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| 1 | Efficacy and safety of high-dose esomeprazole–amoxicillin dual therapy for Helicobacter pylori rescue treatment:a multicenter,prospective,randomized,controlled trial显示文摘Background:High-dose dual therapy(HDDT)with proton pump inhibitors(PPIs)and amoxicillin has attracted widespread attention due to its favorable efficacy in eradicating Helicobacter pylori(H.pylori).This study aimed to compare the efficacy and safety of high-dose PPI-amoxicillin dual therapy and bismuth-containing quadruple therapy for H.pylori rescue treatment.Methods:This was a prospective,randomized,multicenter,non-inferiority trial.Patients recruited from eight centers who had failed previous treatment were randomly(1:1)allocated to two eradication groups:HDDT(esomeprazole 40 mg and amoxicillin 1000 mg three times daily;theHDDTgroup)and bismuth-containing quadruple therapy(esomeprazole 40 mg,bismuth potassium citrate 220 mg,and furazolidone 100 mg twice daily,combined with tetracycline 500 mg three times daily;the tetracycline,furazolidone,esomeprazole,and bismuth[TFEB]group)for 14 days.The primary endpoint was the H.pylori eradication rate.The secondary endpoints were adverse effects,symptom improvement rates,and patient compliance.Results:A total of 658 patients who met the criteria were enrolled in this study.The HDDT group achieved eradication rates of 75.4%(248/329),81.0%(248/306),and 81.3%(248/305)asdetermined by the intention-to-treat(ITT),modified intention-totreat(MITT),and per-protocol(PP)analyses,respectively.The eradication rates were similar to those in the TFEB group:78.1%(257/329),84.2%(257/305),and 85.1%(257/302).The lower 95%confidence interval boundary(9.19%in the ITT analysis,9.21%in the MITT analysis,and9.73%in the PP analysis)was greater than the predefined non-inferiority margin of10%,establishing a non-inferiority of the HDDT group vs.the TFEB group.The incidence of adverse events in the HDDT group was significantly lower than that in the TFEB group(11.1%vs.26.8%,P<0.001).Symptom improvement rates and patients’compliance were similar between the two groups.Conclusions:Fourteen-day HDDT is non-inferior to bismuth-containing quadruple therapy,with fewer adverse effects and good treatment compliance,suggesting HDDT as an alternative for H.pylori rescue treatment in the local region.Trial registration:Clinicaltrials.gov,NCT04678492. | Hanxin Bi Xingxing Chen Yuxin Chen Xin Zhao Shasha Wang Jiehong Wang Ting Lyu Shuang Han Tao Lin Mingquan Li Donghong Yuan Junye Liu Yongquan Shi | 2022 | Chinese Medical Journal2022，，14： | 3 |
| 2 | Changes of the Quinolones Resistance to Gram-positive Cocci Isolated during the Past 8 Years in the First Bethune Hospital显示文摘 | Jiancheng Xu Qihui Chen Hanxin Yao | | 0，，33： | 1 |
| 3 | An adaptive morlet wavelet filter for time-of-flight estimation in ultrasonic damage assessment显示文摘 | Chen Hanxin ZUO MingJ WANG Xiaodong | 2010 | Measurement2010，43，4： | 1 |
| 4 | network No:显示文摘 | Hanxin Chen Ling Tu reduction method based Kui Sun on RBF | 2014 | Key Engineering Materials2014，，589590： | 1 |
| 5 | Fault identification of gearbox degradation with optimized wavelet neural network 显示文摘 | CHEN Hanxin LU YanJun TU Ling | 2013 | Shock and Vibration2013，20，2： | 1 |
| 6 | Vibration analysis with lift- ing scheme and generalized cross validation in fault diagnosis of water hydraulic system 显示文摘 | Chen Hanxin Chua P S K Lim G H | 2007 | Journal of Sound and Vibration2007，301，35： | 1 |
| 7 | Fish-Eye Image Distortion Correction Based on Adaptive Partition Fitting显示文摘The acquisition of images with a fish-eye lens can cause serious image distortion because of the short focal length of the lens.As a result,it is difficult to use the obtained image information.To make use of the effective information in the image,these distorted imagesmust first be corrected into the perspective of projection images in accordance with the human eye’s observation abilities.To solve this problem,this study presents an adaptive classification fitting method for fish-eye image correction.The degree of distortion in the image is represented by the difference value of the distances fromthe distorted point and undistorted point to the center of the image.The target points selected in the image are classified by the difference value.In the areas classified by different distortion differences,different parameter curves were used for fitting and correction.The algorithm was verified through experiments.The results showed that this method has a substantial correction effect on fish-eye images taken by different fish-eye lenses. | Yibin He Wenhao Xiong Hanxin Chen Yuchen Chen Qiaosen Dai Panpan Tuand Gaorui Hu | 2021 | Computer Modeling in Engineering & Sciences2021，，1： | 1 |
