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    题名 作者 年代 出处 被引量
1Inactivation of TFEB and NF-kB by marchantin M alleviates the chemotherapy-driven pro-tumorigenic senescent secretion显示文摘It is critical to regulate the senescence-associated secretory phenotype(SASP) due to its effect on promoting malignant phenotypes and limiting the efficiency of cancer therapy. In this study, we demonstrated that marchantin M(Mar-M, a naturally occurring bisbibenzyl) suppressed proinflammatory SASP components which were elevated in chemotherapy-resistant cells. Mar-M treatment attenuated the pro-tumorigenic effects of SASP and enhanced survival in drug-resistant mouse models.No toxicity was detected on normal fibroblast cells or in animals following this treatment. Inactivation of transcription factor EB(TFEB) and nuclear factor-k B(NF-k B) by Mar-M significantly accounted for its suppression on the components of SASP. Furthermore, inhibition of SASP by Mar-M contributed to a synergistic effect during co-treatment with doxorubicin to lower toxicity and enhance antitumor efficacy. Thus, chemotherapy-driven pro-inflammatory activity, seen to contribute to drug-resistance, is an important target for Mar-M. By decreasing SASP, Mar-M may be a potential approach to overcome tumor malignancy.Huanmin Niu Lilin Qian Bin Sun Wenjian Liu Fang Wang Qian Wang Xiaotian Ji Yanhai Luo Effat Un Nesa Hongxiang Lou Huiqing Yuan 2019Acta Pharmaceutica Sinica B2019,9,5:4
2A computational study into the effect of exhaust gas recycling on homogeneous charge compression ignition combustion in internal combustion engines fuelled with methane 显示文摘Chen Rui Milovanovic Nesa 2002International Journal of Thermal Sciences2002,,41:1
3Endopyelotomy:prognostic factors and patient selection显示文摘Van Cangh P J Nesa S 1998Urol Clin North Am1998,25,2:1
4Interleukin-2 induces poxide production by primed norm odense eosinophils of patients with asthma显示文摘 Tassinari P Aldrey O 2003Allergy Asthma Proc2003,24,1:1
5Underground EHV systen in Copenhagen 显示文摘Per Christensen Ture Roes NESA A/s Denmark 2000Transmission & Distribution World2000,52,6:1
6Testicular torsion after previous orchidopexy for unde scended testis显示文摘Nesa S 1998Acta Urol Belg1998,66,3:1
7A computational study into the effect of exhaust gas recycling on homogeneous charge compression ignition combustion in internal combustion engines fuelled with methane 显示文摘Chen Rui Milovanovic Nesa 2002International Journal of Thermal Sciences2002,41,:1
8Vessels around the ureteropelvic junction:significance and imaging by conventional ra-diology显示文摘Van Cangh PJ Nesa S Galeon M 1996J Endourol1996,10,10:1
9A Computational Study into the Effect of Exhaust Gas Recycling on Homogeneous Charge Compression Ignition Combustion in Internal Combustion Engines Fuelled with Methane显示文摘Chen Rui Milovanovic Nesa 2002Internation Journal of Thermal Sciences2002,41,9:1
10A computational study into the effect of exhaust gas recycling on homogeneous charge compression ignition combustion in internal combustion engines fuelled with methane 显示文摘Chen Rui Milovanovic Nesa 2002International Journal of ThermalSciences2002,41,:1
11Under- ground EHV system in Copenhagen 显示文摘Per Christensen Ture Roes NESA A \ s Denmarl 2000Transmission & Dis- tribution World2000,52,6:1
12Comparative study between gas sensors arrays device, sensory evaluation and GC/MS analysis for QC in automotive industry 显示文摘Garrigues S Talou T Nesa D 2004Sensors and Actuators B2004,103,:1
13A Computational Study into the Effect of Exhaust Gas Recycling on Homogeneous Charge Compression Ignition Combustion in Internal Combustion Engines Fuelled with Methane 显示文摘Chen Rui Nesa Milovanovic 2002International Journal of Thermal Sciences2002,41,:1
14Energy efficient data transmission in automatic irrigation system using wireless sensor networks显示文摘M. Nesa Sudha M.L. Valarmathi Anni Susan Babu 2011Computers and Electronics in Agriculture2011,,2:1
15Interleukin-2 induces poxide production by primed normodense eosinophils of patients with asthma显示文摘Nesa A Tassinari P Aldrey O 2003Allergy Asthma Proc2003,24,1:1
16A Computational Study into the Effect of Exhaust Gas Recycling on Homogeneous Charge Compression Ignition Combustion in Internal Combustion Engines Fuelled with Methane 显示文摘Chen Rui Nesa Milovanovic 2002International Journal of Thermal Sciences2002,41,9:1
17A computational study into the effect of exhaust gas recycling on homogeneous charge compression ignition combustion in intemal com- bustion engines fuelled with methane 显示文摘Chen Rui Nesa Milovanovic 2002International Journal of ThermalScience2002,4,9:1
18Interleukin-2 induces poxide production by primed norm odense eosinophils of patients with asthma显示文摘 Tassinari P Aldrey O 2003Allergy Asthma Proc2003,24,1:1
19Route and survey processing of topographical memory during navigation显示文摘Latini-Corazzini L Nesa MP Ceccaldi M 2010Psychol Res2010,74,:1
20A computational study into the effect of exhaust gas recycling on homogeneous eharge compression ignition combustion in internal combustion engines fuelled with methane显示文摘Chen Rui Nesa Milovanovic 2002International Journal of Thermal Sciences2002,41,9:1
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