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| 1 | Thymosin Alpha-1 Inhibits Complete Freund’s Adjuvant-Induced Pain and Production of Microglia-Mediated Pro-inflammatory Cytokines in Spinal Cord显示文摘Activation of inflammatory responses regulates the transmission of pain pathways through an integrated network in the peripheral and central nervous systems.The immunopotentiator thymosin alpha-1(Tal)has recently been reported to have anti-inflammatory and neuroprotective functions in rodents.However,how Tα1 affects inflammatory pain remains unclear.In the present study,intraperitoneal injection of Tal attenuated complete Freund's adjuvant(CFA)-induced pain hypersensitivity,and decreased the up-regulation of pro-inflammatory cytokines(TNF-α,IL-1β,and IL-6)in inflamed skin and the spinal cord.We found that CFA-induced peripheral inflammation evoked strong microglial activation,but the effect was reversed by Tα1.Notably,Tα1 reversed the CFA-induced up-regulation of vesicular glutamate transporter(VGLUT)and down-regulated the vesicular γ-aminobutyric acid transporter(VGAT)in the spinal cord.Taken together,these results suggest that Tα1 plays a therapeutic role in inflammatory pain and in the modulation of microgliainduced pro-inflammatory cytokine production in addition to mediation of VGLUT and VGAT expression in the spinal cord. | Yunlong Xu Yanjun Jiang Lin Wang Jiahua Huang Junmao Wen Hang Lv Xiaoli Wu Chaofan Wan Chuanxin Yu Wenjie Zhang Jiaying Zhao Yinqi Zhou Yongjun Chen | 2019 | Neuroscience Bulletin2019，35，4： | 4 |
| 2 | High Temperature Flexural Deformation Properties of Engineered Cementitious Composites (ECC) with Hybrid Fiber Reinforcement显示文摘Engineered Cementitious Composites(ECC)is a class of high-performance fiber reinforced composites with ultra-ductility designed based on micromechanics,and it has been developed for increasing application in the construction industry during recent decades.The properties of ECC at room temperature have been tested and studied in depth,however,few studies focus on its performance after high temperature that is one of the worst conditions to ECC.To investigate the change tendency and mechanism for the high temperature flexural properties of hybrid fiber reinforced ECC and the feasibility of calcium carbonate whisker to reduce the cost of ECC materials,polyvinyl alcohol fiber(PVA)reinforced strain hardening cementitious composites(PVA-ECC),steel fiber+PVA fiber reinforced ECC(defined as HyFRECC-A)and steel fiber+PVA fiber+CaCO3 whisker reinforced ECC(defined as HyFRECC-B)subject to room temperature and 200℃,400℃,600℃,800℃elevated temperature exposure were experimentally compared.The results indicate that equally replacing PVA fibers by steel fibers degraded the flexural hardening ability of PVA-ECC at room temperature,while the addition of appropriate amount of CaCO3 whisker improved the flexural strength,toughness and flexural hardening behavior.The elevated temperature posed a significant effect on the flexural strength and toughness of the three types of ECCs.Flexural deflection hardening behavior of the three types of ECCs was eliminated after high temperature exposure.Flexural strength and toughness of PVA-ECC presented an exponential decay along with the increase of temperature.The addition of steel fiber slowed down the decay rate.Although the use of CaCO3 whisker increased the post-temperature flexural strength and toughness of HyFRECC-B,the decay rate was not further decreased. | Zhihui YU Zhen YUAN Chaofan XIA Cong ZHANG | 2020 | Research and Application of Materials Science2020，2，2： | 3 |
