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您的检索式：作者名="Chenming Qu"
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| 1 | Deficiency of Mouse CD4^+CD25^+Foxp3^+ Regulatory T Cells in Xenogeneic Pig Thymus-Grafted Nude Mice Suffering from Autoimmune Diseases显示文摘Xenogeneic thymus transplantation can efficiently induce specific immune tolerance to donor antigens in athymic recipients. However, many nude mice suffer from autoimmune diseases (AID) for over 10 weeks after xenogeneic thymus transplantation. CD4+CD25+Foxp3+ regulatory T (Treg) cells were recently determined to play a pivotal role in keeping immune tolerance in humans and mice. Thus, we investigated this subpopulation of Treg cells in the periphery of pig thymus-grafted nude mice suffering from AID. Our results showed that the expression of Foxp3, CTLA-4 and GITR on mouse CD4+CD25+ T cells and the ratio of CD4+CD25+Foxp3+ Treg cells to CD4+ T cells were significantly decreased in the periphery of pig thymus-grafted nude mice suffering from AID, compared with healthy pig or mouse thymus-grafted nude mice. Furthermore, mouse CD4+CD25+ T cells in pig thymus-grafted nude mice suffering from AID showed more severe deficiency in immunosuppressive function compared with the counterpart in xenogeneic pig or syngeneic thymus-grafted nude mice without AID. Thus, the decreased frequency, altered phenotype and functional deficiency of mouse CD4+CD25+ Treg cells in pig thymus-grafted nude mice may contribute to the development of AID in this model. | Baojun Zhang Chenming Sun Yanyan Qu Aijun Zhang Jun Liu Lianjun Zhang Zeqing Niu Yong Zhao | 2008 | Cellular & Molecular Immunology2008，5，5： | 6 |
| 2 | Research progress on immunotherapy targeting the tumor immune microenvironment for cholangiocarcinoma显示文摘Cholangiocarcinoma(CCA)is the second most common hepatobiliary cancer,and its incidence has increased significantly in recent years.CCA has poor prognosis owing to the limited diagnosis and treatment options.The tumor immune microenvironment(TIME),which comprises immune cells,cytokines,and chemokines,plays a significant role in cancer progression,the evasion of immune surveillance,and therapeutic responses.Immunotherapeutic strategies targeting the TIME offer the potential for the recognition and eradication of CCA.This review discusses the cellular and molecular components of the TIME in CCA and immunotherapeutic strategies targeting it. | Tianyin Ma Zhang Chen Yibo Chai Xiangdong Gongye Peng Xia Chenming Qu Ming Tian Yufeng Yuan | 2023 | Oncology and Translational Medicine2023，9，2： | 0 |
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