| 8 | Hypersonic Shock Wave/Boundary Layer Interactions by a Third-Order Optimized Symmetric WENO Scheme显示文摘A novel third-order optimized symmetric weighted essentially non-oscillatory(WENO-OS3)scheme is used to simulate the hypersonic shock wave/boundary layer interactions.Firstly,the scheme is presented with the achievement of low dissipation in smooth region and robust shock-capturing capabilities in discontinuities.The Maxwell slip boundary conditions are employed to consider the rarefied effect near the surface.Secondly,several validating tests are given to show the good resolution of the WENO-OS3 scheme and the feasibility of the Maxwell slip boundary conditions.Finally,hypersonic flows around the hollow cylinder truncated flare(HCTF)and the25°/55°sharp double cone are studied.Discussions are made on the characteristics of the hypersonic shock wave/boundary layer interactions with and without the consideration of the slip effect.The results indicate that the scheme has a good capability in predicting heat transfer with a high resolution for describing fluid structures.With the slip boundary conditions,the separation region at the corner is smaller and the prediction is more accurate than that with no-slip boundary conditions. | Li Chen Guo Qilong Li Qin Zhang Hanxin | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，5： | 1 |
| 9 | Clinical features of multiple myeloma patients with isolated extramedullary relapse显示文摘This study sought to analyze the clinical features and prognosis of multiple myeloma with isolated extramedullary relapse and with the absence of systemic progression.The clinical features and outcome were retrospectively analyzed in six multiple myeloma patients.These patients had secretory multiple myeloma at diagnosis.When relapsed,the dissociation between medullary and extramedullary response was detected.The serum or urine monoclonal component was extremely low or absent.The plasma cells in bone marrow were <5%.All patients received new targeted therapies(thalidomide or bortezomib) before extramedullary relapse.It is difficult to achieve second remission for them.Even in those showing response,the duration of response was extremely short.The median of overall survival from diagnosis and from extramedullary relapse was 19 months and 6 months,respectively.The overall survival was significantly shorter compared to the patients without extramedullary involvement(84 months,P= 0.001).These patients exhibited a special and rare relapse pattern.Patients with this relapse pattern were resistant to current therapies,including novel targeted agents and associated with poor prognosis. | Xiaoyan Qu Lijuan Chen Tian Tian Limin Duan Ruinan Lu Hua Lu Hanxin Wu Jianyong Li | 2018 | The Journal of Biomedical Research2018，32，4： | 0 |
| 10 | Inverse Model Control for a Quad-rotor Aircraft Using TS-fuzzy Support Vector Regression显示文摘An inverse model control based on TS-fuzzy support vector regression( TS-fuzzy SVR) for a quadrotor aircraft is developed. The TS-kernel is the product of linear combination of input and a cluster of output corresponding to a cluster of TS-type fuzzy rules. The output of TS-fuzzy SVR is a linear weighted sum of the TSkernels. The dynamical model of the quad-rotor aircraft is derived. A new control scheme combined with TSfuzzy SVR inverse model control and PID control is presented so that the TS-fuzzy SVR inverse model control enhances capabilities of disturbance rejection and the robustness while the PID control enhances fast responsiveness and reliability of the system. Simulation results show the capabilities of the developed control for the attitude system of quad-rotor aircraft. | Zhiyu Li Hanxin Chen Congqing Wang Kaijia Xue | 2017 | Journal of Harbin Institute of Technology(New Series)2017，24，6： | 0 |
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