diet 3,可将其作为进一步研究的基础配方。此外,有必要对各处理组大黄鱼稚鱼消化酶和消化道的变化进行研究以综合评估微颗粒饲料的效果。 | 于海瑞 麦康森 马洪明 艾庆辉 段青源 Jose Luis Zambonino-Infante Chantal Louise Cahu | 2012 | 水生生物学报2012，36，1： | 5 |
| 17 | Improving outcomes of biliary atresia: French national series 1986–2009显示文摘 | Christophe Chardot Chantal Buet Marie-Odile Serinet Jean-Louis Golmard Alain Lachaux Bertrand Roquelaure Frédéric Gottrand Pierre Broué Alain Dabadie Frédéric Gauthier Emmanuel Jacquemin | 2013 | Journal of Hepatology2013，，6： | 4 |
| 18 | Disease control with sunitinib in advanced intrahepatic cholangiocarcinoma resistant to gemcitabine-oxaliplatin chemotherapy显示文摘Advanced cholangiocarcinoma is associated with poor prognostic survival and has limited therapeutic options available at present. The importance of angiogenesis and expression of pro-angiogenic factors in intrahepatic forms of cholangiocarcinoma suggest that therapies targeting angiogenesis might be useful for the treatment of this disease. Here we report three cases of patients with advanced intrahepatic cholangiocarcinoma progressive after standard chemotherapy and treated with sunitinib 50 mg/d in 6-wk cycles of 4 wk on treatment followed by 2 wk off treatment(Schedule 4/2). In all three patients, sunitinib treatment was associated with a sustained disease control superior to 4 mo, patients achieving either a partial response or stable disease. A reduction in tumor size and density was observed in all cases, suggesting tumor necrosis as a result of sunitinib treatment in these patients. In addition, sunitinib was generally well tolerated and the occurrence of side effects was managed with standard medical interventions, as required. Our results suggest that sunitinib therapy maybe associated with favorable outcomes and tolerability in patients with advanced cholangiocarcinoma. Those observations contributed to launch a prospective phase Ⅱ multicenter trial investigating sunitinib in advanced intrahepatic cholangiocarcinoma(SUN-CK study; NCT01718327). | Chantal Dreyer Marie-Paule Sablin Mohamed Bouattour Cindy Neuzillet Maxime Ronot Safi Dokmak Jacques Belghiti Nathalie Guedj Valérie Paradis Eric Raymond Sandrine Faivre | 2015 | World Journal of Hepatology2015，7，6： | 4 |
| 19 | 不同灌水下限再生水灌溉对土壤-小白菜的影响研究显示文摘再生水灌溉的安全开展取决于合适的灌溉水质和灌溉制度,为了探明生活污水用于短生育期作物灌溉的可行性并寻求适宜的灌溉制度,以小白菜作为研究对象,采用2种水质(清水、再生水)和4个灌水下限(60%、70%、80%和90%的田间持水率)的两因素盆栽试验,研究了不同灌水下限下再生水灌溉对作物产量和全氮、全磷、重金属(Cu、Cd和Pb)等品质指标以及对土壤盐分、肥力和重金属的影响。结果表明:再生水灌溉对小白菜产量的影响较小,对小白菜吸收氮、磷和重金属的能力影响不显著,而小白菜对不同重金属的吸收能力表现出显著的差异。与清水相比,再生水灌溉条件下土壤有机质、速效氮和速效磷均有增加,且与灌水下限有显著的正相关,同时也会导致土壤盐分的增加、而土壤重金属无明显差异。总而言之,再生水适用于小白菜的灌溉,但不能直接移用清水灌溉的灌溉制度。 | 廖林仙 举健 邵孝侯 Kwizera Chantal | 2014 | 中国农学通报2014，30，14： | 4 |
| 20 | C-reactive protein levels during a relapse of Crohn’s disease are associated with the clinical course of the disease显示文摘AIM: To explore if C-reactive protein (CRP) levels might serve as a prognostic factor with respect to the clinical course of Crohn's disease and might be useful for classification.METHODS: In this retrospective cohort study we enrolled 94 patients from the inflammatory bowel disease (IBD) database of the University Medical Centre Utrecht. CRP levels during relapse were correlated with the number of relapses per year. Severity of relapses was based on endoscopic reports and prednisone use. Furthermore, patients were categorized in a low or high CRP group based on their CRP response during relapse and demographic and clinical features were compared.RESULTS: Overall, a positive correlation between CRP levels, number of relapses, and severity of relapse was found (respectively rs = 0.31, P < 0.01 and rs = 0.50, P < 0.001). Employing a cut-off level of 15 mg/L, the index CRP level was found to discriminate patients with respect to the number of relapses per year, as well as for severity of relapses (respectively 0.25 ± 0.16 vs 0.36 ± 0.24, P < 0.05 and 4.4 ± 1.2 vs 3.2 ± 1.1 on a 10-point visual analogue scale, P < 0.001 for the high CRP and low CRP groups respectively). In addition, the high CRP group showed more cumulative days of prednisone use per year (107 ± 95 vs 58 ± 48, P < 0.05), as well as a better response to infliximab (93 % vs 33 %, P = 0.06).CONCLUSION: A higher CRP level during relapse seems to be associated with a more severe clinical course of disease. | Chantal L Koelewijn Matthijs P Schwartz Melvin Samsom Bas Oldenburg | 2008 | World Journal of Gastroenterology2008，14，1： | 4 |
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