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| 1 | Functional analysis of transcriptional regulation of herpes simplex virus type 1 tegument protein VP22显示文摘The herpes simplex virus type 1 (HSV-1) tegument proteins have important functions in the viral repli- cation process. In order to investigate the role of the HSV-1 tegument protein VP22 in viral replication, its transcriptional regulation of viral promoters was investigated using the chloramphenicol acetyl- transferase (CAT) assay. The results indicate that VP22 exerts a dose-dependent transcriptional in- hibitory effect on the HSV-1 α4, TK, and gC gene promoters. VP22 had the capacity to repress tran- scriptional activation of promoters via different viral transcription regulatory factors such as VP16 and ICP0, as evidenced by the specific repression of the TK and gC gene promoters by ICP0. In addition, VP22 was capable of inhibiting the promotion of ICP0 transcriptional activation in the presence of HAT PCAF, which is even more remarkable than the VP22 repression of ICP0 transcriptional activation. Fi- nally, the transcriptional inhibitory effect of VP22 on other viral promoters was demonstrated by the analysis of β-galactosidase activities in internal controls. | YU Xian1,2, LI WeiZhong1, LIU LongDing1, CHE YanChun1, CUN Wei1, WU WenJuan1, HE ChunYan1, SHAO CongWen1 & LI QiHan1 1 Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China 2 Institute of Materia Medica, North Sichuan Medical College, Nanchong 637007, China | 2008 | Science China(Life Sciences)2008，51，11： | 4 |
| 2 | A transient method for measuring the gas volume fraction in a mixed gas-liquid flow using acoustic resonance spectroscopy显示文摘In this paper, the feasibility of measuring the gas volume fraction in a mixed gas-liquid flow by using an acoustic resonant spectroscopy (ARS) method in a transient way is studied theoretically and experimentally. Firstly, the effects of sizes and locations of a single air bubble in a cylindrical cavity with two open ends on resonant frequencies are investigated numerically. Then, a transient measurement system for ARS is established, and the trends of the resonant frequencies (RFs) and resonant amplitudes (RAs) in the cylindrical cavity with gas flux inside are investigated experimentally. The measurement results by the proposed transient method are compared with those by steady-state ones and numerical ones. The numerical results show that the RFs of the cavity are highly sensitive to the volume of the single air bubble. A tiny bubble volume perturbation may cause a prominent RF shift even though the volume of the air bubble is smaller than 0.1% of that of the cavity. When the small air bubble moves, the RF shift will change and reach its maximum value as it is located at the middle of the cavity. As the gas volume fraction of the two-phase flow is low, both the RFs and RAs from the measurement results decrease dramatically with the increasing gas volume, and this decreasing trend gradually becomes even as the gas volume fraction increases further. These experimental results agree with the theoretical ones qualitatively. In addition, the transient method for ARS is more suitable for measuring the gas volume fraction with randomness and instantaneity than the steady-state one, because the latter could not reflect the random and instant characteristics of the mixed fluid due to the time consumption for frequency sweeping. This study will play a very important role in the quantitative measurement of the gas volume fraction of multiphase flows. | CHEN DeHua1*, WANG XiuMing1, CHE ChengXuan1, CONG JianSheng1,2, XU DeLong2 & WANG XiaoMin1 1 State Key Laboratory of Acoustics, Institute of Acoustics, Chinese Academy of Sciences, Beijing 100190, China 2 Department of Geophysics, Northeast Petroleum University, Daqing 163318, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，8： | 2 |
| 3 | Evaluation of postural stability in the elderly with stroke显示文摘 | Corriveau H Hébert R Ra(1)che M | 2004 | Arch Phys Med Rehabil2004，85，7： | 1 |
| 4 | Modelling Immune System:Principles,Models,Analysis and Perspectives显示文摘The biological immune system is a complex adaptive system.There are lots of benefits for building the model of theimmune system.For biological researchers,they can test some hypotheses about the infection process or simulate the responsesof some drugs.For computer researchers,they can build distributed,robust and fault tolerant networks inspired by the functionsof the immune system.This paper provides a comprehensive survey of the literatures on modelling the immune system.Fromthe methodology perspective,the paper compares and analyzes the existing approaches and models,and also demonstrates thefocusing research effort on the future immune models in the next few years. | Xiang-hua Li~1, Zheng-xuan Wang~1, Tian-yang Lu~2, Xiang-jiu Che~11. College of Computer Science and Technology, Jilin University, Changchun 130012, P. R. China2. College of Computer Science and Technology, Harbin Engineering University, Harbin 150001, P. R. China | 2009 | Journal of Bionic Engineering2009，6，1： | 1 |
| 5 | Anemia and Inflammation in ST-Segment Elevation Myocardial Infarction 显示文摘 | Zhang E 1 Li Z Che J | 2015 | Am J Med Sci2015，349，6： | 1 |
| 6 | Serum autoantibodies against human oxidized low-density lipoproteins are inversely associated with severity of coronary stenotic lesions calculated by Gensini score 显示文摘 | Che 1 Li G Wang W | 2011 | Cardiol 12011，18，4： | 1 |
| 7 | Time-Resolved Photoluminescence Spectra of Porous Si显示文摘Time-ResolvedPhotoluminescenceSpectraofPorousSiFEIHao-sheng,HANLi,CHEYan-long,NIERui-juanandLITie-jin(DeparrmentofPhysicsandD... | FEI Hao-sheng HAN Li CHE Yan-long NIE Rui-juan and LI Tie-jin(Deparrment of Physics and Deparrment of Chemistry ,Jilin University , Changchun , 1 30023 ) | 1995 | Chemical Research in Chinese Universities1995，11，1： | 0 |
| 8 | RHEOLOGY OF GAS-FLUIDIZED BED显示文摘Coal dry beneficiation with fluidized beds belongs to dry dense m ediu m concentration . Therheology is im portant for studying the behavior of an object settling in gas fluidized beds . Inthis paper , The viscosity of fluidized beds w as measured using falling spheres . The rheologi cal characteristics of fluidized beds can be described with Bingha m fluid m odel . The efficientviscosity of fluidized beds can be calculated and plastic viscosity and yield stress of fluidizedbed can be obtained by linearly regressing experi mental data . The calculated results are veryagreeable with the experim ental data . | L. B. Wei1) and M. Y. Zhao2)1) Department of Chemical and Environmental Engineering , China University of Mining and Technology , Beijing100083 , China2) Department of Energy Utilization and Che mical Engineering , China University of | 1999 | Acta Metallurgica Sinica(English Letters)1999，12，5： | 0 |
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