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| 1 | Unusual life-threatening Rosai-Dorfman disease of the trachea. role of NF-kappa B显示文摘 | Zhou, LF Chen, LA Zhu, QA Wang, C Xu, H Cui, XF Jiang, LF He, Ski Huang, M Yin, KS | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 21 |
| 2 | Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53显示文摘Our preliminary study shows that cinnamaldehyde(CA)could protect against intestinal ischemia/reperfusion(I/R)injuries,in which p53 and NF-κB p65 play a synergistic role.In this study,we conducted in vivo and in vitro experiments to verify this proposal.SD rats were pretreated with CA(10 or 40 mg·kg−1·d−1,ig)for 3 days,then subjected to 1 h mesenteric ischemia followed by 2 h reperfusion.CA pretreatment dose-dependently ameliorated morphological damage and reduced inflammation evidenced by decreased TNF-α,IL-1β,and IL-6 levels and MPO activity in I/R-treated intestinal tissues.CA pretreatment also attenuated oxidative stress through restoring SOD,GSH,LDH,and MDA levels in I/R-treated intestinal tissues.Furthermore,CA pretreatment significantly reduced the expression of inflammation/apoptosis-related NF-κB p65,IKKβ,IK-α,and NF-κB p50,and downregulated apoptotic protein expression including p53,Bax,caspase-9 and caspase-3,and restoring Bcl-2,in I/R-treated intestinal tissues.We pretreated IEC-6 cells in vitro with CA for 24 h,followed by 4 h hypoxia and 3 h reoxygenation(H/R)incubation.Pretreatment with CA(3.125,6.25,and 12.5μmol·L−1)significantly reversed H/R-induced reduction of IEC-6 cell viability.CA pretreatment significantly suppressed oxidative stress,NF-κB activation and apoptosis in H/R-treated IEC-6 cells.Moreover,CA pretreatment significantly reversed mitochondrial dysfunction in H/R-treated IEC-6 cells.CA pretreatment inhibited the nuclear translocation of p53 and NF-κB p65 in H/R-treated IEC-6 cells.Double knockdown or overexpression of p53 and NF-κB p65 caused a synergistic reduction or elevation of p53 compared with knockdown or overexpression of p53 or NF-κB p65 alone.In H/R-treated IEC-6 cells with double knockdown or overexpression of NF-κB p65 and p53,CA pretreatment caused neither further decrease nor increase of NF-κB p65 or p53 expression,suggesting that CA-induced synergistic inhibition on both NF-κB and p53 played a key role in ameliorating intestinal I/R injuries.Finally,we used immunoprecipitation assay to demonstrate an interaction between p53 and NF-κB p65,showing the basis for CA-induced synergistic inhibition.Our results provide valuable information for further studies. | Marwan Almoiliqy Jin Wen Bin Xu Yu-chao Sun Meng-qiao Lian Yan-li Li Eskandar Qaed Mahmoud Al-Azab Da-peng Chen Abdullah Shopit Li Wang Peng-yuan Sun Yuan Lin | 2020 | Acta Pharmacologica Sinica2020，41，9： | 5 |
| 3 | Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors显示文摘 | Huang CHj Yuan Qa Chen PJ | 2012 | J Hepatol2012，57，4： | 1 |
| 4 | Anti-AIDS agents, 4 tripterfordin, a novel anti-HIV principle from Tripterygium wilfordii : Isolation and structural elucidation 显示文摘 | Chen K Shi QA Fujioka T | 1992 | J Nat Prod1992，55，1： | 1 |
| 5 | Anti-AIDS agents, 4 tripter fordin,a novel anti-HIV principle from tripterygium wilfordii:isolation and structural elucidation 显示文摘 | Chen K Shi QA Fujioka T | 1992 | J Nat Prod1992，55，1： | 1 |
| 6 | A targeted fimA DNA vaccine prevents alveolar bone loss in mice after intra-nasal administration显示文摘 | Yu F Xu QA Chen W | 2011 | J Clin Periodontol2011，38，4： | 1 |