| 3 | Dynamic thermal coupling modeling and analysis of wet electro-hydrostatic actuator显示文摘The electro-hydrostatic actuator(EHA)used in more electric aircraft(MEA)has been extensively studied due to its advantages of high reliability and high integration.However,this high integration results in a small heat dissipation area,leading to high-temperature problems.Generally,to reduce the temperature,a wet cooling method of using the pump leakage oil to cool the motor is adopted,which can also increase the difficulty of accurately predicting the system temperature in the early design stage.To solve this problem,a dynamic coupling thermal model of a wet EHA is proposed in this paper.In particular,the leakage oil of the pump is used as a coupling item between the electrical system and the hydraulic system.Then,an improved T-equivalent block model is proposed to address the uneven distribution of axial oil temperature inside the motor,and the control node method is applied to hydraulic system thermal modeling.Meanwhile,a dynamic coupling thermal model is developed that enables a dynamic evaluation of the wet EHA temperature.Then,experimental prototypes of wet motor and wet EHA are developed,while the temperature response of the wet motor at different rotation speeds and different loads and the temperature response of the wet EHA at no-load condition were verified experimentally at room temperature,respectively.The maximum temperature difference between the experimental and theoretical results of the wet motor as well as the experimental and theoretical results of the wet EHA is less than 8℃.These test results indicate that the dynamic coupling thermal model is valid and demonstrate that the thermal coupling modeling method proposed in this paper can provide a basis for the detailed thermal design of EHA. | Zongxia JIAO Yanpeng LI Tian YU Chaofan JIANG Ligang HUANG Yaoxing SHANG | 2022 | Chinese Journal of Aeronautics2022，35，6： | 2 |
| 4 | How urbanization affect the ecosystem health of Tibet based on terrain gradients:a case study of Shannan,China显示文摘Urbanization has significant impacts on ecosystem health(ESH)by affecting land-use patterns.The evaluation of the ESH and the spatial correlations between human interference provides an insight into sustainable development as a response to potential ecological degradation if ESH is threatened by further urbanization.We applied the Vigor-Organization-Resilience-Services(VORS)modelto detect the responses of ESH of Shannan Prefecture in the Tibet to urbanization from 1990 to 2015,based on different levels of terrain gradients.The results show that the ESH of the most areas in Shannan reaches the levels of highest health and average health during the study period.By 2015,the area proportion at the highest health level increased by 0.68%,while that of degraded level decreased by 1.51%.Overall,the ESH of areas tends to shrink at higher-level TGs,and urban sprawl with ESH shrinking existed in middle-level TGs in Shannan.Furthermore,a significant spatial aggregation effect was found concerning that low ESH-high CUL type is mainly distributed on the middle-level TGs with dense human population.The results highlight the needs to rationally organize urbanization process in plateau regions based on different TGs,which contribute to maintain ESH advancing people livelihood improvement. | Ji Zhang Yu Shi Chaofan Xian Lu Zhang Ziying Zou | 2022 | Ecosystem Health and Sustainability2022，8，1： | 1 |
| 5 | Rapid and mass manufacturing of soft hydrogel microstructures for cell patterns assisted by 3D printing显示文摘Micro-/nano-patterns on hydrogels are widely used in cell patterning.However,manufacturing molds with traditional lithography is time-consuming and expensive.In addition,the excessive demolding force can easily damage patterns since biocompatible hydrogels are ultra-soft or brittle.Here,we presented a novel method for rapid and mass fabrication of cell patterns.High-precision three-dimensional(3D)printing was used to manufacture a mold with a resolution of 2µm,and the gelatin-based hydrogel was cured by thermal–photo-crosslinking so that the low-concentration and low-substitutionrate hydrogel could be demolded successfully.We found that pre-cooling before illumination made gelatin-based hydrogels resilient due to the partial regain of triple-helix structures.With this method,arbitrarily customized hydrogel patterns with a feature size of 6–80µm can be fabricated stably and at low cost.When cardiomyocytes were seeded on ultra-soft hydrogels with parallel groove structures,a consistent and spontaneous beating with 216 beats per minute(BPM)could be observed,approaching the natural beating rate of rat hearts(300 BPM).Overall,this work provides a general scheme for manufacturing cell patterns which has great potential for cell ethology and tissue repair. | Chaofan He Xuechun Chen Yuan Sun Mingjun Xie Kang Yu Jing He Jinwei Lu Qing Gao Jing Nie Yi Wang Yong He | 2022 | Bio-Design and Manufacturing2022，5，4： | 0 |
