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| 1 | Investigation on Multiple Cylindrical Holes Casing Treatment for Transonic Axial Compressor Stability Enhancement显示文摘Casing treatment is one possible way of regaining axial compressor operating range. However, most of casing treatments extend the operating range with the cost of efficiency penalty. A new form of multiple cylindrical holes casing treatment(MHCT) with pre-swirl blowing for the NASA Rotor-37 has been designed based on profound understanding of the stall inception. Unsteady numerical simulations have been performed for Rotor-37 with and without MHCT. Parametric studies of the total extraction holes area and their axial locations show that the compressor performance deteriorates as the area ratio increases but the stall margin is extended and there is an optimum extraction holes axial location for stall margin extending. The better configuration of MHCT could extend the stall margin by 6.2% with only 0.23% peak efficiency reduction. Detailed analysis of the physical mechanism behind the stall margin improvement shows that the casing treatment could eliminate the passage blockage by suppressing breakup of tip leakage vortex and decrease the blade load in tip region, which both contribute to improve stall margin of transonic axial compressors. | YANG Chengwu ZHAO Shengfeng LU Xingen HAN Ge ZHU Junqiang | 2014 | Journal of Thermal Science2014，23，4： | 6 |
| 2 | Image decomposition using adaptive regularization and div(BMO)显示文摘In order to avoid staircasing effect and preserve small scale texture information for the classical total variation regularization, a new minimization energy functional model for image decomposition is proposed. Firstly, an adaptive regularization based on the local feature of images is introduced to substitute total variational regularization. The oscillatory component containing texture and/or noise is modeled in generalized function space div (BMO). And then, the existence and uniqueness of the minimizer for proposed model are proved. Finally, the gradient descent flow of the Euler-Lagrange equations for the new model is numerically implemented by using a finite difference method. Experiments show that the proposed model is very robust to noise, and the staircasing effect is avoided efficiently, while edges and textures are well remained. | Chengwu Lu Guoxiang Song | 2011 | Journal of Systems Engineering and Electronics2011，22，2： | 2 |
| 3 | A Multiplex PCR Assay for the Detection of Pathogenic Genes of EPEC,ETEC and EIEC显示文摘A multiplex polymerase chain reaction (PCR) was developed to detect three pathogenic genes of en-teropathogenic, enterotocigenic and enteroinvasive Escherichia coli.. In this study three different sets of oligonu-cleotide primer were simultaneously used, and in this way, specific fragments of 880, 600, 150 bp for EPEC eaeA, EIEC ipaH and ETEC ST genes were amplified, respectively. The best condition of the multiplex PCR was: after an initial heat denaturation step at 95℃ for 5 min, followed by 30 cycles of denaturation at 94℃ for 40 s, primer annealing at 51.3 ℃ for 40 s and extension at 72 ℃ for 1 min, final extension at 72 ℃ for 10 min. The detection limit of the eaeA, ipaH and ST primers was 38.7423, 3.60519, 29.9448 ng·mL-1 (4.3×104, 1.5×103, 2.6×104 CFU·mL-1), respectively. It may be a good way for the detection and identification of Diarrhea-causing E. coli. . | ZHANG Tienan LI Jichang LU Chengwu HUO Guicheng | 2006 | Journal of Northeast Agricultural University(English Edition)2006，13，1： | 2 |
| 4 | Mitochondria targeting drugs for neurodegenerative diseases——Design, mechanism and application显示文摘Neurodegenerative diseases(NDDs) such as Alzheimer’s disease(AD) and Parkinson ’s disease(PD) are a heterogeneous group of disorders characterized by progressive degeneration of neurons.NDDs threaten the lives of millions of people worldwide and regretfully remain incurable.It is well accepted that dysfunction of mitochondria underlies the pathogenesis of NDDs.Dysfunction of mitochondria results in energy depletion,oxidative stress,calcium overloading,caspases activation,which dominates the neuronal death of NDDs.Therefore,mitochondria are