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| 1 | Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis显示文摘 | Jian-ping LI Yan GAO Shi-feng CHU Zhao ZHANG Cong-yuan XIA Zheng MOU Xiu-yun SONG Wen-bin HE Xiao-feng GUO Nai-hong CHEN | 2014 | Acta Pharmacologica Sinica2014，35，8： | 31 |
| 2 | Using iron fertilizer to control Cd accumulation in rice plants: A new promising technology显示文摘Effects of two kinds of iron fertilizer, FeSO4 and EDTA·Na2Fe were studied on cadmium accumulation in rice plants with two rice genotypes, Zhongzao 22 and Zhongjiazao 02, with soil culture systems. The results showed that application of iron fertilizers could hardly make adverse effects on plant growth and rice grain yield. Soil application of EDTA·Na2Fe significantly reduced the Cd accumulation in rice roots, shoots and rice grain. Cd concentration in white rice of both rice genotypes in the treatment of soil application of EDTA·Na2Fe was much lower than 0.2 mg/kg, the maximal Cd permission concentra- tion in cereal crop foods in State standard. However, soil application of FeSO4 or foliar application of FeSO4 or EDTA·Na2Fe resulted in the significant increase of Cd accumulation in rice plants including rice grain compared with the control. The results also showed iron fertilizers increased the concentra- tion of iron, copper and manganese element in rice grain and also affected zinc concentration in plants. It may be a new promising way to regulate Cd accumulation in rice grain in rice production through soil application of EDTA·Na2Fe fertilizers to maintain higher content of available iron and ferrous iron in soils. | SHAO GuoSheng, CHEN MingXue, WANG DanYing, XU ChunMei, MOU RenXiang, CAO ZhaoYun & ZHANG XiuFu China National Rice Research Institute, Hangzhou 31006, China | 2008 | Science China(Life Sciences)2008，51，3： | 28 |
| 3 | Laparoscopic vs open D2 gastrectomy for locally advanced gastric cancer: A meta-analysis显示文摘AIM:To conduct a meta-analysis comparing laparoscopic(LGD2)and open D2 gastrectomies(OGD2)for the treatment of advanced gastric cancer(AGC).METHODS:Randomized controlled trials(RCTs)and non-RCTs comparing LGD2 with OGD2 for AGC treatment,published between 1 January 2000 and 12January 2013,were identified in the Pub Med,Embase,and Cochrane Library databases.Primary endpoints included operative outcomes(operative time,intraoperative blood loss,and conversion rate),postoperative outcomes(postoperative analgesic consumption,time to first ambulation,time to first flatus,time to first oralintake,postoperative hospital stay length,postoperative morbidity,incidence of reoperation,and postoperative mortality),and oncologic outcomes(the number of lymph nodes harvested,tumor recurrence and metastasis,disease-free rates,and overall survival rates).The Cochrane Collaboration tools and the modified Newcastle-Ottawa scale were used to assess the quality and risk of bias of RCTs and non-RCTs in the study.Subgroup analyses were conducted to explore the incidence rate of various postoperative morbidities as well as recurrence and metastasis patterns.A Begg’s test was used to evaluate the publication bias.RESULTS:One RCT and 13 non-RCTs totaling 2596patients were included in the meta-analysis.LGD2 in comparison to OGD2 showed lower intraoperative blood loss[weighted mean difference(WMD)=-137.87 m L,95%CI:-164.41--111.33;P<0.01],lower analgesic consumption(WMD=-1.94,95%CI:-2.50--1.38;P<0.01),shorter times to first ambulation(WMD=-1.03d,95%CI:-1.90--0.16;P<0.05),flatus(WMD=-0.98d,95%CI:-1.30--0.66;P<0.01),and oral intake(WMD=-0.85 d,95%CI:-1.67--0.03;P<0.05),shorter hospitalization(WMD=-3.08 d,95%CI:-4.38--1.78;P<0.01),and lower postoperative morbidity(odds ratio=0.78,95%CI:0.61-0.99;P<0.05).No