| 7 | Effect of the GLP-1 analog exendin- 4 and oxaliplatin on intrahepatic cholangiocarcinoma cell line and mouse model 显示文摘 | Chen BD Zhao WC Jia QA | 2013 | Int J Mol Sci2013，14，24： | 1 |
| 8 | Common Expression of Stem- ness Molecular Markers and Early Cardiac Transcription Factors In Wharton's Jelly- Derived Mesenchymal Stem Ceils and hESCs 显示文摘 | Gao LR Chen HY Ding QA | 2013 | Cell Transplant2013，22，10： | 1 |
| 9 | Model-Based Energy anagement Strategy Development for Hybrid Electric Vehicles显示文摘 | Guo QA Qiang JX Chen ZQ | 2008 | Industrial Electronics2008，，7： | 1 |
| 10 | Dynamic changes of the cervical ligamental flavum in hyperextension-hyperflexion movement and their measurements显示文摘 | Jia LS Shen QA Chen DY | 1990 | Chin Med J (Engl)1990，103，1： | 1 |
| 11 | A Novel Magnetic Nanopartie]e Hyperthermia Combined with ACMF Dependant Drug Release by DAMMs injection in VX-2 Liver Tumors显示文摘 | Zhang QA Tong JL Chen HJ | 2012 | Journal of nanoscience and nanotechnology2012，12，12： | 1 |
| 12 | Chrysie and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells 显示文摘 | ZHANG T CHEN X L QA L B | 2004 | Bioorg Med Chem2004，12，23： | 1 |
| 13 | Prevalence of diabetes among men and women in China 显示文摘 | Yang WY Lu JM Weng JP Jia WP Ji LN Xiao JZ Shah ZY Liu J Tian HM Ji QH Zhu DL Ge JP Lin LX Chen H Guo XG Zhao ZG Li QA Zhou ZG Shan GL He J 2010 | 2010 | NEnglJMed2010，362，25： | 1 |
| 14 | Furazolidone induced oxidative DNA damage via up - regulating ROS that caused cell cycle arrest in human hepatoma G2 cells 显示文摘 | Jin X Tang SS Chen QA | 2011 | Toxicology letters2011，201，3： | 1 |
| 15 | Minimally invasive surgery for spontaneous supratentorial intracerebral hemorrhage: a meta- analysis of randomized controlled trials显示文摘 | Zhou X Chen J Li Qa | 2012 | Stroke2012，43，11： | 1 |
| 16 | A novel magnetic nanoparticle hyperthermia combined with ACMF Dependant drug release by DAMMs injection in VX-2 liver tumors显示文摘 | Zhang QA Tong JL Chen HJ | 2012 | J Nanosci Nanotechnol2012，12，： | 1 |
| 17 | GDF-8 propeptide binds to GDF-8 and antagonizes biological activity by inhibiting GDF-8 receptor binding显示文摘 | Thies RS Chen T Davies MV Tomkinson KN Pearson AA Shakey QA Wolfman NM | 2001 | Growth Factors2001，18，： | 1 |
| 18 | Role of plasminogen activator and plasminogen activator inhibitor type-1 in luteolysis——a minireview显示文摘This minireview summarized our recent studies on the role of plasminogen activator (PA) and inhibitor type-1 (PAI-1) in luteolysis. We have demonstrated that (1) both tissue type and urokinase type plasminogen activators (tPA and uPA) and a plasminogen activator inhibitor type-1 (PAI-1) were present in the corpus luteum of rat and rhesus monkey; (2) decrease in progesterone production in corpus luteum was well correlated with a sharp increase in tPA (but not uPA) and PAI-1 secretion; (3) exogenous tPA decreased luteal progesterone synthesis while monoclonal antibodies increased progesterone production; (4) interferon y inhibited luteal progesterone synthesis and stimulated tPA production while LH plus pro-lactin increased progesterone production and decreased tPA (but not uPA) activity in cultured luteal cells; (5) increase in proteolysis in the corpus luteum was also correlated with decrease in progesterone production in mouse. These data suggest that local degradation of extracellular matrix | Liu, YX Chen, YJ Feng, QA Hu, ZY | 1997 | Chinese Science Bulletin1997，42，23： | 0 |
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