the preferred target for intervention of NDDs.So far various mitochondria-targeting drugs have been developed and delightfully some of them demonstrate promising outcome,though there are still some obstacles such as targeting specificity,delivery capacity hindering the drugs development.In present review,we will elaborately address 1) the strategy to design mitochondria targeting drugs,2) the rescue mechanism of respective mitochondria targeting drugs,3) how to evaluate the therapeutic effect.Hopefully this review will provide comprehensive knowledge for understanding how to develop more effective drugs for the treatment of NDDs. | Jiajia Xu Wei Du Yunhe Zhao Kahleong Lim Li Lu Chengwu Zhang Lin Li | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 2 |
| 5 | Effects of surface roughness on the aerodynamic performance of a high subsonic compressor airfoil at low Reynolds number显示文摘The aerodynamic performance of compressor airfoil is significantly affected by the surface roughness at low Reynolds number(Re).In the present study,numerical simulations have been conducted to investigate the impact of surface roughness on the profile loss of a high subsonic compressor airfoil at Re=1.5×10^(5).Four roughness locations,covering 10%,30%,50%and 100%of the suction surface from the leading edge and seven roughness magnitudes(Ra)ranging from 52 to525 lm were selected.Results showed that the surface roughness mainly determined the loss generation process by influencing the structure of the Laminar Separation Bubble(LSB)and the turbulence level near the wall.For all the roughness locations,the variation trend for the profile loss with the roughness magnitude was similar.In the transitionally rough region,the negative displacement effect of the LSB was suppressed with the increase of roughness magnitude,leading to a maximum decrease of 14.6%,16.04%,16.45%and 10.20%in the profile loss at Ra=157 lm for the four roughness locations,respectively.However,with a further increase of the roughness magnitude in the fully rough region,the stronger turbulent dissipation enhanced the growth rate of the turbulent boundary layer and increased the profile loss instead.By comparison,the leading edge roughness played a dominant role in the boundary layer development and performance variation.To take fully advantage of the surface roughness reducing profile loss at low Re,the effects of roughness on suppressing LSB and inducing strong turbulent dissipation should be balanced effectively. | Mingyang WANG Chengwu YANG Ziliang LI Shengfeng ZHAO Yanfeng ZHANG Xin’gen LU | 2021 | Chinese Journal of Aeronautics2021，34，3： | 2 |
| 6 | Effect of Non-Axisymmetric End Wall on a Highly Loaded Compressor Cascade in Multi-Conditions显示文摘As an effective method to influence end wall flow field,non-axisymmetric profiled end wall can improve the aerodynamic performance of compressor cascades.For a highly loaded low pressure compressor cascade,called V103,the study found the optimal non-axisymmetric profiled end wall decreases total pressure loss coefficient by 4.57%,5.48%and 3.04%under incidences of–3°,0°,and 3°,respectively,compared with those of the planar end wall.The optimal non-axisymmetric profiled end wall changes the structure of secondary flow in hub region,generating a corner vortex near suction surface,inhibiting the development of the passage vortex towards suction surface and reducing flow separation.When the inlet Mach numbers are 0.62 and 0.72,the total pressure loss coefficient decreases by 3.19%and 4.58%for optimal non-axisymmetric profiled end wall compared with those of the planar end wall.Though optimal non-axisymmetric profiled end wall increases total pressure loss near hub region in blade passage under different inlet Mach numbers,the peak value and region of high loss coefficient above 10%span in blade passage significantly decrease.In addition,different incidences affect the secondary flow streamlines and vortex structure near the cascade hub region,however,different inlet Mach numbers hardly change the secondary flow streamlines and vortex structure.In short,the optimal non-axisymmetric profiled end wall shows better aerodynamic performance than the planar end wall for the highly loaded compressor cascade in multi-conditions. | HUANG Song YANG Chengwu LI Ziliang HAN Ge ZHAO Shengfeng LU Xin’gen | 2021 | Journal of Thermal Science2021，30，4： | 2 |