significant differences were observed between LGD2 and OGD2 for the following criteria:reoperation incidence,postoperative mortality,number of harvested lymph nodes,tumor recurrence/metastasis,or three-or five-year diseasefree and overall survival rates.However,LGD2 had longer operative times(WMD=57.06 min,95%CI:41.87-72.25;P<0.01).CONCLUSION:Although a technically demanding and time-consuming procedure,LGD2 may be safe and effective,and offer some advantages over OGD2 for treatment of locally AGC. | Zhen-Hong Zou Li-Ying Zhao Ting-Yu Mou Yan-Feng Hu Jiang Yu Hao Liu Hao Chen Jia-Ming Wu Sheng-Li An Guo-Xin Li | 2014 | World Journal of Gastroenterology2014，20，44： | 25 |
| 4 | Systematic review and meta-analysis of laparoscopy-assisted and open total gastrectomy for gastric cancer显示文摘AIM:To evaluate the safety and efficacy of laparoscopy-assisted total gastrectomy(LATG)and open total gastrectomy(OTG)for gastric cancer.METHODS:A comprehensive search of PubMed,Cochrane Library,Web of Science and BIOSIS Previews was performed to identify studies that compared LATG and OTG.The following factors were checked:operating time,blood loss,harvested lymph nodes,flatus time,hospital stay,mortality and morbidity.Data synthesis and statistical analysis were carried out using RevMan 5.1 software.RESULTS:Nine studies with 1221 participants were included(436 LATG and 785 OTG).Compared to OTG,LATG involved a longer operating time[weighted mean difference(WMD)=57.68 min,95%CI:30.48-84.88;P<0.001];less blood loss[standard mean difference(SMD)=-1.71;95%CI:-2.48--0.49;P<0.001];earlier time to flatus(WMD=-0.76 d;95%CI:-1.22--0.30;P<0.001);shorter hospital stay(WMD=-2.67d;95%CI:-3.96--1.38,P<0.001);and a decrease in medical complications(RR=0.41,95%CI:0.19-0.90,P=0.03).The number of harvested lymph nodes,mortality,surgical complications,cancer recurrence rate and long-term survival rate of patients undergoing LATG were similar to those in patients undergoing OTG.CONCLUSION:Despite a longer operation,LATG can be performed safely in experienced surgical centers with a shorter hospital stay and fewer complications than open surgery. | Ke Chen Xiao-Wu Xu Ren-Chao Zhang Yu Pan Di Wu Yi-Ping Mou | 2013 | World Journal of Gastroenterology2013，19，32： | 23 |
| 5 | Laparoscopic distal pancreatectomy is as safe and feasible as open procedure:A meta-analysis显示文摘AIM:To evaluate the feasibility and safety of laparoscopic distal pancreatectomy(LDP) compared with open distal pancreatectomy(ODP).METHODS:Meta-analysis was performed using the databases,including PubMed,the Cochrane Central Register of Controlled Trials,Web of Science and BIOSIS Previews.Articles should contain quantitative data of the comparison of LDP and ODP.Each article was reviewed by two authors.Indices of operative time,spleen-preserving rate,time to fluid intake,ratio of malignant tumors,postoperative hospital stay,incidence rate of pancreatic fistula and overall morbidity rate were analyzed.RESULTS:Nine articles with 1341 patients who underwent pancreatectomy met the inclusion criteria.LDP was performed in 501(37.4%) patients,while ODP was performed in 840(62.6%) patients.There were significant differences in the operative time,time to fluid intake,postoperative hospital stay and spleen-preserving rate between LDP and ODP.There was no difference between the two groups in pancreatic fistula rate [random effects model,risk ratio(RR) 0.996(0.663,1.494),P = 0.983,I2 = 28.4%] and overall morbidity rate [random effects model,RR 0.81(0.596,1.101),P = 0.178,I2 = 55.6%].CONCLUSION:LDP has the advantages of shorter hospital stay and operative time,more rapid recovery and higher spleen-preserving rate as compared with ODP. | Kun Xie Yi-Ping Zhu Xiao-Wu Xu Ke Chen Jia-Fei Yan Yi-Ping Mou | 2012 | World Journal of Gastroenterology2012，18，16： | 22 |
