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15篇 您的检索式：作者名="Cheng Ching Yu"

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		题名	作者	年代	出处	被引量
	1	A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction显示文摘Hyperhomocysteinemia(HHcy)is an independent risk factor for cardiovascular diseases and increases mortality in type 2 diabetic patients.HHcy induces endoplasmic reticulum(ER)stress and oxidative stress to impair endothelial function.The glucagon-like peptide 1(GLP-1)analog exendin-4 attenuates endothelial ER stress,but the detailed vasoprotective mechanism remains elusive.The present study investigated the beneficial effects of exendin-4 against HHcy-induced endothelial dysfunction.Exendin-4 pretreatment reversed homocysteine-induced impairment of endothelium-dependent relaxations in C57BL/6 mouse aortae ex vivo.Four weeks subcutaneous injection of exendin-4 restored the impaired endothelial function in both aortae and mesenteric arteries isolated from mice with diet-induced HHcy.Exendin-4 treatment lowered superoxide anion accumulation in the mouse aortae both ex vivo and in vivo.Exendin-4 decreased the expression of ER stress markers(e.g.,ATF4,spliced XBP1,and phosphorylated eIF2α)in human umbilical vein endothelial cells(HUVECs),and this change was reversed by cotreatment with compound C(CC)(AMPK inhibitor).Exendin-4 induced phosphorylation of AMPK and endothelial nitric oxide synthase in HUVECs and arteries.Exendin-4 increased the expression of endoplasmic reticulum oxidoreductase(ERO1α),an important ER chaperone in endothelial cells,and this effect was mediated by AMPK activation.Experiments using siRNA-mediated knockdown or adenoviral overexpression revealed that ERO1αmediated the inhibitory effects of exendin-4 on ER stress and superoxide anion production,thus ameliorating HHcy-induced endothelial dysfunction.The present results demonstrate that exendin-4 reduces HHcy-induced ER stress and improves endothelial function through AMPK-dependent ERO1αupregulation in endothelial cells and arteries.AMPK activation promotes the protein folding machinery in endothelial cells to suppress ER stress.	Chak Kwong Cheng Jiang-Yun Luo Chi Wai Lau William Chi-shing Cho Chi Fai Ng Ronald Ching Wan Ma Xiao Yu Tian Yu Huang	2021	Acta Pharmacologica Sinica2021，42，10：	6
	2	Shikonin derivatives inhibited LPS-induced NOS in RAW 264.7 cells via downregulation of MAPK/NF-κB signaling显示文摘	Yu Wen Cheng Ching Yi Chang Kou Lung Lin Chien Ming Hu Cheng Hui Lin Jaw Jou Kang	2008	Journal of Ethnopharmacology2008，，2：	1
	3	Expression of hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF)-D as outcome predictors in resected esophageal squamous cell carcinoma显示文摘	Ching Tzao Shih-Chun Lee Ho-Jui Tung Han-Shui Hsu Wen-Hu Hsu Guang-Huan Sun Cheng-Ping Yu Jong-Shiaw Jin Yeung-Leung Cheng	2008	Disease Markers2008，，3：	1
	4	Intratypic variants of human papillomavirus type 16 and risk of cervical Neoplasia in Taiwan显示文摘	Ya‐Ju Chang Hui‐Chi Chen Mei‐Hung Pan Bor‐Heng Lee San‐Lin You Ching‐Yu Lin Yi‐Chun Chou Chang‐Yao Hsieh Yu‐Juen Cheng Kai‐Li Liaw Ann W. Hsing Mark Schiffman Chien‐Jen Chen	2013	J. Med. Virol2013，，：	1
	5	A study of implementing Balanced Scorecard (BSC) in non -profit organizations : A case study of private hospital显示文摘	CHING - CHOW YANG LAI - YU ChENG AND CHIH - WEI YANG	2005	Human Systems Management2005，，24：	1
	6	Effects of relative volatility ranking to the design of reactive distillation显示文摘	TUNG Shih Tse YU Cheng Ching	2007	AICh E Journal2007，53，5：	1
	7	Fault diagnosis based on qualitative/quantitative process knowledge显示文摘	YU CHENG CHING LEE CHYUAN	1991	AIChE J1991，37，4：	1
	8	qenetics of Is- chemic Stroke in Young Adults显示文摘	Yu Ching Cheng John W Cole Steven J kittner	2014	Oirc Cardiovasc Genet2014，7，3：	1
	9	A study of implementing Balanced Scorecard (BSC) in non-profit case Study of private hospital显示文摘	Ching Chow Yang Cheng Lai Yu	2005	Human Systems Management2005，24，4：	1
	10	Genotoxicity of Motorcycle Exhaust Particles In Vivo and In Vitro显示文摘	Yu Wen Cheng Wen Wha Lee Ching Hao Li	2004	Toxicological sciences2004，81，：	1
	11	A preliminary study of RPC for repair and retrofitting materials显示文摘	Lee Ming Gin Kan Yu Cheng Chen Kuei Ching	2006	Journal of the Chinese Institute of Engineers2006，29，6：	1
	12	A multi - objective model for passenger train services planning: application to Taiwan' s high - speed rail line 显示文摘	CHANG HANG Yu - Hem Yeh Chung - Hsing SHEN Ching - Cheng	2000	Transportation Research Part B2000，34，2：	1
	13	Application of Soft Landing to The Process Control of Chemical Mechanical Polishing 显示文摘	Chiu Jian - bin Yu Cheng - ching Shen Shih - haur	2003	Microelectronic Engineering2003，65，3：	1
	14	Mutation analysis and characterization of alternative splice variants of the Wilson disease gene ATP7B显示文摘	Lei Wan Chang‐Hai Tsai Chin‐Moo Hsu Chin‐Chang Huang Chih‐Chao Yang Chiu‐Chu Liao Chin‐Ching Wu Yu‐An Hsu Cheng‐Chun Lee Su‐Ching Liu Wei‐De Lin Fuu‐Jen Tsai	2010	Hepatology2010，，5：	1
	15	Design and control of reactive distillation for ethyl and isopropyl acetates production with azeotropic feeds 显示文摘	I-Kuan Lai Shih Bo Hung Wan Jen Hung Cheng Ching Yu	2007	Chemical Engineering Science2007，62，：	1

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