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| 1 | DNA and histone methylation in gastric carcinogenesis显示文摘Epigenetic alterations contribute significantly to the development and progression of gastric cancer,one of the leading causes of cancer death worldwide.Epigenetics refers to the number of modifications of the chromatin structure that affect gene expression without altering the primary sequence of DNA,and these changes lead to transcriptional activation or silencing of the gene.Over the years,the study of epigenetic processes has increased,and novel therapeutic approaches that target DNA methylation and histone modifications have emerged.A greater understanding of epigenetics and the therapeutic potential of manipulating these processes is necessary for gastric cancer treatment.Here,we review recent research on the effects of aberrant DNA and histone methylation on the onset and progression of gastric tumors and the development of compounds that target enzymes that regulate the epigenome. | Danielle Queiroz Calcagno Carolina Oliveira Gigek Elizabeth Suchi Chen Rommel Rodriguez Burbano Marília de Arruda Cardoso Smith | 2013 | World Journal of Gastroenterology2013，19，8： | 14 |
| 2 | Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma显示文摘AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways. | Danielle Queiroz Calcagno Mariana Ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki Paulo Pimentel Assumpcao Mario Henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia Valéria Pitombeira Ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano | 2006 | World Journal of Gastroenterology2006，12，38： | 9 |
| 3 | Self-assembled PEG-b-PDPA-b-PGEM copolymer nanoparticles as protein antigen delivery vehicles to dendritic cells:preparation,characterization and cellular uptake显示文摘Antigen uptake by dendritic cells(DCs)is a key step for initiating antigen-specific T cell immunity.In the present study,novel synthetic polymeric nanoparticles were prepared as antigen delivery vehicles to improve the antigen uptake by DCs.Well-defined cationic and acid-responsive copolymers,monomethoxy poly(ethylene glycol)-block-poly(2-(diisopropyl amino)ethyl methacrylate)-block-poly(2-(guanidyl)ethyl methacrylate)(mPEG-b-PDPA-b-PGEM,PEDG)were synthesized by reversible addition-fragmentation chain transfer polymerization of 2-(diisopropylamino)ethyl methacrylate and N-(tert-butoxycarbonyl)amino ethyl methacrylate monomers,followed by deprotection of tert-butyl protective groups and guanidinylation of obtained primary amines.1H NMR,13C NMR and GPC results indicated the successful synthesis of well-defined PEDG copolymers.PEDG copolymers could self-assemble into nanoparticles in aqueous solution,which were of cationic surface charges and showed acid-triggered disassembly contributed by PGEM and PDPA moieties,respectively.Significantly,PEDG nanoparticles could effectively condense with negatively charged model antigen ovalbumin(OVA)to form OVA/PEDG nanoparticle formulations with no influence on its secondary and tertiary structures demonstrating by far-UV circular dichroism and UV-vis spectra.In vitro antigen cellular uptake by bone marrow DCs(BMDCs)indicated using PEDG nanoparticles as antigen delivery vehicles could significantly improve the antigen uptake efficiency of OVA compared with free OVA or the commercialized Alum adjuvant.Moreover,as the surface cationic charges of OVA/PEDG nanoparticle formulations reduced,the uptake efficiency decreased correspondingly.Collectively,our work suggests that guanidinylated,cationic and acid-responsive PEDG nanoparticles represent a new kind of promising antigen delivery vehicle to DCs and hold great potential to serve as immunoadjuvants in the development of vaccines. | Pan Li Junhui Zhou Pingsheng Huang Chuangnian Zhang Weiwei Wang Chen Lia Deling Kong | 2017 | Regenerative Biomaterials2017，4，1： | 2 |
| 4 | Lymphatic vessel density as pre- dictive marker for the local recurrence of rectal cancer 显示文摘 | Chen WR Chen MG Lia ZQ | 2009 | Dis Colon Rectum2009，52，3： | 1 |
| 5 | Synchronization in general complex dynamical networks with coupling delays显示文摘 | LIA Chunguang CHEN Guanrong | 2004 | Phys A2004，343，： | 1 |
| 6 | Inactivation of Saccharomyces cerevisiae by supercritical and subcritical carbon dioxide显示文摘 | Lia H M Yang Z Y Chen L F | 1992 | Biotechnology Progress1992，8，5： | 1 |
| 7 | The extraeellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development显示文摘 | Lia Z Chen S Boyle S | 2013 | Dev Cell2013，25，6： | 1 |
| 8 | Acid-base enrichment enhances anaerobic hydrogen production process显示文摘 | CHEN Chinchao LIN Chiuyue LIA Mincheng | 2002 | Applied Microbiology Biotechnology2002，58，2： | 1 |
| 9 | Functional Impairment of Dendritic Cells Caused by Murine Hepatocellular Carcinoma显示文摘 | Wei-Chen Lee Yang-Jen Chiang Hui-Chuan Wang Min-Ru Wang Shin-Ru Lia Miin-Fu Chen | 2004 | Journal of Clinical Immunology2004，，2： | 1 |
| 10 | Synthesis of CeO2nanoparticles by mechanochemical processing and the inhibiting action of NaCl on particle agglomeration显示文摘 | Lia Y X Chen W F Zhou X Z | 2005 | Materials Letters2005，59，： | 1 |
| 11 | Genetic diversity and potential for pro-motion of plant growth detected in nodule endophytic bacteria of soy-bean grown in Heilongjiang province of China显示文摘 | Lia J H Wang E T Chen W F | 2008 | Soil Biology and Bio-chemistry^2008，40，： | 1 |
| 12 | An extraction of the natural frequencies and mode shapes of marine risers by the method of differential transformation显示文摘 | Yanfei Chen Y H Chai Xin Lia | 2009 | Computers and Structures2009，87，21： | 1 |
| 13 | Review of CO2 absorption using chemical solvents in hollow fiber membrane contactors显示文摘 | LIA L-L CHEN B-H | 2005 | Sep Purif Technol2005，41，2： | 1 |
| 14 | Overexpressed CacyBWSIP leads to the suppression of growth in renal cell carcinoma 显示文摘 | Sun S Ning X Liu J Lia L Chen Y Han S Zhang Y Liang J Wu K Fan D | 2007 | Biochem Biophys Res Commun2007，356，： | 1 |
| 15 | Nonlinear elastoplastic dynamic analysis of single-layer reticulated shells subjected to earthquake excitation显示文摘 | LIA Q S CHEN J M | 2003 | Computers and Structures2003，11，81： | 1 |
| 16 | Determination of the dividing strength and its relation to the concrete strength in lightweight aggregate concrete 显示文摘 | CHEN H J YEN T LIA T P HUANG Y L | 1999 | Cement and Concrete Composites1999，21，1： | 1 |
| 17 | Metabonomics study on the biochemical profiles of a hydmeortisone-induced animal显示文摘 | Chen M Zhau L lia W | 2005 | J Proteome Res2005，4，6： | 1 |
| 18 | Quantification of cerebral blood flow by bolus tracking and artery spin tagging methods显示文摘 | Lia T Q Guang Chen Z Ostergaard L | 2000 | Magnetic Resonance Imaging2000，18，5： | 1 |
| 19 | Study of flowerlike Ce02 microspheres used as catalyst supports for CO oxidation reaction 显示文摘 | Sun C W Lia H Chen L Q | 2007 | J Phy Chem Solid2007，68，： | 1 |
| 20 | Nonlinear elastoplastic dynamic analysis of single-layer reticulated shells subjected to earthquake excitation显示文摘 | Lia Q S Chen J M | 2003 | Computers and Structures2003，，81： | 1 |
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