| 6 | Anti-disturbance control of hypersonic flight vehicles with input saturation using disturbance observer显示文摘This paper proposes an anti-disturbance control scheme for the near space vehicle(NSV) based on terminal sliding mode(TSM) technique and disturbance observer method. To tackle the system uncertainty and the time-varying unknown external disturbance of the NSV, a disturbance observer based on TSM technique is designed which can render the disturbance estimate error convergent in finite time. Furthermore, an auxiliary design system is introduced to analyze the input saturation effect. Based on the developed disturbance observer and the auxiliary design system, an anti-disturbance attitude control scheme is developed for the NSV using the TSM technique to speed up the convergence of all signals in closed-loop system. For the closed-loop system,the stability is rigorously proved by using the Lyapunov method and we guarantee the finite time convergence of all closed-loop system signals in the presence of the integrated affection of the system uncertainty, the input saturation, and the unknown external disturbance. Simulation study results are given to show the effectiveness of the developed TSM anti-disturbance attitude control scheme using the disturbance observer and the auxiliary system for the NSV. | CHEN Mou REN BeiBei WU QinXian JIANG ChangSheng | 2015 | Science China(Information Sciences)2015，58，7： | 21 |
| 7 | Totally laparoscopic gastrectomy for gastric cancer: A systematic review and meta-analysis of outcomes compared with open surgery显示文摘AIM:To systematically review the surgical outcomes of totally laparoscopic gastrectomy(TLG)vs open gastrectomy(OG)for gastric cancer.METHODS:A systematic search of PubMed,Embase,Cochrane Library,and Web of Science was conducted.All original studies comparing TLG with OG were included for critical appraisal.Data synthesis and statistical analysis were carried out using RevMan 5.1 software.RESULTS:One RCT and 13 observational studies involving 1532 patients were included(721 TLG and811 OG).TLG was associated with longer operation time[weighted mean difference(WMD)=58.04min,95%CI:37.77-78.32,P<0.001],less blood loss[WMD=-167.57 min,95%CI:-208.79-(-126.34),P<0.001],shorter hospital stay[WMD=-3.75 d,95%CI:-4.88-(-2.63),P<0.001]and fewer postoperative complications(RR=0.71,95%CI:0.58-0.86,P<0.001).The number of harvested lymph nodes,surgical margin,mortality and cancer recurrence rate were similar between the two groups.CONCLUSION:TLG may be a technically safe,feasible and favorable approach in terms of better cosmesis,less blood loss and faster recovery compared with OG. | Ke Chen Yu Pan Jia-Qin Cai Xiao-Wu Xu Di Wu Yi-Ping Mou | 2014 | World Journal of Gastroenterology2014，20，42： | 19 |
| 8 | Guaranteed transient performance based control with input saturation for near space vehicles显示文摘This paper describes the design of guaranteed transient performance based attitude control for the near space vehicle(NSV)with control input saturation using the backstepping method.To improve the robust controllability of the NSV,the parameter adaptive method is used to tackle the integrated effect of unknown time-varying disturbance and control input saturation.Based on the backstepping technique and parameter estimated outputs,a robust attitude control scheme is proposed for the NSV with input saturation.A novel robust attitude control scheme is then proposed based on a prescribed performance bound(PPB)which characterizes the convergence rate and maximum overshoot of the attitude tracking error.The closed-loop system stability under both the developed robust attitude control schemes is proved using Lyapunov’s method and uniformly asymptotical convergence of all closed-loop signals is guaranteed.Finally,simulation results are given to show the effectiveness of both the proposed robust constrained attitude control schemes. | CHEN Mou WU QinXian JIANG ChangSheng JIANG Bin | 2014 | Science China(Information Sciences)2014，57，5： | 19 |
