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| 1 | Reversing the imbalance in bone homeostasis via sustained release of SIRT-1 agonist to promote bone healing under osteoporotic condition显示文摘The imbalance of bone homeostasis is the root cause of osteoporosis.However current therapeutic approaches mainly focus on either anabolic or catabolic pathways,which often fail to turn the imbalanced bone metabolism around.Herein we reported that a SIRT-1 agonist mediated molecular therapeutic strategy to reverse the imbalance in bone homeostasis by simultaneously regulating osteogenesis and osteoclastogenesis via locally sustained release of SRT2104 from mineral coated acellular matrix microparticles.Immobilization of SRT2104 on mineral coating(MAM/SRT)harnessing their electrostatic interactions resulted in sustained release of SIRT-1 agonist for over 30 days.MAM/SRT not only enhanced osteogenic differentiation and mineralization,but also attenuated the formation and function of excessive osteoclasts via integrating multiple vital upstream signals(β-catenin,FoxOs,Runx2,NFATc1,etc.)in vitro.Osteoporosis animal model also validated that it accelerated osteoporotic bone healing and improved osseointegration of the surrounding bone.Overall,our work proposes a promising strategy to treat osteoporotic bone defects by reversing the imbalance in bone homeostasis using designated small molecule drug delivery systems. | Wei Zhang Xingzhi Zhou Weiduo Hou Erman Chen Chenyi Ye Mo Chen Qian Lu Xiaohua Yu Weixu Li | 2023 | Bioactive Materials2023，，1： | 2 |
| 2 | Multifunctional succinate additive for flexible perovskite solar cells with more than 23%power-conversion efficiency显示文摘Flexible perovskite solar cells(FPSCs)have emerged as power sources in versatile applications owing to their high-efficiency characteristics,excellent flexibility,and relatively lowcost.Nevertheless,undesired strain in perovskite films greatly impacts the power-conversion efficiency(PCE)and stability of PSCs,particularly in FPSCs.Herein,a novel multifunctional organic salt,methylammonium succinate,which can alleviate strain and reinforce grain boundaries,was incorporated into the perovskite film,leading to relaxed microstrain and a lower defect concentration.As a result,a PCE of 25.4%for rigid PSCs and a record PCE of 23.6%(certified 22.5%)for FPSCs have been achieved.In addition,the corresponding FPSCs exhibited excellent bending durability,maintaining85%of their initial efficiency after bending at a 6 mm radius for 10000 cycles. | Minghao Li Junjie Zhou Liguo Tan Hang Li Yue Liu Chaofan Jiang Yiran Ye Liming Ding Wolfgang Tress Chenyi Yi | 2022 | The Innovation2022，3，6： | 2 |
| 3 | Depletion ofPHF14, a novel histone-binding protein gene, causes neonatal lethality in mice due to respiratory failure显示文摘植物 homeodomain (哲学博士) 手指在许多染色质绑定蛋白质被识别,并且作为 recognizesspecific epigenetic 在 histone 尾巴上标记的一个阅读器工作,衔接到染色质的抄写因素和他们的联系建筑群, andregulating 基因表示。哲学博士包含手指的蛋白质执行许多生物功能并且包括癌症涉及许多 humandiseases。PHF14 用多重哲学博士手指为蛋白质被预言到代码。然而,它的功能是未辩别出的。这 studyis 到的目的描绘 PHF14 并且由包括老鼠 gene-targetingknockout,并且分子的克隆和描述采用多重途径调查它的生物意义。在人的房间行的 PHF14 的三个抄本被反向的 transcriptase 聚合酶链反应识别。PHF14 (PHF14 和 PHF14 ) 的二 isoforms 在这研究被克隆。PHF14 无所不在地在老鼠纸巾和人的房间行被表示,这被发现。PHF14, PHF14 的主要 isoform,在原子核是局部性的并且也在房间分割期间跳了到染色质。有趣地, co-immunoprecipitation 结果建议 PHF14 经由它的哲学博士手指跳了到 histones。惊人地,在老鼠的 PHF14 的指向基因的大美人由于呼吸失败导致了新生的致命性。病理学的分析在多重机关揭示了 tissueand 房间结构的严重混乱,特别地在肺。这些结果显示 PHF14 可能是 epigeneticregulator 并且在鼠标在多重机关的开发起一个重要作用。 | Qin Huang Lin Zhang Yiguo Wang Chenyi Zhang Shuhua Zhou Guang Yang Zhongqiang Li Xiang Gao Zhengjun Chen Zhe Zhang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，8： | 1 |
