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| 1 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 2 | Experimental investigations on separation control and flow structure around a circular cylinder with synthetic jet显示文摘Circular cylinder separation control and flow structure influenced by the synthetic jet have been experimentally investigated in a water channel. The synthetic jet is- sues from a slot and ejects toward upstream from the front stagnation point of the cylinder. It has been found that, similar to the traditional synthetic jet which is po- sitioned near the separation point or inside the separation region, the present synthetic jet arrangement constitutes an efficient way to control flow separation of the circular cylinder, but with a different control mechanism. The present synthetic jet leads to an upstream displacement of the front stagnation point and the forma- tion of a vortex pair near both sides of the exit orifice. When ReU based on the synthetic jet average exit orifice velocity is about lower than 43, a closed envelope forms in front of the windward side of the cylinder during the blowing cycle of syn- thetic jet, which acts as an apparent modification for the cylinder configuration. When ReU is high enough, an open envelope forms upstream of the cylinder, and the flow around the cylinder becomes much energetic. Thus, regardless of ReU, the present synthetic jet can improve separation for flow around a circular cylinder. With regard to the leeward side, as ReU increases, the flow separation region be- hind the cylinder gradually disappears. The flow over cylinder may be fully attached when the open envelope forms upstream of the cylinder and ReU is greater than 344. Then, the flow past the cylinder will converge near the back stagnation point of the cylinder, where a new vortex pair shedding periodically is generated due to the high shear layer. | WANG JinJun FENG LiHao XU ChaoJun | 2007 | Science China(Technological Sciences)2007，50，5： | 9 |
| 3 | Abnormal perturbations in the ionospheric F2 region before Wenchuan earthquake on 12 May 2008显示文摘On 12 May 2008 at 14:28 BJT, a great earthquake (M=8.0) occurred in Wenchuan (31.00°N, 103.40°E), China. The hourly foF2 from 5 to 12 May have been analyzed over four ionospheric observatories: Kunming (25.00°N, 102.70°E), Chongqing (29.50°N, 106.40°E), Lhasa (29.63°N, 91.17°E), and Lanzhou (36.07°N, 103.87°E). The results show that foF2 were notably abnormal from upper bound (the maximum abnormality up to 65% at 17:00 BJT) and lasted about 3 h on 9 May over Chongqing station. Moreover, there were obvious perturbations of foF2 on the same day over other stations except Lhasa. Taking into account that the solar activity and geomagnetic activity were very quiet during this period, we can conclude that the observed positive ionospheric perturbations were likely associated with the imminent earthquake. | Xu Tong Hu YanLi Wu Jian Wu ZhenSen Suo YuCheng Feng Jian Huang ChaoJun | 2010 | Science China Earth Sciences2010，53，11： | 4 |
| 4 | Synthesis of cyclic peptide reniochalistatin E and conformational isomers显示文摘Here, we report a convenient and efficient synthesis strategy for the total synthesis of cyclic peptide reniochalistatin E and its conformational isomers with 32% overall yield. We found the linear peptide precursor without side chain gave better cyclization yield. | Huiyun Luo Hongli Yin Chaojun Tang Ping Wang Feng Liang | 2018 | Chinese Chemical Letters2018，29，7： | 1 |
| 5 | Scale Breeding and Reproduction Technique of Ficus tikoua Bur.Container Seedlings显示文摘Based on the principle of asexual reproduction,a kind of scale breeding and reproduction technique of Ficus tikoua Bur.container seedlings was explored by using the characteristics of strong adaptability to the environment and fast growth and reproduction.Using non-woven bag as a breeding container for seedlings,the scale breeding and reproduction technique of F.tikoua container seedlings was summarized through the important links of seedling bed construction,seedling collection,soil configuration,container selection,cutting cultivation,field management,and disease and pest control.This technique can achieve differential,massive and sustainable efficient breeding and reproduction of F.tikoua seedlings in a short time. | Tinghong TAN Fan GAO Yang XIAO Mingxing DAI Shunping BAI Shimei LIAO Chaojun FENG Chunfang WU | 2023 | Plant Diseases and Pests2023，14，5： | 0 |
| 6 | The Disillusionment of the National Ideal Image of China During the Reign of the Qing Dynasty显示文摘The author analyzed the subjective factors of the gradual disillusionment of China’s national image, which can be summed up as the increasingly conservative ruling policy of the Qing Dynasty, the increasingly extravagant and corrupt feudal ruling groups, the increasing diplomatic strategy of seclusion and the increasingly imprisoned ruling ideology. The root cause lay in the decline of agricultural civilization and the rise of industrial civilization. The seclusion of the Qing Dynasty caused China to miss the wave of industrial civilization development, and finally led to the reversal of the image of the West and China. | DUAN Feng LI Chaojun | 2019 | Journal of Landscape Research2019，11，6： | 0 |
| 7 | The Decline of Image of China Under the Background of Rites Controversy in Qing Dynasty显示文摘At the turn of the 18th-19th century,in the process of developing missionary business in China,there was a debate about the nature of traditional Chinese sacrificial rites among missionaries,that is,whether the traditional rites of Confucius and Christianity were consistent.With the intervention of the Vatican and the Qing Dynasty,the Chinese rites controversy evolved into the dispute over Chinese imperial power and Roman religious imperial power.The missionary career in China also experienced the transformation from the toleration order,exclusion order and the ticket receiving order to the prohibition order.The sharp opposition between Chinese imperial power and Roman religious imperial power led to the desperate situation of Christian career in China.The missionaries naturally vented their dissatisfaction with China,the good image of China gradually collapsed,and the western image of China began to decline rapidly. | DUAN Feng LI Chaojun | 2020 | Journal of Landscape Research2020，12，1： | 0 |
| 8 | Lipocalin-2-Mediated Insufficient Oligodendrocyte Progenitor Cell Remyelination for White Matter Injury After Subarachnoid Hemorrhage via SCL22A17 Receptor/Early Growth Response Protein 1 Signaling显示文摘Insufficient remyelination due to impaired oligodendrocyte precursor cell(OPC)differentiation and maturation is strongly associated with irreversible white matter injury(WMI)and neurological deficits.We analyzed whole transcriptome expression to elucidate the potential role and underlying mechanism of action of lipocalin-2(LCN2)in OPC differentiation and WMI and identified the receptor SCL22A17 and downstream transcription factor early growth response protein 1(EGR1)as the key signals contributing to LCN2-mediated insufficient OPC remyelination.In LCN-knockdown and OPC EGR1 conditional-knockout mice,we discovered enhanced OPC differentiation in developing and injured white matter(WM);consistent with this,the specific inactivation of LCN2/SCl22A17/EGR1 signaling promoted remyelination and neurological recovery in both atypical,acute WMI due to subarachnoid hemorrhage and typical,chronic WMI due to multiple sclerosis.This potentially represents a novel strategy to enhance differentiation and remyelination in patients with white matter injury. | Qiang Li Xufang Ru Yang Yang Hengli Zhao Jie Qu Weixiang Chen Pengyu Pan Huaizhen Ruan Chaojun Li Yujie Chen Hua Feng | 2022 | Neuroscience Bulletin2022，38，12： | 0 |
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