| 9 | Reassessment of subacute MPTP-treated mice as animal model of Parkinson's disease显示文摘1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP ) 老鼠模型仍然是 Parkinsons 疾病(PD ) 的最通常使用的动物模型。有三个 MPTP 处理计划:尖锐、稍尖、长期。就到 PD 的经期和类似的优点而言,稍尖的模型经常被选择估计新候选人的有效性,但是变化为进一步要证实的这个模型遗体由稍尖的 MPTP 治疗和适当积极控制引起。这研究的目的是:为了估计稍尖的 MPTP 鼠标的值,并且发现有效的积极的药,在行为的性能,生物化学的变化和病理学的畸形的方面当模特儿。男 C57BL/6 老鼠与 MPTP 被注射(这研究的 30 mgThe 结果证明 RVR 与中高音(P=0.015 ) 被联系,著名计算机生产厂商(P=0.020 ) , IFNL3 rs12979860 (CC )(P=0.043 ) , rs12980275 (AA )(P=1 n 减少了饮食的 CF.Subjects/Methods:在饮食的 CF 的变化在参予重量损失试用的 61 个喂奶的女人之中被分析。食物吸入数据从 4 天称?? | Qiu-shuang ZHANG Yang HENG Zheng MOU Ju-yang HUANG Yu-he YUAN Nai-hong CHEN | 2017 | Acta Pharmacologica Sinica2017，38，10： | 18 |
| 10 | Adaptive fuzzy tracking control for a class of uncertain MIMO nonlinear systems using disturbance observer显示文摘In this paper,the adaptive fuzzy tracking control is proposed for a class of multi-input and multioutput(MIMO)nonlinear systems in the presence of system uncertainties,unknown non-symmetric input saturation and external disturbances.Fuzzy logic systems(FLS)are used to approximate the system uncertainty of MIMO nonlinear systems.Then,the compound disturbance containing the approximation error and the timevarying external disturbance that cannot be directly measured are estimated via a disturbance observer.By appropriately choosing the gain matrix,the disturbance observer can approximate the compound disturbance well and the estimate error converges to a compact set.This control strategy is further extended to develop adaptive fuzzy tracking control for MIMO nonlinear systems by coping with practical issues in engineering applications,in particular unknown non-symmetric input saturation and control singularity.Within this setting,the disturbance observer technique is combined with the FLS approximation technique to compensate for the efects of unknown input saturation and control singularity.Lyapunov approach based analysis shows that semi-global uniform boundedness of the closed-loop signals is guaranteed under the proposed tracking control techniques.Numerical simulation results are presented to illustrate the efectiveness of the proposed tracking control schemes. | CHEN Mou CHEN WenHua WU QinXian | 2014 | Science China(Information Sciences)2014，57，1： | 17 |
| 11 | Staging laparoscopy improves treatment decision-makingfor advanced gastric cancer显示文摘AIM To evaluate the clinical value of staging laparoscopyin treatment decision-making for advancedgastric cancer (GC).METHODS: Clinical data of 582 patients with advancedGC were retrospectively analyzed. All patientsunderwent staging laparoscopy. The strength ofagreement between computed tomography (CT) stage,endoscopic ultrasound (EUS) stage, laparoscopic stage,and final stage were determined by weighted Kappastatistic (Kw). The number of patients with treatmentdecision-changes was counted. A χ 2 test was used toanalyze the correlation between peritoneal metastasisor positive cytology and clinical characteristics.RESULTS: Among the 582 patients, the distributions ofpathological T classifications were T2/3 (153, 26.3%),T4a (262, 45.0%), and T4b (167, 28.7%). Treatmentplans for 211 (36.3%) patients were changed after staging laparoscopy was performed. Two (10.5%) of19 patients in M1 regained the opportunity for