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| 1 | Activation of the bitter taste sensor TRPM5 prevents high saltinduced cardiovascular dysfunction显示文摘High salt intake is a known risk factor of cardiovascular diseases. Our recent study demonstrated that long-term high salt intake impairs transient receptor potential channel M5(TRPM5)-mediated aversion to high salt concentrations, consequently promoting high salt intake and hypertension;however, it remains unknown whether TRPM5 activation ameliorates cardiovascular dysfunction. Herein we found that bitter melon extract(BME) and cucurbitacin E(CuE), a major compound in BME, lowered high salt-induced hypertension. Long-term BME intake significantly enhanced the aversion to high salt concentrations by upregulating TRPM5 expression and function, eventually decreasing excessive salt consumption in mice. Moreover, dietary BME ameliorated high salt-induced cardiovascular dysfunction and angiotensin II-induced hypertension in vivo. The mechanistic evidence demonstrated that dietary BME inhibited high salt-induced RhoA/Rho kinase pathway overactivation, leading to reduced phosphorylation levels of myosin light chain kinase and myosin phosphatase targeting subunit 1. Furthermore, CuE inhibited vasoconstriction by attenuating L-type Ca^(2+) channel-induced Ca^(2+) influx in vascular smooth muscle cells. To summarize, our findings indicate that dietary BME has a beneficial role in antagonizing excessive salt consumption and thus appears promising for the prevention of high salt-induced cardiovascular dysfunction. | Hao Wu Yuanting Cui Chengkang He Peng Gao Qiang Li Hexuan Zhang Yanli Jiang Yingru Hu Xiao Wei Zongshi Lu Tianyi Ma Daoyan Liu Zhiming Zhu | 2020 | Science China(Life Sciences)2020，63，11： | 2 |
| 2 | Replanting of broadleaved trees alters internal nutrient cycles of native and exotic pines in subtropical plantations of China显示文摘Background:The replanting of broadleaved trees in pure coniferous plantations is widely implemented,as mixed plantations are generally more stable and functional.However,the effect of interspecific interactions between broadleaved and coniferous trees on internal nutrient cycles of conifers remains unclear.Methods:We selected pure coniferous plantations of a native(Pinus massoniana)and an exotic(P.elliottii)pine species and their corresponding mixed plantations with broadleaved trees(Schima superba)in subtropical China,and measured the nitrogen(N)and phosphorus(P)contents in the rhizosphere soils,fine roots,twigs,needles and needle litter of pines.We calculated the root capture,needle resorption and translocation of N and P by pines to determine the mobility of nutrients in trees.Results:Although the N and P in the rhizosphere soils increased due to the replanting of broadleaved trees,the N and P contents in the aboveground tissues of the two pine species did not increase in mixed plantations.Mixed planting had a negative effect on the N and P capture of native pine and a positive effect on that of exotic pine.The N and P resorption efficiencies increased in native pine but were unchanged in exotic pine after the replanting of S.superba.Native pine preferentially employed an aboveground nutrient resorption strategy,whereas exotic pine tended to adopt a belowground nutrient capture strategy after replanting.Translocation of N and P in trees was detected,which reflected the trade-offs between root nutrient capture and needle nutrient resorption.Conclusions:The effect of mixed planting varied between the species of native and exotic pines,and the internal nutrient cycles of both pine species might be dominated by interspecific interaction effects on nutrients rather than soil nutrients.Our study highlights the importance of selecting suitable broadleaved species for replanting in coniferous plantations. | Yong Lin Chengkang Xia Gaoyang Wu Fangchao Wang Shengnan Wang Yuanqiu Liu Fusheng Chen | 2022 | Forest Ecosystems2022，9，5： | 2 |
| 3 | Promotive effect of multi-walled carbon nanotubes on Co_3O_4 nanosheets and their application in lithium-ion battery显示文摘Co3O4/MWCNTs composites have been synthesized by a simple hydrothermal method using a surfactant(CTAB) and a precipitation agent(urea). The samples were characterized by XRD, SEM and BET methods. The electrochemical properties of the samples as anode materials for lithium batteries were studied by EIS and Galvanostatic measurements. The Co3O4/MWCNTs composites displayed higher capacity and better cycle performance in comparison with the Co3O4 nanosheets. The remarkable improvement of electrochemical performance within the hybrid composites is probably related to the addition of MWCNTs that possesses improved properties such as excellent electric conductivity and large surface area, which helps to alleviate the effect of volume change, shorten the distance of lithium ion diffusion, facilitate the transmission of electron and keep the structure stable. | Yan Liu Xiaogang Zhang Chengkang Chang Dongyun Zhang Ying Wu | 2014 | Progress in Natural Science:Materials International2014，24，3： | 1 |