| 4 | A high-efficiency low-voltage class-EPA for IoT applications in sub-1 GHz frequency range显示文摘We present and propose a complete and iterative integrated-circuit and electro-magnetic(EM) co-design methodology and procedure for a low-voltage sub-1 GHz class-E PA.The presented class-E PA consists of the onchip power transistor,the on-chip gate driving circuits,the off-chip tunable LC load network and the off-chip LC ladder low pass filter.The design methodology includes an explicit design equation based circuit components values' analysis and numerical derivation,output power targeted transistor size and low pass filter design,and power efficiency oriented design optimization.The proposed design procedure includes the power efficiency oriented LC network tuning,the detailed circuit/EM co-simulation plan on integrated circuit level,package level and PCB level to ensure an accurate simulation to measurement match and first pass design success.The proposed PA is targeted to achieve more than 15 dBm output power delivery and 40% power efficiency at 433 MHz frequency band with 1.5 V low voltage supply.The LC load network is designed to be off-chip for the purpose of easy tuning and optimization.The same circuit can be extended to all sub-1 GHz applications with the same tuning and optimization on the load network at different frequencies.The amplifier is implemented in 0.13 μm CMOS technology with a core area occupation of 400 μm by 300 μm.Measurement results showed that it provided power delivery of 16.42 dBm at antenna with efficiency of 40.6%.A harmonics suppression of 44 dBc is achieved,making it suitable for massive deployment of IoT devices. | Chenyi Zhou Zhenghao Lu Jiangmin Gu Xiaopeng Yu | 2017 | Journal of Semiconductors2017，38，10： | 0 |
| 5 | 机械力诱导MHC-Ⅰ构象变化增强TCR抗原识别及T细胞活化显示文摘CD8+T细胞主要通过T细胞表面受体(T cell recep tor,TCR)识别并与Ⅰ型主要组织性复合物提呈的抗原(pMHC-Ⅰ)相互作用[1]。TCR对刺激型抗原的识别在CD8+T细胞毒性和适应性免疫中发挥着关键作用。许多证据表明机械力可以延长TCR与刺激性pMHC作用的键合时间(bond lifetime)形成抗原特异性逆锁键(catch bond)[2],并且这种逆锁键对抗原识别非常重要。然而,机械力调控TCR抗原识别的具体结构机制仍不清楚。通过分子动力学模拟、单分子生物膜力学探针、磁镊、T细胞活化实验和动物模型对此问题展开了系统的研究[4]。发现作用在TCR-pMHC-Ⅰ复合体上的拉力可以作用在TCR-pMHC-Ⅰ复合体上的拉力可以打破MHC-I分子内部α1-α2和β2结构域间的相互作用,导致α1-α2结构域旋转并发生构象变化。力诱导的MHC-I构象变化可以进一步别构地调节TCR与刺激性抗原肽及α1-α2结构域的构象及相互作用,诱导产生新的氢键,增强TCR-pMHC-Ⅰ之间的键合时间,但并不能增强TCR与抑制性pMHC-Ⅰ之间的作用。当用点突变阻断这些新形成的氢键,或者α1-α2和β2结构域被二硫键锁住时,最佳力诱导的TCR-pMHC-Ⅰ作用的键合时间明显缩短并且T细胞的活化受到抑制。另外,在人TCR和HLA-A2相互作用中发现了类似机制,并且与肿瘤相关的HLA-A2点突变[3]可以通过限制HLA-A2α1--α2和β2结构域之间的构象打开减弱TCR对肿瘤抗原的识别及T细胞的功能。研究结果表明,机械力诱导的MHC-I构象变化对TCR抗原识别和T细胞活化非常重要,进一步地阐明了机械力调控TCR抗原识别机制,为临床肿瘤的免疫治疗和药物设计提供了新思路和新靶点。 | Peng Wu Tongtong Zhang Baoyu Liu Panyu Fei Lei Cui Rui Qin Huaying Zhu Danmei Yao Ryan Martinez Wei Hu Chenyi An Yong Zhang Junwei Liu Weiwei Yin Jie Sun Chun Zhou Xun Zeng Jianan Wang Brian Evavold Cheng Zhu Jizhong Lou Wei Chen | 2019 | 医用生物力学2019，34，A01： | 0 |
| 6 | Double Layer Composite Electrode Strategy for Efficient Perovskite Solar Cells with Excellent Reverse-Bias Stability显示文摘Perovskite solar cells(PSCs)have become the represent-atives of next generation of photovoltaics;nevertheless,their stability is insufficient for large scale deployment,particularly the reverse bias stability.Here,we propose a transparent conducting oxide(TCO)and low-cost metal composite electrode to improve the stability of PSCs without sacrificing the efficiency.The TCO can block ion migrations and chemical reactions between the metal and perovskite,while the metal greatly enhances the conductivity of the composite electrode.As a result,composite electrode-PSCs achieved a power conversion efficiency(PCE)of 23.7%(certified 23.2%)and exhibited excellent stability,maintaining 95%of the initial PCE when applying a reverse bias of 4.0 V for 60 s and over 92%of the initial PCE after 1000 h continuous light soaking.This composite electrode strategy can be extended to different combinations of TCOs and metals.It opens a new avenue for improving the stability of PSCs. | Chaofan Jiang Junjie Zhou Hang Li Liguo Tan Minghao Li Wolfgang Tress Liming Ding Michael Grätzel Chenyi Yi | 2023 | Nano-Micro Letters2023，15，1： | 0 |