potentialradical resection by staging laparoscopy. Unnecessarylaparotomy was avoided in 71 (12.2%) patients. Thestrength of agreement between preoperative T stageand final T stage was in almost perfect agreement (Kw= 0.838; 95% confidence interval (CI): 0.803-0.872;P 〈 0.05) for staging laparoscopy; compared with CTand EUS, which was in fair agreement. The strengthof agreement between preoperative M stage andfinal M stage was in almost perfect agreement (Kw= 0.990; 95% CI: 0.977-1.000; P 〈 0.05) for staginglaparoscopy; compared with CT, which was in slightagreement. Multivariate analysis revealed that tumorsize (≥ 40 mm), depth of tumor invasion (T4b), andBorrmann type (Ⅲ or Ⅳ) were significantly correlatedwith either peritoneal metastasis or positive cytology.The best performance in diagnosing P-positive wasobtained when two or three risk factors existed.CONCLUSION: Staging laparoscopy can improvetreatment decision-making for advanced GC anddecrease unnecessary exploratory laparotomy. | Yan-Feng Hu Zhen-Wei Deng Hao Liu Ting-Yu Mou Tao Chen Xin Lu Da Wang Jiang Yu Guo-Xin Li | 2016 | World Journal of Gastroenterology2016，22，5： | 17 |
| 12 | Case-matched comparison of laparoscopy-assisted and open distal gastrectomy for gastric cancer显示文摘AIM: To compare shortand long-term outcomes of laparoscopy-assisted and open distal gastrectomy for gastric cancer. METHODS: A retrospective study was performed by comparing the outcomes of 54 patients who underwent laparoscopy-assisted distal gastrectomy (LADG) with those of 54 patients who underwent open distal gastrectomy (ODG) between October 2004 and October 2007. The patients' demographic data (age and gender), date of surgery, extent of lymphadenectomy, and differentiation and tumor-node-metastasis stage of the tumor were examined. The operative time, intraoperative blood loss, postoperative recovery, complications, pathological findings, and follow-up data were compared between the two groups.RESULTS: The mean operative time was significantly longer in the LADG group than in the ODG group (259.3 ± 46.2 min vs 199.8 ± 40.85 min; P < 0.05), whereas intraoperative blood loss and postoperative complications were significantly lower (160.2 ± 85.9 mL vs 257.8 ± 151.0 mL; 13.0% vs 24.1%, respectively, P < 0.05). In addition, the time to first flatus, time to initiate oral intake, and postoperative hospital stay were significantly shorter in the LADG group than in the ODG group (3.9 ± 1.4 d vs 4.4 ± 1.5 d; 4.6 ± 1.2 d vs 5.6 ± 2.1 d; and 9.5 ± 2.7 d vs 11.1 ± 4.1 d, respectively; P < 0.05). There was no significant difference between the LADG group and ODG group with regard to the number of harvested lymph nodes. The median followup was 60 mo (range, 5-97 mo). The 1-, 3-, and 5-year disease-free survival rates were 94.3%, 90.2%, and 76.7%, respectively, in the LADG group and 89.5%, 84.7%, and 82.3%, respectively, in the ODG group. The 1-, 3-, and 5-year overall survival rates were 98.0%, 91.9%, and 81.1%, respectively, in the LADG group and 91.5%, 86.9%, and 82.1%, respectively, in the ODG group. There was no significant difference between the two groups with regard to the survival rate. CONCLUSION: LADG is suitable and minimally invasive for treating distal gastric cancer and can achieve similar long-term results to ODG. | Wei Wang Ke Chen Xiao-Wu Xu Yu Pan Yi-Ping Mou | 2013 | World Journal of Gastroenterology2013，19，23： | 15 |
