| 1 | Influencing factors of pancreatic microcirculatory impairment in acute panceatitis显示文摘Pancreatic microcirculatory disturbance plays an importantrole in the pathogenesis of acute pancreatitis, and itinvolves a series of changes including vasoconstriction,ischaemia, increased vascular permeability, impairment ofnutritive tissue perfusion, ischaemia/reperfusion, leukocyteadherence, hemorrheological changes and impairedlymphatic drainage. Ischaemia possibly acts as an initiatingfactor of pancreatic microcirculatory injury in acutepancreatitis, or as an aggravating/continuing mechanism.The end-artery feature of the intralobular arterioles suggeststhat the pancreatic microcirculation is highly susceptible toischaemia. Various vasoactive mediators, as bradykinin,platelet activating factor, endothelin and nitric oxideparticipate in the development of microcirculatory failure. | Zhou2G ChenYD 等 | 2002 | World Journal of Gastroenterology2002，8，3： | 53 |
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