| 7 | Brominated PEAI as Multi-Functional Passivator for High-Efficiency Perovskite Solar Cell显示文摘The interfaces of perovskite solar cells(PSCs)are well known to be rich in deep-level carrier traps,which serve as non-radiative recombination centers and limit the open-circuit voltage(Voc)and power conversion efficiency(PCE)of PSCs.Defect chemistry and surface passivators have been researched extensively and mainly focused on the neutralization of uncoordinated lead or anion defects.Herein,a novel brominated passivator 2-bromophenethylammonium iodide(2-Br-PEAI)is introduced for a multi-functional passivation effect at the perovskite interface.The brominated species readily form 2D perovskite on top of the 3D perovskite and multi-interact with the 3D perovskite surface.Apart from the halide vacancy filling and anion bonding ability,the Br atoms on the benzene ring can interact with the FA cations via strong hydrogen bonding N-H…Br and interact with the[PbI_(6)]^(4−)inorganic framework.The interface defects in the PSCs are well passivated,minimizing non-radiative recombination and enhancing device performance.As a result,a champion PCE of 24.22%was achieved with high V_(oc)and fill factor.In addition,modified devices also showed enhanced operational stability(retention of>95%initial PCE after 400 h)and humidity resistance(>90%initial PCE maintained after 1500 h under~50%RH). | Minghao Li Junjie Zhou Liguo Tan Yue Liu Siyang Wang Chaofan Jiang Hang Li Xing Zhao Xingyu Gao Wolfgang Tress Liming Ding Chenyi Yi | 2023 | Energy & Environmental Materials2023，6，3： | 0 |
| 8 | Chaos Raman distributed optical fiber sensing显示文摘The physics principle of pulse flight positioning is the main theoretical bottleneck that restricts the spatial resolution of the existing Raman distributed optical fiber sensing scheme.Owing to the pulse width of tens of nanoseconds,the spatial resolution of the existing Raman distributed optical fiber sensing scheme with kilometer-level sensing distance is limited to the meter level,which seriously restricts the development of the optical time-domain reflection system.In this paper,a chaos laser is proposed in the context of the physical principle of the Raman scattering effect,and a novel theory of chaos Raman distributed optical fiber sensing scheme is presented.The scheme reveals the characteristics of chaos Raman scattering light excited by a chaotic signal on the sensing fiber.Further,the chaos time-domain compression demodulation mechanism between the temperature variation information and chaos correlation peak is demonstrated.Then,the position of the temperature variation signal is precisely located using the delay time of the chaos correlation peak combined with the chaos pulse flight time.Based on this novel optical sensing mechanism,an experiment with 10 cm spatial resolution and 1.4 km sensing distance was conducted,and the spatial resolution was found to be independent of the sensing distance.Within the limit of the existing spatial resolution theory,the spatial resolution of the proposed scheme is 50 times higher than that of the traditional scheme.The scheme also provides a new research direction for optical chaos and optical fiber sensing. | Chenyi Wang Jian Li Xinxin Zhou Zijia Cheng Lijun Qiao Xiaohui Xue Mingjiang Zhang | 2023 | Light(Science & Applications)2023，12，10： | 0 |