| 13 | Laparoscopic vs open distal pancreatectomy for solid pseudopapillary tumor of the pancreas显示文摘AIM:To compare short-and long-term outcomes of laparoscopic vs open distal pancreatectomy for solid pseudopapillary tumor(SPT)of the pancreas.METHODS:This retrospective study included 28 patients who underwent distal pancreatectomy for SPT of the pancreas between 1998 and 2012.The patients were divided into two groups based on the surgical approach:the laparoscopic surgery group and the open surgery group.The patients’demographic data,operative results,pathological reports,hospital courses,morbidity and mortality,and follow-up data were compared between the two groups.RESULTS:Fifteen patients with SPT of the pancreas underwent laparoscopic distal pancreatectomy(LDP),and 13 underwent open distal pancreatectomy(ODP).Baseline characteristics were similar between the two groups except for a female predominance in the LDP group(100.0%vs 69.2%,P=0.035).Mortality,morbidity(33.3%vs 38.5%,P=1.000),pancreatic fistula rates(26.7%vs 30.8%,P=0.728),and reoperation rates(0.0%vs 7.7%,P=0.464)were similar in the two groups.There were no significant differences in the operating time(171 min vs 178 min,P=0.755)between the two groups.The intraoperative blood loss(149 mL vs 580 mL,P=0.002),transfusion requirement(6.7%vs 46.2%,P=0.029),first flatus time(1.9d vs 3.5 d,P=0.000),diet start time(2.3 d vs 4.9 d,P=0.000),and postoperative hospital stay(8.1 d vs 12.8d,P=0.029)were significantly less in the LDP group than in the ODP group.All patients had negative surgical margins at final pathology.There were no significant differences in number of lymph nodes harvested(4.6 vs6.4,P=0.549)between the two groups.The median follow-up was 33(3-100)mo for the LDP group and 45(17-127)mo for the ODP group.All patients were alive with one recurrence.CONCLUSION:LDP for SPT has short-term benefits compared with ODP.Long-term outcomes of LDP are similar to those of ODP. | Ren-Chao Zhang Jia-Fei Yan Xiao-Wu Xu Ke Chen Harsha Ajoodhea Yi-Ping Mou | 2013 | World Journal of Gastroenterology2013，19，37： | 14 |
| 14 | Intracorporeal esophagojejunostomy after totally laparoscopic total gastrectomy: A single-center 7-year experience显示文摘AIM: To assess the efficacy and safety of intracorporeal esophagojejunostomy in patients undergoing laparoscopic total gastrectomy(LTG) for gastric cancer.METHODS: A retrospective review of 81 consecutive patients who underwent LTG with the same surgical team between November 2007 and July 2014 was performed. Four types of intracorporeal esophagojejunostomy using staplers or hand-sewn suturing were performed after LTG. Data on clinicopatholgoical characteristics, occurrence of complications, postoperative recovery, anastomotic time, and operation time among the surgical groups were obtained through medical records.RESULTS: The average operation time was 288.7 min, the average anastomotic time was 54.3 min, and the average estimated blood loss was 82.7 m L. There were no cases of conversion to open surgery. The first flatus was observed around 3.7 d, while the liquid diet was started, on average, from 4.9 d. The average postoperative hospital stay was 10.1 d. Postoperative complications occurred in 14 patients, nearly 17.3%.However, there were no cases of postoperative death.CONCLUSION: LTG performed with intracorporeal esophagojejunostomy using laparoscopic staplers or hand-sewn suturing is feasible and safe. The surgical results were acceptable from the perspective of minimal invasiveness. | Ke Chen Yu Pan Jia-Qin Cai Xiao-Wu Xu Di Wu Jia-Fei Yan Rong-Gao Chen Yang He Yi-Ping Mou | 2016 | World Journal of Gastroenterology2016，22，12： | 14 |