| 7 | TV+TV2 regularization with nonconvex sparseness-inducing penalty for image restoration 显示文摘 | Lu Chengwu Huang Hua | 2014 | Mathematical Problems in Engineering2014，3，11： | 1 |
| 8 | Nonlinear approximation of image based on monoscale orthonormal ridgelets frame显示文摘A new tight frame called as monoscale orthonormal ridgelet frame (MORF) is proposed. The localization principle and the orthonormal ridgelet constructed by Donoho are applied to construct the MORF, which are used to evaluate the order of nonlinear approximation for image with edge. Because the new tight frame not only has directionality but also bears orthonormality. It overcomes redundancy of Candes's monoscale ridgelets and provides many excellent properties in practical application. Theoretical analysis and experiments demonstrate that the new frame has remarkable potential for image compression, image reconstruction, and image denoising with the simple refinement for MORF. | Lu Chengwu Song Yimei Song Guoxiang | 2007 | Journal of Systems Engineering and Electronics2007，18，4： | 1 |
| 9 | Numerical investigation of flow mechanisms of tandem impeller inside a centrifugal compressor显示文摘This study numerically investigated a single stage centrifugal compressor 'Radiver' with a wedge diffuser and several tandem-designed impellers to explore the flow phenomena within the tandem impeller and the potential to enhance compressor performance.The results demonstrate that tandem design and clocking fraction(ks)significantly affects the compressor performance.The compressor stage with tandem impellers of Series A of boundary layer growth interruption alone are observed to have a widely operating range but efficiency and total pressure ratio penalty compared with that of conventional impeller.The tandem impeller with at least the same impeller efficiency as the conventional design is considered as a critical design criteria so that further modification process based on the flow characteristic of tandem impeller is necessary.In order to restrain the inducer wake and exducer shock losses,parameters modification of blade angle and thickness distributions are necessary and the modified tandem impeller of Series B is obtained.The modified tandem impeller with 25%clocking arrangement shows an 8.45%stall margin increase and maintains the total pressure ratio and efficiency as the conventional design,which proves the potential of tandem impeller to improve compressor stage performance.It is noteworthy that the tandem impellers of Radiver have not shown obviously balanced exit flow field and the fundamental mechanism of stall margin extending of tandem impeller lies on the improved impeller/diffuser matching performance resulting from the incidence angle variation at diffuser inlet. | Ziliang LI Xin’gen LU Shengfeng ZHAO Ge HAN Chengwu YANG Yanfeng ZHANG | 2019 | Chinese Journal of Aeronautics2019，32，12： | 1 |
| 10 | Design of peptide inhibitors for furin based on the C-terminal fragment of histone H1.2显示文摘哺乳动物的职业人员蛋白质 convertase 皮毛在被发现了在多样的生理、病理学的事件起一个重要作用,例如病毒的 glycoproteins 和细菌的外毒素的激活。小、无毒、高度活跃,在禁止者的皮毛被认为是病毒和细菌引起的疾病的吸引人的药候选人。在这研究,一系列肽禁止者基于 C 终端碎片被设计并且综合嘘一 H1.2,它在皮毛上有禁止的效果在里面。用皮毛的一致底层识别顺序代替禁止者的反应地点在被发现了极大地增加禁止的活动。大多数有势力禁止者,我有 14 氨基酸残余的 4, 有 K 为皮毛的 17 nM 的 i 价值在里面。尽管大多数综合的肽是暂时的禁止者,禁止者我有九氨基酸的 5, ,保留了它的完整的力量,甚至在有皮毛在的 3 h 潜伏期以后在 37 ° C。这些禁止者可以潜在地导致发展抗病毒并且抗菌剂药混合物。 | Suming Wang Jinbo Han Yanfang Wan Wuyuan Lu Chengwu Chi | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 1 |