| 6 | Impact of air pressure variations on electrical vehicle motor insulation显示文摘Variation in air pressure severely affects the insulation of electric vehicle(EV)motors,hence weakening the reliability of EVs for safe operation.Nomex‐polyimide‐Nomex,a typical insulation material for EV motors,was used to investigate the motor insulation performance under different air pressures.The results show that the partial discharge inception voltage is significantly reduced for EV motors operated at lower air pressures,and the probability of partial discharge(PD)occurrence is increased.The macroscopic results reveal that the active area of the PD expands at low pressure,while the non‐corroded ring appears in the centre.Additionally,although the number and amplitude of the PD increase significantly with decrease in air pressure,the active area of the PD expands and electrical stress on the insulation per unit area increases slowly.Therefore,when the pressure decreased from 60 to 40 kPa,the endurance life does not show a significant downward trend.Furthermore,the dielectric constant and loss of the low‐pressure samples significantly change during the ageing process,which further indicates critical degradation of the insulation.The aforementioned investigations reveal that the air pressure at different altitudes has a significant impact on the performance of insulation materials. | Peng Wang Chaofan Yu Shakeel Akram Ziyuan Fan Wenhuan Zhao | 2023 | High Voltage2023，8，5： | 0 |
| 7 | Effects of prebiotics on the fermentation of traditional suancai of Northeast China显示文摘Suancai is a traditional fermented vegetable widely consumed in Northeast China.In this study,different prebiotics were used to improve the quality of suancai.Four prebiotics(inulin(INU),xylooligosaccharide(XO S),galactooligosaccharide(GOS),and stachyose(STA))were shown to reduce the pH value and increase the content of total titratable acidity(TTA)in suancai,while the contents of most organic acids were also increased.The addition of prebiotics had significant effects on the bacterial microbiota during the suancai fermentation process.All prebiotics were shown to contribute to the growth of Lactobacillus.The suancai sample with fructooligosaccharides(FOS)had the highest relative abundance of Lactobacillus.Besides,INU and XOS could increase the abundance of Weissella.To evaluate the quality of suancai fermented with prebiotics,profiles of volatile flavor compounds(VOCs)and free amino acids(FAA)were analyzed.The prebiotics affected the VOCs and FAA profiles via transforming the bacterial microbiota.In addition,the addition of prebiotics also changed the taste profiles of the suancai samples.This study is among the first attempts to reveal the effects of different prebiotics on suancai fermentation,and the findings provide a foundation to develop new ways for improving the quality of suancai. | Mingwei Zhao Xinying Cao Yuzheng Wu Sibo Zou Zhigao Li Xinping Lin Chaofan Ji Liang Dong Sufang Zhang Chenxu Yu Huipeng Liang | 2024 | Food Science and Human Wellness2024，13，3： | 0 |