| 15 | Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma显示文摘AIM:To investigate the association of Rab27A and Rab27B expression with clinicopathological characteristics and prognosis of hepatocellular carcinoma(HCC).METHODS:We used reverse transcription polymerase chain reaction(RT-PCR),real-time PCR,and Western blotting to detect Rab27A and Rab27B mRNA and protein expression in 5 human HCC lines and the immortalized hepatic HL-7702 cell line.We further examined 148 primary HCC samples matched with adjacent normal tissue and 80 non-HCC specimens by immunohistochemistry to evaluate the correlation of Rab27A and Rab27B expression with clinicopathological features and prognosis.RESULTS:Our data showed that Rab27A and Rab27Bwere differentially expressed in cell lines and primary HCC tumors.Rab27A mRNA and protein were detected in 67%(4/6)of human cell lines and 80%(4/5)of HCC cell lines,while Rab27B was found in 50%(3/6)of human lines and 40%(2/5)of HCC lines.Rab27A expression was higher in primary HCC(46.2%,66/143)than in matched adjacent tissue(24.3%,33/136,P<0.001),whereas immunopositivity for Rab27B was lower in primary HCC(57.4%,81/141)than in matched adjacent tissue(87.5%,119/136,P<0.001).Analysis of clinicopathological characteristics of 148 HCC specimens revealed significant correlations between Rab27A and Rab27B expression and tumor tumor-node-metastasis(TNM)classification(P=0.046 and P=0.027,respectively),and between strong Rab27A expression and tumor differentiation grade(P=0.008).Survival analyses revealed that patients with Rab27A+or Rab27B+tumors had significantly reduced overall survival compared with that of patients with Rab27A-or Rab27B-tumors(P= 0.015 and P=0.005,respectively).Risk analyses revealed that Rab27B+and TNMⅢ-Ⅳwere independent poor prognosis factors associated with a 3.36-and 3.37fold higher relative risk of death,respectively.CONCLUSION:Rab27A and Rab27B expression were closely correlated with tumor progression and can be valuable prognostic indicators for HCC patients. | Wei-Wei Dong Quan Mou Jian Chen Jian-Tao Cui Wen-Mei Li Wen-Hua Xiao | 2012 | World Journal of Gastroenterology2012，18，15： | 13 |
| 16 | Progress in application of CFD techniques显示文摘Computational Fluid Dynamics (CFD) is an important branch of fluid mechanics, and will continue to play great roles on the design of aerospace vehicles, explora- tion of new concept vehicles and new aerodynamic technology. This paper will present the progress of CFD from point of view of engineering application in recent years at CARDC, including the software integration, grid technique, speeding up of convergence, unsteady fluid computation,etc., and also give some engineering application examples of CFD at CARDC. | CHEN ZuoBin JIANG Xiong ZHOU Zhu XIAO HanShan HUANG Yong MOU Bin XIAO ZhongYun LIU Gang WANG YunTao | 2008 | Science China(Technological Sciences)2008，51，7： | 13 |
| 17 | Resection of a cholangiocarcinoma via laparoscopic hepatopancreato- duodenectomy:A case report显示文摘Some laterally advanced cholangiocarcinomas behave as ductal spread or local invasion,and hepatopancreatoduodenectomy(HPD)may be performed for R0 resection.To date,there have been no reports of laparoscopic HPD(LHPD)in the English literature.We report the first case of LHPD for the resection of a BismuthⅢa cholangiocarcinoma invading the duodenum.The patient underwent laparoscopic pancreaticoduodenectomy and right hemihepatectomy.Child’s approach was used for the reconstruction.The patient recovered well with bile leakage from the 2nd postoperative day and was discharged on the 16th postoperative day with a drainage tube in place which was removed 2 wk after discharge.Postoperative pathology revealed a well-differentiated cholangiocarcinoma andthe margin of liver parenchyma,pancreas and stomach was negative for metastases.The results suggest that LHPD is a feasible and safe procedure when performed in highly specialized centers and in suitable patients with cholangiocarcinoma. | Miao-Zun Zhang Xiao-Wu Xu Yi-Ping Mou Jia-Fei Yan Yi-Ping Zhu Ren-Chao Zhang Yu-Cheng Zhou Ke Chen Wei-Wei Jin Erik Matro Harsha Ajoodhea | 2014 | World Journal of Gastroenterology2014，20，45： | 12 |