| 4 | Experimental Study on the Thermal Argon Plasma Generation and Jet Length Change Characteristics at Atmospheric Pressure显示文摘 | Wenxia Pan Xian Meng Chengkang Wu Xi Chen | 2006 | Plasma Chemistry and Plasma Processing2006，，4： | 1 |
| 5 | Generation of Long, Laminar Plasma Jets at Atmospheric Pressure and Effects of Flow Turbulence显示文摘 | Wenxia Pan Wenhua Zhang Wenhong Zhang Chengkang Wu | 2001 | Plasma Chemistry and Plasma Processing2001，，1： | 1 |
| 6 | Generation of Long, Laminar Plasma Jets at Atmospheric Pressure and Effects of Flow Turbulence显示文摘 | Wenxia Pan Wenhua Zhang Wenhong Zhang Chengkang Wu | 2001 | Plasma Chemistry and Plasma Processing2001，，1： | 1 |
| 7 | Investigation of laminar plasma cladding processing显示文摘 | Ma Wei Fei Qunxing Pan Wenxia and Wu Chengkang | 2006 | Applied Surface Science2006，252，： | 1 |
| 8 | Sufficiently diffused attachment of nitrogen arc by gasdynamic action显示文摘For realizing diffused anode attachment in pure nitrogen arcs, a special arc plasma generator was designed and combined with suitable working parameters such as gas flow rate and arc current. The anode has a flow-restrictor channel of 2.8 mm diameter and downstream expansion half-angle of 8°, with the purpose of creating a dispersed nitrogen-arc column by strong gasdynamic expansion effect. Results show that,when thermal blocking condition existed in the flow restrictor and the cathode cavity pressure was higher than that in the exit chamber by at least 9 k Pa, the action due to gasdynamic expansion could be much stronger than the self-magnetic contraction effect of the arc and the nitrogen arc column could be effectively dispersed to form a sufficiently diffused attachment on the water-cooled anode surface. | Wenxia Pan Lewen Chen Xian Meng Yong Zhang Chengkang Wu | 2016 | Theoretical & Applied Mechanics Letters2016，6，6： | 1 |
| 9 | Parameter Estimation of a Spherical Top Inductively Coupled Plasma Source with Global Model显示文摘Using spatially averaged global model,we succeed in obtaining some plasma parameters for a low pressure inductively coupled plasma source of our laboratory.As far as the global balance is concerned,the models can give reasonable results of the parameters,such as the global electron temperature and the ion impacting energy,etc.It is found that the ion flow is hardly affected by the neutral gas pressure.Finally,the magnetic effects are calculated by means of the method.The magnetic field can play an important role to increase plasma density and ion current. | WU Hanming LI Ming CHEN Yunming WU Chengkang | 1995 | Chinese Physics Letters1995，12，5： | 0 |
| 10 | Improved electrochemical properties by lithium insertion into Co_3O_4 in aqueous LiOH solution显示文摘Co_3O_4 microspheres were synthesized by a simple hydrothermal treatment.The first-cycle charge-discharge tests were carried out between-0.6 and 0.6 V vs.SCE.The pristine,discharged and recharged specimens were characterized by X-ray power diffraction and scanning electron microscopy.Cyclic voltammetry(CV) curves of Co_3O_4 at various concentrations in LiOH solution were investigated.The appearance of the two pairs of redox peaks indicated that two sets of faradaic reactions were involved in the redox reactions of Co_3O_4 to LiCoO_2 and LiHCoO_2. | Yan Liu Chengkang Chang Dongyun Zhang Ying Wu | 2013 | Progress in Natural Science:Materials International2013，23，6： | 0 |
| 11 | Producing ultra-high-speed nitrogen jets by arc heating in a low-pressure chamber显示文摘Pure nitrogen gas was heated with direct current arc, at input powers from several hundred W to over 5 k W, and then injected through a nozzle into a chamber at 1 or 10 Pa pressure, with the purpose of accelerating the gas to very high speed around 7 km/s. Various structures of the arc generator and gas expansion nozzle were examined. Results show that bypass exhausting of the boundary layer before it enters the nozzle divergent section can greatly increase flow speed of the jet, thus it might be possible to use nitrogen as a working gas in high speed gas dynamic test facilities. | Wenxia Pan Xian Meng Heji Huang Chengkang Wu | 2016 | Theoretical & Applied Mechanics Letters2016，6，1： | 0 |
| 12 | Unsteadiness in non-transferred dc arc plasma generators显示文摘Non-transferred dc arc plasma generators are widely used in materials processing.They are generally considered steadily-operating devises.However,unsteady phenomena do exist in them, and may cause non-ideal effects in processes which require high controllability and reproducibility. These unsteady phenomena can cause parameter fluctuations in the arc and the plasma jet,some of which have been studied in recent years.Several types and mechanisms of these phenomena have been identified.This paper reviews t... | Chengkang Wu~(a) and Wenxia Pan Institute of Mechanics,Chinese Academy of Sciences,Beijing 100190,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，2： | 0 |
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