| 8 | Effects of phosphorylated ovalbumin on the quality of pork myofibrillar protein gel:an insight into gelling and physicochemical properties显示文摘This study aimed to investigate the effects of phosphorylated-ovalbumin(P-OVA)at different concentrations(0.5%and 1.0%)on the gel properties of pork myofibrillar protein(MP).The results showed that the textural properties such as gel hardness,cohesiveness,springiness and chewiness were improved with P-OVA addition at 0.5%.The water holding capacity(up to 75.89%)and gel strength(up to 168.56 g·mm)of MP gel were markedly increased after P-OVA addition.The absolute value of zeta potential reached 13.85 mV and maximum hydrophobicity(15.2μg)resulted from the addition of 0.5%P-OVA.The storage modulus(G’)and loss modulus(G’’)of MP gel were significantly increased from 50°C,and the G’and G’’significantly increased after 1.0%P-OVA addition,evidencing that the cross-linking effect of MP protein gel was enhanced.In addition,the P-OVA addition improved the structure of MP gel protein by reducing theα-helix,while increasing theβ-sheet and the r-value(the ratio between two ultraviolet second-derivative peak-to-trough distances),which further promoted the uniform and compact gel network structure.This work demonstrated that P-OVA is a highly effective modifier that significantly improves the quality of MP gel.From a view of practice,0.5%P-OVA is the optimal addition amount. | Zhihui Yu Yating Gao Meng Wu Chaofan Zhao Xiubin Liu Xiaoyu Zhang Lixin Zhang Yisheng Chen | 2024 | Journal of Future Foods2024，4，2： | 0 |
| 9 | The effect of hierarchical single-crystal ZSM-5 zeolites with different Si/Al ratios on its pore structure and catalytic performance显示文摘Hierarchical single-crystal ZSM-5 zeolites with different Si/Al ratios(Hier-ZSM-5-x,where x=50,100,150 and 200)were synthesized using an ordered mesoporous carbon-silica composite as hard template.Hier-ZSM-5-x exhibits improved mass transport properties,excellent mechanical and hydrothermal stability,and higher catalytic activity than commercial bulk zeolites in the benzyl alcohol self-etherification reaction.Results show that a decrease in the Si/Al ratio in hierarchical single-crystal ZSM-5 zeolites leads to a significant increase in the acidity and the density of micropores,which increases the final catalytic conversion.The effect of porous hierarchy on the diffusion of active sites and the final catalytic activity was also studied by comparing the catalytic conversion after selectively designed poisoned acid sites.These poisoned Hier-ZSM-5-x shows much higher catalytic conversion than the poisoned commercial ZSM-5 zeolite,which indicates that the numerous intracrystalline mesopores significantly reduce the diffusion path of the reactant,leading to the faster diffusion inside the zeolite to contact with the acid sites in the micropores predominating in ZSM-5 zeolites.This study can be extended to develop a series of hierarchical single-crystal zeolites with expected catalytic performance. | Yuexin Hou Xiaoyun Li Minghui Sun Chaofan Li Syed ul Hasnain Bakhtiar Kunhao Lei Shen Yu Zhao Wang Zhiyi Hu Lihua Chen Bao-Lian Su | 2021 | Frontiers of Chemical Science and Engineering2021，15，2： | 0 |
| 10 | Tunable quantum dots in monolithic Fabry-Perot microcavities for high-performance single-photon sources显示文摘Cavity-enhanced single quantum dots(QDs)are the main approach towards ultra-high-performance solid-state quantum light sources for scalable photonic quantum technologies.Nevertheless,harnessing the Purcell effect requires precise spectral and spatial alignment of the QDs’emission with the cavity mode,which is challenging for most cavities.Here we have successfully integrated miniaturized Fabry-Perot microcavities with a piezoelectric actuator,and demonstrated a bright single-photon source derived from a deterministically coupled QD within this microcavity.Leveraging the cavity-membrane structures,we have achieved large spectral tunability via strain tuning.On resonance,a high Purcell factor of~9 is attained.The source delivers single photons with simultaneous high extraction efficiency of 0.58,high purity of 0.956(2)and high indistinguishability of 0.922(4).Together with its compact footprint,our scheme facilitates the scalable integration of indistinguishable quantum light sources on-chip,therefore removing a major barrier to the development of solid-state quantum information platforms based on QDs. | Jiawei Yang Yan Chen Zhixuan Rao Ziyang Zheng Changkun Song Yujie Chen Kaili Xiong Pingxing Chen Chaofan Zhang Wei Wu Ying Yu Siyuan Yu | 2024 | Light(Science & Applications)2024，13，2： | 0 |
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