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| 1 | Single-Atom Catalysts for Electrochemical Hydrogen Evolution Reaction: Recent Advances and Future Perspectives显示文摘Hydrogen,a renewable and outstanding energy carrier with zero carbon dioxide emission,is regarded as the best alternative to fossil fuels.The most preferred route to large-scale production of hydrogen is by water electrolysis from the intermittent sources(e.g.,wind,solar,hydro,and tidal energy).However,the efficiency of water electrolysis is very much dependent on the activity of electrocatalysts.Thus,designing high-effective,stable,and cheap materials for hydrogen evolution reaction(HER)could have a substantial impact on renewable energy technologies.Recently,single-atom catalysts(SACs)have emerged as a new frontier in catalysis science,because SACs have maximum atom-utilization efficiency and excellent catalytic reaction activity.Various synthesis methods and analytical techniques have been adopted to prepare and characterize these SACs.In this review,we discuss recent progress on SACs synthesis,characterization methods,and their catalytic applications.Particularly,we highlight their unique electrochemical characteristics toward HER.Finally,the current key challenges in SACs for HER are pointed out and some potential directions are proposed as well. | Zonghua Pu Ibrahim Saana Amiinu Ruilin Cheng Pengyan Wang Chengtian Zhang Shichun Mu Weiyue Zhao Fengmei Su Gaixia Zhang Shijun Liao Shuhui Sun | 2020 | Nano-Micro Letters2020，12，2： | 10 |
| 2 | Biodiversity-based development and evolution:the emerging research systems in model and non-model organisms显示文摘Evolutionary developmental biology,or Evo-Devo for short,has become an established field that,broadly speaking,seeks to understand how changes in development drive major transitions and innovation in organismal evolution.It does so via integrating the principles and methods of many subdisciplines of biology.Although we have gained unprecedented knowledge from the studies on model organisms in the past decades,many fundamental and crucially essential processes remain a mystery.Considering the tremendous biodiversity of our planet,the current model organisms seem insufficient for us to understand the evolutionary and physiological processes of life and its adaptation to exterior environments.The currently increasing genomic data and the recently available gene-editing tools make it possible to extend our studies to non-model organisms.In this review,we review the recent work on the regulatory signaling of developmental and regeneration processes,environmental adaptation,and evolutionary mechanisms using both the existing model animals such as zebrafish and Drosophila,and the emerging nonstandard model organisms including amphioxus,ascidian,ciliates,single-celled phytoplankton,and marine nematode.In addition,the challenging questions and new directions in these systems are outlined as well. | Long Zhao Feng Gao Shan Gao Yujun Liang Hongan Long Zhiyi Lv Ying Su Naihao Ye Liusuo Zhang Chengtian Zhao Xiaoyu Wang Weibo Song Shicui Zhang Bo Dong | 2021 | Science China(Life Sciences)2021，64，8： | 9 |
| 3 | Zebrafish as a Model for Human Ciliopathies显示文摘Cilia, microtubule-based structures found on the surface of almost all vertebrate cells, play an array of diverse biological functions. Abnormal ciliary axonemal structure and function can result in a class of genetic disorders that are collectively termed ciliopathies. Model organisms,including Chlamydomonas reinhardtii and Caenorhabditis elegans have been widely used to study the complex genetic basis of ciliopathies.Here, we review the advantages of the zebrafish as a vertebrate model for human ciliopathies. We summarize the features of zebrafish cilia, and the major findings and contributions of the zebrafish model in recent studies of human ciliopathies. We also discuss the new genome editing approaches being efficiently used in zebrafish, and the exciting prospects of these approaches in modeling human ciliopathies. | Zhu Song Xiaoli Zhang Shuo Jia Pamela C.Yelick Chengtian Zhao | 2016 | Journal of Genetics and Genomics2016，43，3： | 6 |
| 4 | Genetic defects of pronephric cilia in zebrafish显示文摘 | Chengtian Zhao Jarema Malicki | 2007 | Mechanisms of Development2007，，7： | 1 |
| 5 | Cilia regulate meiotic recombination in zebrafish显示文摘Meiosis is essential for evolution and genetic diversity in almost all sexual eukaryotic organisms.The mechanisms of meiotic recombination,such as synapsis,have been extensively investigated.However,it is still unclear whether signals from the cytoplasm or even from outside of the cell can regulate the meiosis process.Cilia are microtubule-based structures that protrude from the cell surface and function as signaling hubs to sense extracellular signals.Here,we reported an unexpected and critical role of cilia during meiotic recombination.During gametogenesis of zebrafish,cilia were specifically present in the prophase stages of both primary spermatocytes and primary oocytes.By developing a germ cell-specific CRISPR/Cas9 system,we demonstrated that germ cell-specific depletion of ciliary genes resulted in compromised double-strand break repair,reduced crossover formation,and increased germ cell apoptosis.Our study reveals a previously undiscovered role for cilia during meiosis and suggests that extracellular signals may regulate meiotic recombination via this particular organelle. | Haibo Xie Xiaosi Wang Minjun Jin Lanqin Li Junwen Zhu Yunsi Kang Zhe Chen Yonghua Sun Chengtian Zhao | 2022 | Journal of Molecular Cell Biology2022，14，7： | 0 |
| 6 | Adrb1 and Adrb2b are the major β-adrenergic receptors regulating body axis straightening in zebrafish显示文摘Maintaining a straight body axis is essential for proper development of vertebrate embryos.During gastrulation,body axis establishment and elongation require highly orchestrated convergence-extension movements within the primordial tissues bringing them toward the midline(Myers et alM 2002;Tada and Heisenberg,2012). | Xiaoyu Wang Shuo Wang Zhaojun Meng Chengtian Zhao | 2020 | Journal of Genetics and Genomics2020，47，12： | 0 |
| 7 | Somite-specific expression of a novel fibronectin variant FN3 is negatively regulated by SHH显示文摘Fibronectins (FNs) are major extracellular proteins in blood plasma and many tissues of vertebrates, and play important roles in adhesion, migration and differentiation of cells. We have identified a novel variant (FN3) of fibronectin in zebrafish. FN3 mRNA is abundant, as detected by whole-mount in situ hybridization, in the presomitic mesoderm and the newly formed somites, but less abundant in mature somites. Ectopic expression of Sonic Hedgehog (SHH) results in a decrease of FN3 expression, whereas the expression level of FN3 increases in the flhi mutants that lack the notochord. Our results suggest that FN3 may be involved in the formation of somites, but during somite differentiation its expression needs to be downregulated by signals derived from the axial tissues. | ZHAO Chengtian ZHANG Yu SU Ying MENG Anming | 2002 | Chinese Science Bulletin2002，47，21： | 0 |
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