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| 1 | The relationship of Imp2 and DR3 genes with susceptibility to type Ⅰ diabetes mellitus in south China Han population显示文摘AIN To study the relationship of Imp2 and DR3genes with type Ⅰ diabetes mellitus.NETHODS Imp2 genotypes and DR3 wereidentified in 68 patients with type Ⅰ diabetesmellitus(Ⅰ-DM)and 71 healthy controls.Then,Ⅰ-DM patients and controls were respectivelyallocated into DR3-positive and DR3-negativegroups.The frequencies of Imp2 and DR3 genein random subjects,and Imp2 genotypes in DR3-matched subjects were compared between Ⅰ-DMpatients and controls.At the same time,Ⅰ-DMpatients were divided into 3 groups based on theonset age of diabetics:group A≤14 years,group B 15-30 years and group C≥31 years.RESULTS The frequency of DR3 in Ⅰ-DMpatients was significantly higher than that incontrols(47% vs 21%,P<0.005),and it wassignificantly higher in group A than that in groupB+C(70% vs 36%,x^2=7.07,P<0.01).Therewas a significant difference among groups withdifferent onset age of diabetics(x^2=8.19,rp=0.33,P<0.05).In random subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(43% vs 61%,P<0.05)and Imp2.R/Hhigher(53% vs 28%,P<0.05)than that incontrols,and there was no significant differenceamong groups with different onset age ofdiabetics.In DR3-positive subjects,thefrequency of Imp2.R/R in Ⅰ-DM patients waslower(47% vs 87%,P<0.05)and Imp2-R/H higher(47% vs 13%,P<0.05)than that incontrols.In DR3-negative subjects,thefrequency of Imp2.R/H in Ⅰ-DM patients washigher than that in controls(58% vs 32%,P<0.01),but the frequency of Imp2-R/R and Imp2H/H was not significantly different betweenthese two groups.CONCLUSION DR3 gene may be one of thesusceptible genes of Ⅰ-DM,and significantlyrelated to the onset age of diabetics,and thepersons with DR3 may have an younger onsetage of diabeteS.The Imp2-R/R may be theprotective genotype of Ⅰ-DM,and Imp2-R/H thesusceptible genotype.These were not affectedby DR3 gene.Imp-2 genotypes were not relatedwith the onset age of diabetics. | Ding HL Cheng H Fu ZZ Deng QL Yan L Yan T | 2000 | World Journal of Gastroenterology2000，6，1： | 7 |
| 2 | Archaeological records of Dadiwan in the past 60 ka and the origin of millet agriculture显示文摘This paper reports the recent excavation of Unit Dadiwan06 at the Dadiwan site in Qin’an County, Gansu.A 65 ka chronological framework is established for Dadiwan06 on the basis of absolute dating (AMS 14C and OSL), stratigraphy, climate change events and archaeology.Artifact distributions reveal patterns of human behavioral variation and adaptation over the past 60 ka, from primitive hunting and gathering to advanced hunting and gathering, to primitive Neolithic agriculture, and finally to advanced Neolithic agriculture. | ZHANG DongJu CHEN FaHu BETTINGER R L BARTON L JI DuXue MORGAN C WANG Hui CHENG XiaoZhong DONG GuangHui GUILDERSON T P ZHAO Hui | 2010 | Chinese Science Bulletin2010，55，16： | 6 |
| 3 | Characteristics of gas-liquid two-phase flow in small diameter inclined tubes显示文摘 | Cheng T W Lin T L | 2001 | Chem Eng Sci2001，，56： | 2 |
| 4 | 显示文摘 | Wang X H Li L T | 2002 | Key Eng Mater2002，224，2： | 1 |
| 5 | Oxidation and defect control of CVD SiC coating on three-dimensional C/SiC composites显示文摘 | Cheng L F Xu Y D Zhang L T | 2002 | Carbon2002，40，： | 1 |
| 6 | A two-process model for study of the effect of fiber preform structure on isothermal chemical vapor infiltration of silicon carbide matrix composites 显示文摘 | HUA Y F ZHANG L T CHENG L F | 2009 | Computational Materials Science2009，46，1： | 1 |
| 7 | Synthesis and characterization of core-shell LIPN-fluorine- containing polyacrylate latex显示文摘 | Cheng X L Chen Z X Shi T S | 2007 | Colloids and Surfaces A:Physicochemical and Engineering Aspects2007，292，23： | 1 |
| 8 | Continuous extremal optimization for Lennard-Jones clusters 显示文摘 | Zhou T Bai W J Cheng L J | 2005 | Physical Review E2005，72，1： | 1 |
| 9 | Evidence of independent origin of multiple tumors from prostate cancer patients显示文摘 | Cheng L Song S Y Pretlow T G | 1997 | J Natl Cancer Inst1997，90，： | 1 |
| 10 | Frost formation on a super-hydrophobic surface under natural convection conditions 显示文摘 | Liu Z L Gou Y J WangJ T Cheng S Y | 2008 | International Journal of Heat and Mass Transfer2008，51，25： | 1 |
| 11 | Common due- window assignment and scheduling of linear time- dependent deteriorating jobs and a deteriorating maintenance activity 显示文摘 | Cheng T C E Yang S J Yang D L | 2012 | International Journal of Production Economics2012，135，1： | 1 |
| 12 | Yogurts from skim milk- whey protein concentrate blends显示文摘 | Cheng L J Augustina M A Clarke P T | 2000 | Austealian Journal of Dairy Technology2000，，55： | 1 |
| 13 | A novel time domain method to extract equivalent circuit model of patterned ground显示文摘 | Cheng C H Tsai C H Wu T L | | 0，，： | 1 |
| 14 | A thermo-responsive affinity membrane with nano-structured pores and grafted poly(N-isopropylacrylamide) surface layer for hydrophobic adsorption显示文摘 | Meng T Xie R Chen Y C Cheng C J Li P F Ju X J Chu L Y | 2010 | Journal of Membrane Science2010，349，12： | 1 |
| 15 | Adaptive-expectation based multi attribute FTS model for forecasting TAIEX显示文摘 | Liu J W Chen T L Cheng C H | 2010 | Original Research Article Computers & Mathematics with Applications2010，59，2： | 1 |
| 16 | Hydrogen effects on the post production modification of diamond-like carbon produced by pulsed laser deposition显示文摘 | Cheng C L Chia C T Chiu C C | 2001 | Diamond and Related Materials2001，10，97： | 1 |
| 17 | Preparation and properties of nano-silica modified nega- tive acrylate photoresist 显示文摘 | Lee C K Don T M Lai W C Chert C C Lin D J Cheng L P | 2008 | Thin Solid Films2008，516，23： | 1 |
| 18 | Characterization of a virion occlusion-defective Autographa californica multiple nucleopolyhedrovirus mutant lacking the p26,p10and p74genes显示文摘 | Wang L Salem T Z Campbell D J Turney C M Kumar C M Cheng X W | 2009 | J Gen Virol2009，90，7： | 1 |
| 19 | ESL/EFL instructors' classroom assessment practices: Purposes, methods, and procedures 显示文摘 | Cheng L Rogers T Hu H | 2004 | Language Testing2004，21，3： | 1 |
| 20 | Gibberellin acts through jasmonate to control the expression of MYB21,MYB24,and MYB57 to promote stamen filament growth in Arabidopsis显示文摘 | Cheng H Son S S Xiao L T | | 0，，： | 1 |
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