| 18 | Codon 249 mutations of p53 gene in non-neoplastic liver tissues显示文摘Subjectheadingsliver;p53gene;codon249mutation;liverneoplasms;hepatitis,viral;livercirhosis;polymerasechainreactionAbstractAIM... | PENG Xiao Mou, YAO Chun Lan, CHEN Xue Juan, PENG Wen Wei and GAO Zhi Liang | 1999 | World Journal of Gastroenterology1999，5，4： | 12 |
| 19 | Adaptive dynamic surface control of NSVs with input saturation using a disturbance observer显示文摘An adaptive dynamic surface control(DSC)scheme is proposed for the multi-input and multi-output(MIMO)attitude motion of near-space vehicles(NSVs)in the presence of external disturbance,system uncertainty and input saturation.The external disturbance and the system uncertainty are efficiently tackled using a Nussbaum disturbance observer(NDO),and the adaptive controller is constructed by combining the dynamic surface control technique to handle the problem of‘‘explosion of complexity’’inherent in the conventional backstepping method.For handling the input saturation,an auxiliary system is designed with the same order as that of the studied MIMO attitude system.Using the error between the saturation input and the desired control input as the input of the designed auxiliary system,a series of signals are generated to compensate for the effect of the saturation in the dynamic surface control design.It is proved that the developed control scheme can guarantee that all signals of the closed-loop control system are semi-globally uniformly bounded.Finally,simulation results illustrate that the proposed control scheme can achieve satisfactory tracking performance under the composite effects of the input saturation and the external disturbance. | Chen Mou Yu Jing | 2015 | Chinese Journal of Aeronautics2015，28，3： | 12 |
| 20 | Laparoscopic spleen-preserving distal pancreatectomy for pancreatic neoplasms:A retrospective study显示文摘AIM:To describe the clinical characteristics,technical procedures,and outcomes of patients undergoing laparoscopic spleen-preserving distal pancreatectomy(LSPDP)for benign and malignant pancreatic neoplasms.METHODS:The clinical data of 38 patients who underwent LSPDP in the Sir Run Run Shaw Hospital between January 2003 and August 2013 were analyzed retrospectively.Surgical techniques for LSPDP included preservation of the splenic artery and vein(Kimura’s technique)and ligation of the splenic pedicle with preservation of the short gastric vessels(Warshaw’s technique).RESULTS:There were no conversions to open surgery in the 38 patients.Splenic vessels were conserved during spleen-preserving pancreatectomy,except in two patients who underwent resection of the splenic vessels and preservation only of the short gastric vessels.The mean operation time was 123.2±52.4 min,the mean intraoperative blood loss was 78.2±39.5 mL,and the mean postoperative hospital stay was 7.6±2.9 d.The overall rate of postoperative complications was 18.4%(7/38),and the rate of clinical pancreatic fistula was13.2%(5/38).All postoperative complications were treated conservatively.The postoperative pathological diagnoses were 22 cases of benign pancreatic disease and 16 cases of borderline or low-grade malignant lesions.During a median follow-up of 38 mo(range:5-133mo),no recurrence was observed.CONCLUSION:LSPDP is a safe,feasible and effective procedure for the treatment of benign and low-grade malignant tumors of the distal pancreas. | Jia-Fei Yan Xiao-Wu Xu Wei-Wei Jin Chao-Jie Huang Ke Chen Ren-Chao Zhang Ajoodhea Harsha Yi-Ping Mou | 2014 | World Journal of Gastroenterology2014，20，38： | 11 |
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