| 9 | Tumor Microenvironment-Specific Chemical Internalization for Enhanced Gene Therapy of Metastatic Breast Cancer显示文摘Benefiting from treating diseases at the genetic level,gene therapy has been considered a new revolution in the biomedical field.However,the extracellular and intracellular barriers during gene transport such as enzymatic degradation and endo-/lysosomal sequestration significantly compromise the therapeutic efficacy.Though photochemical internalization(PCI)has emerged as a promising approach for causing endo-/lysosomal leakage with translocation of the internalized molecules into the cytosol,its effect is still unsatisfactory due to the insufficient light penetration depth.Here,we develop tumor microenvironment-specific enhanced gene delivery by means of ROS generated from the in situ cascaded catalytic reactions in tumors involving GOx-mediated redox reaction and Mn2+-mediated Fenton-like reaction.The efficient enzymatic protection and successful endo-/lysosomal escape of cargo gene complexes have been demonstrated.Moreover,anti-Twist siRNA-loaded G@MMSNs-P exhibit tumor-specific biodegradation,excellent T1-weighted MR imaging,and significant inhibitory effects against breast cancer growth and pulmonary metastasis. | Yun Zhou Mian Yu Changjun Tie Yang Deng Junqing Wang Yunfei Yi Fan Zhang Chenyi Huang Hairong Zheng Lin Mei Meiying Wu | 2021 | Research2021，，1： | 0 |
| 10 | Efficacy of Heshouwu(Radix Polygoni Multiflori)on gut mircobiota in mice with autoimmune encephalomyelitis显示文摘OBJECTIVE:To learn the mechanisms between gut microbiome and the autoimmunity benefits on Traditional Chinese Medicine(TCM)in central nervous system(CNS),we investigated the neuro-protection effects and gut mircobiota changes of Heshouwu(Radix Polygoni Multiflori)on experimental autoimmune encephalomyelitis(EAE),an animal model of multiple sclerosis(MS).METHODS:Mice were randomly divided into four groups:EAE mice(control phosphate-buffered saline group),50 mg·kg^(-1)·d^(-1)Heshouwu(Radix Polygoni Multiflori)-treated EAE mice,100 mg·kg^(-1)·d^(-1)Heshouwu(Radix Polygoni Multiflori)-treated EAE mice,and 200 mg·kg^(-1)·d^(-1)Heshouwu(Radix Polygoni Multiflori)-treated EAE mice.The spinal cords were stained with hematoxylin and eosin(HE)and luxol fast blue for evaluating inflammatory infiltration and demyelination.The percentages of granulocyte macrophage-colony stimulating factor(GM-CSF)+CD4+,interleukin 17(IL-17)+CD4+,Foxp3 CD4+,and interferon-γ(IFN-γ)+CD4+T cells in the inguinal lymph nodes(LNs)and brain were determined by flow cytometry analysis.16S rRNA gene sequencing was employed to analyze the changes in gut microbiota.RESULTS:We found that Heshouwu(Radix Polygoni Multiflori)alleviated the disease severity and neuropathology of EAE as evaluated by clinical and histopathologyical scores.Heshouwu(Radix Polygoni Multiflori)increased the diversity and abundance of the gut microbiota,and decreased Firmicutes/Bacteroidetes ratio(F/B ratio).Heshouwu(Radix Polygoni Multiflori)also decreased the concentrations of IL-10,and IL-21 and increase the levels of GM-CSF,IL-17A,IL-17F and IL-22 in serum of EAE mice.Moreover,Heshouwu(Radix Polygoni Multiflori)modulated the T cell responses by inhibiting Th17 cells and restoring Treg cells in the small intestine lymphoid tissues and inguinal lymph nodes.Microbiota-depleted mice receiving Heshouwu(Radix Polygoni Multiflori)-treated fecal microbiota transplantation had lower disease severity,neuropathology scores and alleviation of Th17/Treg imbalance compared to ad libitum group.CONCLUSIONS:Our findings suggested that the vital neuro-protection role of Heshouwu(Radix Polygoni Multiflori)(TCM)in immunomodulation effects partly by regulations of gut microbiome. | ZHOU Jun WANG Junhua LI Xiaobing WAN Chenyi LI Fangjun LüYanni CHEN Hao SUN Meiying | 2023 | Journal of Traditional Chinese Medicine2023，43，4： | 0 |
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