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| 1 | Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication显示文摘Hepatitis B virus(HBV)can cause chronic hepatitis B,which may lead to cirrhosis and liver cancer.Type I interferon(IFN)is an approved drug for the treatment of chronic hepatitis B.However,the fundamental mechanisms of antiviral action by type I IFN and the downstream signaling pathway are unclear.TRIM25 is an IFN-stimulated gene(ISG)that has an important role in RIG-I ubiquitination and activation.Whether TRIM25 is induced in liver cells by type I IFN to mediate anti-HBV function remains unclear.Here we report that interleukin-27(IL-27)has a critical role in IFN-induced TRIM25 upregulation.TRIM25 induction requires both STAT1 and STAT3.In TRIM25 knockout HepG2 cells,type I IFN production was consistently attenuated and HBV replication was increased,whereas overexpression of TRIM25 in HepG2 cells resulted in elevated IFN production and reduced HBV replication.More interestingly,we found that TRIM25 expression was downregulated in HBV patients and the addition of serum samples from HBV patients could inhibit TRIM25 expression in HepG2 cells,suggesting that HBV might have involved a mechanism to inhibit antiviral ISG expression and induce IFN resistance.Collectively,our results demonstrate that type I IFN-induced TRIM25 is an important factor in inhibiting HBV replication,and the IFN-IL-27-TRIM25 axis may represent a new target for treating HBV infection. | Guangyun Tan Qingfei Xiao Hongxiao Song Feng Ma Fengchao Xu Di Peng Na Li Xiaosong Wang Junqi Niu Pujun Gao F Xiao-Feng Qin Genhong Cheng | 2018 | Cellular & Molecular Immunology2018，15，3： | 13 |
| 2 | A Model for Liquid-Diffusion Catalytically Grown Fibrous Carbon Material显示文摘A mechanism for the catalytically growth of vapor grown fibrous carbon (VGFC) preparing from the floating catalyst method has been proposed, in which liquid diffusion-determined diffusionof carbon atoms through catalyst particles is described mathematically, and the physical andchemical properties of the catalyst particIes during the growth process are taken into account.From the model the growth rate and grown length of VGFC are calculated theoretically whichcoincides with the experimental datal and the necessity of reducing gas such as hydrogen inpreparing VGFC is explained as to reduce Fe3C, which acts as intermediate catalyst shown bythe model. Fe3C formed on the surface of γ-Fe will stop the growth of carbon fiber if they cannot be reduced at once. Additionally, the growth temperature and diameter of VGFC are alsodiscussed in the paper. | Zhang, WG Cheng, HM Su, G Fan, YY Li, F Shen, ZH Zhou, BL | 1999 | Journal of Materials Science & Technology1999，15，1： | 2 |
| 3 | Combinatorial modification of multiple lignin traits in trees through multigene cotransformation 显示文摘 | Li L Zhou Y Cheng X F | 2003 | Plant Biology2003，100，8： | 1 |
| 4 | Sex Appeal Advertising:Gender Differences In Chinese Consumers' Responses显示文摘 | Liu F Li J Cheng H | | 0，，01： | 1 |
| 5 | A thermo-responsive affinity membrane with nano-structured pores and grafted poly(N-isopropylacrylamide) surface layer for hydrophobic adsorption显示文摘 | Meng T Xie R Chen Y C Cheng C J Li P F Ju X J Chu L Y | 2010 | Journal of Membrane Science2010，349，12： | 1 |
| 6 | Incidence and risk fac- tors of oral mucositis in paediatric and adolescent pa- tients undergoing chemotherapy显示文摘 | Cheng K K F Lee V Li C H | 2011 | Oral Oncol2011，47，3： | 1 |
| 7 | Numerical model for local scour under offshore pipelines 显示文摘 | LI F CHENG L | 1999 | Journal of Hydraulic Engineering1999，125，4： | 1 |
| 8 | Fluorescence study on the interaction of human serum albumin with bromsulphalein显示文摘 | Cheng F Q Wang Y P Li Z P | 2006 | Spectrochimica Acta2006，65，： | 1 |
| 9 | Enhanced magnetoelectric effects in laminate composites of Terfenol-D/Pb(Zr,Ti)O3 under resonant drive显示文摘 | DONGS X CHENG J R LI J F | 2003 | Applied Physics Letters2003，83，23： | 1 |
| 10 | Fluorescence stud y on the interaction of human serum albumin with brom- sulphalein显示文摘 | Cheng F Q Wang Y P Li Z P | 2006 | Spectrochimica Acta Part A2006，65，： | 1 |
| 11 | New similarity measures of intuitionistic fuzzy sets and application to pattern recognitions显示文摘 | Li D F Cheng C T | 2002 | Pattern Recognition Letters2002，23，13： | 1 |
| 12 | New similarity measures of intuitionistic fuzzy sets and application to pattern recognition显示文摘 | Li D F Cheng C T | | 0，，13： | 1 |
| 13 | New similarity measures of intuitionistic fuzzy sets and application to pattern recognitions显示文摘 | Li D F Cheng C T | 2002 | PatternRecognitionLetters2002，23，13： | 1 |
| 14 | Battery performance and photocatalytic activity of mesoporous anatase TiO2 nanospheres/graphene composites by template-free self-assembly 显示文摘 | Li N Liu G Zhen C Li F Zhang L L Cheng H M | 2011 | Advanced Functional Materials2011，21，9： | 1 |
| 15 | Expression patterns of genes involved in sugar metabolism and accumulation during apple fruit development 显示文摘 | LI M FENG F CHENG L | 2012 | PLoS One2012，7，33： | 1 |
| 16 | Desorption behaviors of BDE-28 and BDE-47 from natural soils with different organic carbon contents 显示文摘 | Liu W X Cheng F F Li W B | 2012 | Environmental Pollution2012，163，： | 1 |
| 17 | Biohydrometallurgical iron oxidation and precipitation: Part I-- Effect of pH on process performance显示文摘 | KAKSONEN A H MORRIS C REA S LI J WYLIE J USHER K M G1NIGE M P CHENG K Y HILARIO F du PLESSIS C A | 2014 | Hydrometallurgy2014，，： | 1 |
| 18 | Polyamines in sow colostrum and milk at different stages of lactation显示文摘 | Cheng Z B Li D F Ge C R | 2006 | Anim Sci2006，82，1： | 1 |
| 19 | Synthesis,characterization and film morphology of dodecylpolysiloxane显示文摘 | AN Q F CHENG G W LI L S | 2006 | J Appl Polym Sci2006，101，： | 1 |
| 20 | Purification of single walled carbon nanotubes synthesized by the catalytic decomposition of hydrocarbons显示文摘 | F LI H M CHENG Y T XING P H TAN G SU | 2000 | Carbon2000，38，： | 1 |
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