| 11 | Vortex dynamics and entropy generation in separated transitional flow over a compressor blade at various incidence angles显示文摘The transition process within a Laminar Separation Bubble(LSB)that formed on a compressor blade surface was investigated using Large Eddy Simulations(LESs)at a Reynolds number of 1.5×10;and incidence angles of 0°,+3°,and+5°.The vortex dynamics in the separated shear layers were compared at various incidence angles and its effects on the loss generation were clarified through entropy analysis.Results showed that transition onset,which was accurately identified by the Linear Stability Theory(LST),was significantly promoted at the increased incidence angle.As such,the development of LSB was suppressed and the relative role of viscous instability played in the transition process was weakened.At the incidence angle of 0°,two-dimensional spanwise vortices detached from the blade surface and roiled up periodically,which were further stretched and eventually evolved into large-scale hairpin vortices.As time passed,the fully developed hairpin vortices broke down into small-scale eddies.Meanwhile,the flow near the wall reversely ejected into the outer separated shear layers and a sweeping process happened subsequently,forcing the separated shear layers to reattach and accelerating the generation of turbulent fluctuations.By comparison,the strength of vortex rolling-up was weakened at higher incidence angles,and the vortex pairing and breakdown of large-scale vortices were less pronounced.Therefore,the level of turbulent fluctuations that generated in the separated shear layers was reduced.Detailed entropy analysis showed that the turbulent dissipation effect related to the Reynolds shear stresses determined the largest amount of positive entropy generation,which declined to a lower level as the incidence angle increased from 0°to+5°.Correspondingly,the profile loss was reduced by 50.4%. | Mingyang WANG Ziliang LI Ge HAN Chengwu YANG Shengfeng ZHAO Yanfeng ZHANG Xin’gen LU | 2022 | Chinese Journal of Aeronautics2022，35，3： | 1 |
| 12 | Inducer/Exducer Matching Characteristics inside Tandem Impellers of a Highly Loaded Centrifugal Compressor显示文摘A centrifugal compressor usually operates with low isentropic efficiency and a terrible stable operating range, resulting from the complex impeller flow structure companied with the intense interaction among the impeller and the diffuser downstream. In many studies, the potential of centrifugal compressor tandem-impeller configurations for improving the compressor has been demonstrated. Whereas, compared with the convincing results on the tandem-designed axial compressors, the results on tandem impellers are limited and contradictory. Very little insight has been provided into the flow mechanisms inside tandem impellers, which is considered to be the primary reason for the confusion in tandem impeller design and application. Tandem impellers are expected to exhibit a totally different behavior due to the intense aerodynamic interaction between the inducer and the exducer, which substantially contributes to the flow structure and the compressor performance change. In the present study, a numerical study of a highly-loaded centrifugal compressor with various tandem designs was conducted to explore the inducer/exducer matching characteristics and the underlying flow mechanism inside tandem impellers. Two tandem impeller design parameters, namely, the inducer/exducer clocking fraction and the axial gap(overlap), were considered in the tandem impeller design process. The tandem impeller was also compared to the existing conventional impeller which the tandem impeller was redesigned for. The results demonstrated that the tandem-designed impeller can improve the centrifugal compressor stage performance and intense inducer/exducer interaction can be observed with changes in the clocking fraction and the axial gap(overlap). The tandem impeller performance is sensitive to changes in axial gap(overlap) when the suction side of the exducer blade is circumferentially close to the inducer blade. The fundamental reason for the performance variation in the inducer and the exducer lies in the inducer pressure change in the blade trailing edge that is determined by the Kutta condition. Additionally, the correlation between the tandem impeller slip effect and the discharge flow quality should be emphasized in the inducer/exducer gap jet analysis, in which the jet injection angle and the Coanda effect of the exducer suction surface critically affect the discharge flow characteristics. | LI Ziliang ZHAO Shengfeng LU Xin’gen HAN Ge YANG Chengwu ZHU Junqiang | 2020 | Journal of Thermal Science2020，29，4： | 0 |
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